Transmural Flow During Physiological Vasodilation
It is well established that coronary blood flow is influenced by 1) metabolic activity of the myocardium and 2) by mechanical forces generated by contracting cardiac muscle. Of course, these factors are interrelated. Usually they are positively correlated with increases in cardiac function associated with increases in myocardial metabolism and with increases in coronary blood flow (1,2,3). On the other hand, cardiac function directly influences coronary blood flow, and this direct effect may oppose that caused indirectly by associated changes in myocardial metabolism. Thus, it is appropriate for this symposium to address the question of metabolic versus mechanical control of the coronary circulation.
KeywordsLeft Anterior Descend Myocardial Blood Flow Coronary Flow Coronary Blood Flow Regional Myocardial Blood Flow
Unable to display preview. Download preview PDF.
- 4.Gregg DE, Sabiston DC: Current research and problems of the coronary circu¬lation. Circulation (13): 916–927, 1956.Google Scholar
- 6.Moir TW, DeBra DW: Effect of left ventricular hypertension, ischemia and vasoactive drugs on the myocardial distribution of coronary flow. Circ. Res (21): 65–74, 1967.Google Scholar
- 8.Crystal GO, Downey HF, Bashour FA: Small vessel and total coronary blood volume during intracoronary adenosine. Am J Physiol 241 (Heart Circ Physiol 10): H194 - H201, 1981.Google Scholar
- 9.Warltier DC, Gross GJ, Brooks HL: Pharmacologic- vs ischemia-induced coronary artery vasodilation. Am J Physiol (Heart Circ Physiol 240 ): H767 - H774, 1981.Google Scholar
- 11.Olsson RA : Myocardial reactive hyperemia. Circ Res (37): 263–270, 1970.Google Scholar
- 13.Murthy VS, Lee PL: Effect of left ventricular relaxation on diastolic coronary blood flow during maximal vasodilation of reactive hyperemia. Fed Proc (35): 349, 1976.Google Scholar
- 19.Downey HF, Crystal GJ, Williams AG, Bashour FA: Transmural uniformity of coronary blood flow in hypoxic, non-ischemic left ventricular myocardium. Physiologist (26): A43, 1983.Google Scholar
- 22.Murray PA, Vatner SF: Alpha-adrenergic attenuation of the coronary vascular responses to severe exercise in the conscious dog. Circ Res (45): 654–660, 1979.Google Scholar
- 24.Barnard RJ, Duncan HW, Livesay JJ, Buckberg GD: Coronary vasodilator reserve and flow distribution during near-maximal exercise in dogs.J Appl Physiol: Respirat Environ Exercise Physiol (43): 988–992, 1977.Google Scholar