Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacologic Strategy toward Prevention of Metastases

  • Simon Karpatkin
  • Edward Pearlstein
Part of the Developments in Oncology book series (DION, volume 22)


Recent reports from several laboratories have emphasized the role of platelets in the development of certain tumor metastases (for review see 1). Platelets interact with certain tumor emboli, and in so doing, appear to enhance their survival in vivo. Both platelets as well as tumor cells adhere to subendothelial basement membrane. Platelets secrete permeability factors (2, 3) as well as tumor cell growth factors (4–7), which theoretically should assist in tumor cell penetration of the vessel wall and development of extravascular secondary tumor colonies.


Platelet Aggregation Platelet Rich Plasma Aggregate Platelet LoVo Cell CT26 Cell 
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  1. 1.
    Karpatkin S and Pearlstein E. Ann. Intern. Med. 95: 636–641, 1981.PubMedGoogle Scholar
  2. 2.
    Nachman RL, Weksler B and Ferris B. J. Clin. Invest. 51: 549–556, 1972.PubMedCrossRefGoogle Scholar
  3. 3.
    Packham MA, Nishizawa EE and Mustard JF. Biochem. Pharmacol. 17 (Suppl): 171–184, 1968.CrossRefGoogle Scholar
  4. 4.
    Cowan DH and Graham J. In: Interaction of Platelets and Tumor Cells (Ed. Jamieson GA), Alan R. Liss, New York, pp. 249–268, 1982.Google Scholar
  5. 5.
    Eastment CT and Sirbasku DA. J. Cell. Physiol. 97: 17–28, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Hara Y, Steiner M and Baldini MG. Cancer Res. 40: 1212–1216, 1980.PubMedGoogle Scholar
  7. 7.
    Kepner N and Lipton A. Cancer Res. 41: 430–432, 1981.PubMedGoogle Scholar
  8. 8.
    Pearlstein E, Cooper LB and Karpatkin S. J. Lab. Clin. Med. 93: 332–344, 1979.PubMedGoogle Scholar
  9. 9.
    Karpatkin S, Smerling A and Pearlstein E. J. Lab. Clin. Med. 96: 994–1001, 1980.PubMedGoogle Scholar
  10. 10.
    Pearlstein E, Salk PL, Yogeeswaran G and Karpatkin S. Proc. Natl. Acad. Sci. USA 77: 4336–4339, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Pearlstein E, Ambrogio C, Gasic G and Karpatkin S. Cancer Res. 41: 4535–4539, 1981.PubMedGoogle Scholar
  12. 12.
    Lerner WA, Pearlstein E, Ambrogio C and Karpatkin S. Int. J. Cancer 31: 463–469, 1983.Google Scholar
  13. 13.
    Brattain MS, Strobel-Stevens J, Fine D, Webb M and Sarrif AM. Cancer Res. 40: 2142–2146, 1980.PubMedGoogle Scholar
  14. 14.
    Griswold DP and Corbett TH. Cancer (Philadelphia) 36: 2441–2444, 1975.CrossRefGoogle Scholar
  15. 15.
    Sato N, Michaelides MC and Wallack MK. Cancer Res. 41: 2267–2272, 1981.PubMedGoogle Scholar
  16. 16.
    Tan MH, Holyoke ED and Goldrosen MH. J. Natl. Cancer Inst. 56: 871–874, 1976.PubMedGoogle Scholar
  17. 17.
    Salk P and Yogeeswaran G. Fed. Proc. Fed. Am. Soc. Exp. Biol. (Abstract) 37: 1760.Google Scholar
  18. 18.
    Yogeeswaran G, Sebastian H and Stein BS. Int. J. Cancer 24: 193–202, 1979.PubMedCrossRefGoogle Scholar
  19. 19.
    Tangen D and Berman HJ. Adv. Exp. Med. Biol. 34: 235–243, 1972.PubMedGoogle Scholar
  20. 20.
    Nesheim ME, Prendergast FG and Mann KG. Biochem. 18: 996–1003, 1979.CrossRefGoogle Scholar
  21. 21.
    Nagano W, Okamoto S, Ikezawa K, Minura K, Matruoka A, Hujikata A and Tamao Y. Thromb. Haemostasis 46: 0128A, 1981.Google Scholar
  22. 22.
    Tamao Y, Hara H, Kikumota R and Okamoto S. Thromb. Haemostasis 46: 0130A, 1981.Google Scholar
  23. 23.
    Gasic G, Koch PAG, Hsu B, Gasic TB and Niewiarowski S. Z. Krebsforsch 86: 263–277, 1976.CrossRefGoogle Scholar
  24. 24.
    Weiss HJ. N. Engl. J. Med. 293: 531–541, 1975.PubMedCrossRefGoogle Scholar
  25. 25.
    Davey MG and Luscher EF. Thromb. Math. Haemorrh. 20 (Suppl.): 283, 1966.Google Scholar
  26. 26.
    Ossowski L, Unkeless JC, Tobia A, Quigley JP, Rifkin DB and Reich E. J. Exp. Med. 137: 112–126, 1973.PubMedCrossRefGoogle Scholar
  27. 27.
    Goldberg AR. Cell 2: 95–102, 1974.PubMedCrossRefGoogle Scholar
  28. 28.
    Hynes RO and Pearlstein E. J. Suprairol. Struct. 4: 1–14, 1976.CrossRefGoogle Scholar
  29. 29.
    Gasic GJ and Gasic TB. Proc. Natl. Acad. Sci. USA 48: 1172–1177, 1962.PubMedCrossRefGoogle Scholar
  30. 30.
    Gasic GJ, Gasic TB, Galanti N, Johnson T and Murphy S. Int. J. Cancer 11: 704–718, 1973.PubMedCrossRefGoogle Scholar
  31. 31.
    Kolenich JJ, Mansour EG and Flynn A. Lancet (Letter) 2: 714, 1972.CrossRefGoogle Scholar
  32. 32.
    Wood S Jr. and Hilgard P. Lancet (Letter) 2: 1416–1417, 1972.CrossRefGoogle Scholar
  33. 33.
    Hilgard P, Heller H and Schmidt CG. Z. Krebsforsch 86: 243–250, 1976.CrossRefGoogle Scholar
  34. 34.
    Gordon S, Witul M, Cohen H, Sciandra J, Williams P, Gastpar H, Murphy GP and Ambrus JL. J. Med. 10: 435–441, 1979.PubMedGoogle Scholar
  35. 35.
    Honn KV, Cicone B and Skoff A. Science 212: 1270–1272, 1981.PubMedCrossRefGoogle Scholar
  36. 36.
    Fitzpatrick FA and Stringfellow DA. Proc. Natl. Acad. Sci. USA 76: 1765–1769, 1979.PubMedCrossRefGoogle Scholar
  37. 37.
    Stringfellow DA and Fitzpatrick FA. Nature (London) 282: 76–78, 1979.CrossRefGoogle Scholar

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© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Simon Karpatkin
  • Edward Pearlstein

There are no affiliations available

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