Transmural Flow During Physiological Vasodilation

  • H. Fred Downey
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 42)


It is well established that coronary blood flow is influenced by 1) metabolic activity of the myocardium and 2) by mechanical forces generated by contracting cardiac muscle. Of course, these factors are interrelated. Usually they are positively correlated with increases in cardiac function associated with increases in myocardial metabolism and with increases in coronary blood flow (1,2,3). On the other hand, cardiac function directly influences coronary blood flow, and this direct effect may oppose that caused indirectly by associated changes in myocardial metabolism. Thus, it is appropriate for this symposium to address the question of metabolic versus mechanical control of the coronary circulation.


Left Anterior Descend Myocardial Blood Flow Coronary Flow Coronary Blood Flow Regional Myocardial Blood Flow 
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© Martinus Nijhoff Publishing, Boston 1984

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  • H. Fred Downey

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