Current Approaches to the Management of Hemolytic Uremic Syndrome

  • Bernard S. Kaplan
  • Peter D. Thomson
Part of the Developments in Nephrology book series (DINE, volume 7)


As exemplified by our own experience (1,2), there has been a considerable improvement in the results of treatment of patients with hemolytic uremic syndrome (HUS). In Johannesburg in 1970, we studied 67 patients retrospectively and found an overall mortality rate of 34% (1). Further analysis revealed that 71% of severely affected cases died; none of the cases judged to be mildly affected died (Table 1). However, early treatment of severely affected cases with peritoneal dialysis reduced the mortality rate to 29%; this compared with an 80% mortality for severely affected patients who were not treated with dialysis. We, and others (3,4,5),have come to the conclusion that early institution of peritoneal dialysis was the most important therapeutic measure that could favourably influence the outcome of severely affected cases (Table 2).


Peritoneal Dialysis Hemolytic Uremic Syndrome Fresh Freeze Plasma Thrombotic Thrombocytopenic Purpura Cortical Necrosis 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Bernard S. Kaplan
  • Peter D. Thomson

There are no affiliations available

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