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Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacologic Strategy toward Prevention of Metastases

  • Simon Karpatkin
  • Edward Pearlstein
Chapter
Part of the Developments in Oncology book series (DION, volume 22)

Abstract

Recent reports from several laboratories have emphasized the role of platelets in the development of certain tumor metastases (for review see 1). Platelets interact with certain tumor emboli, and in so doing, appear to enhance their survival in vivo. Both platelets as well as tumor cells adhere to subendothelial basement membrane. Platelets secrete permeability factors (2, 3) as well as tumor cell growth factors (4–7), which theoretically should assist in tumor cell penetration of the vessel wall and development of extravascular secondary tumor colonies.

Keywords

Platelet Aggregation Platelet Rich Plasma Aggregate Platelet LoVo Cell CT26 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Simon Karpatkin
  • Edward Pearlstein

There are no affiliations available

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