Transmural Flow During Physiological Vasodilation
It is well established that coronary blood flow is influenced by 1) metabolic activity of the myocardium and 2) by mechanical forces generated by contracting cardiac muscle. Of course, these factors are interrelated. Usually they are positively correlated with increases in cardiac function associated with increases in myocardial metabolism and with increases in coronary blood flow (1,2,3). On the other hand, cardiac function directly influences coronary blood flow, and this direct effect may oppose that caused indirectly by associated changes in myocardial metabolism. Thus, it is appropriate for this symposium to address the question of metabolic versus mechanical control of the coronary circulation.
KeywordsDioxide Ischemia Attenuation Lactate Adenosine
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