Abstract
Vascular smooth muscle is the primary target organ for Ca antagonist (CAt) therapy. It is now well established that CAts bind to and block excitable channels in the cell membrane (1). The question which remains to be answered is why are these agents selective for certain blood vessels and certain modes of activation.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Fleckenstein A: Calcium antagonism in heart and smooth muscle. John Wiley and Sons, 1983.
van Breemen C, Hwang 0, Meisheri KD: The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther (218): 459–464, 1981.
Aaronson P, vaii Breemen C: Effects of Na gradient manipulation upon cellular Ca, 45 fluxes, and cellular Na in the guinea pig taenia coli. J Physiol (319): 443–461, 1981.
van Nueten JM, Vanhoutte PM: Selectivity of calcium antagonists and serotonin antagonism with respect to venous and arterial tissues. Angiology (32): 476–484, 1981.
Droogmans G, Raeymaekers L, Casteels R: Electro and pharmacomech-anical coupling in the smooth muscle cells of rabbit ear artery. J Gen Physiol (70): 129: 48, 1977.
Saida K, van Breemen C: Mechanism of Ca2+ antagonist induced vasodilation; intracellular actions. Circ Res 52: 137–142, 1983.
Edman KAP, Schild MO: The need for calcium in the contractile responses induced by acetylcholine and potassium in the rat uterus. J Physiol (161): 424–441, 1962.
Su C, Bevan JA, Ursillo RC: Electrical quiescence of pulmonary artery smooth muscle during sympathomi stimulation. Circ Res (15): 20–27, 1964.
Droogmans G, Raeymaekers L, Casteels R: Electro and pharmacomechanical coupling in the smooth muscle cells of rabbit ear artery. J Gen Physiol (70): 129–148, 1977.
Somylo AP, Somylo AV: Vascular smooth muscle I, normal structure, Pathology, Biochemistry and Biophysics, Pharmacological Rev 20: 197–272, 1968.
Cauvin C, Loutzenhiser R, van Breemen C:: Mechanisms of calcium antagonist induced vasodilation. Ann Rev Pharmacol Toxicol 23:373–396, 1983.
Hermsmeyer K, Trapani A, Abel PW: Membrane potential-dependent tension in vascular smooth muscle. In: Vanhoutte P, Leusen I(eds)Vaodilation. Raven Press, New York, 1981, pp 273–284.
Bolton TB: Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev (3): 606–718, 1979.
van Breemen C, Aaronson P, Loutzenhiser R: Na Ca interactions in mammalian smooth muscle. Pharmacol Rev (30): 167–208, 1979.
Meisheri KD, Hwang O, van Breemen C: Evidenced for two separate Ca2+ pathways in smooth muscle plasmalemma. J Membrane Biol (59):19–25, 1981.
Kazda S, Garthoff B, Meyer H, Schlossman K, Stoepel K: Pharmacology of a new calcium antagonistic compound, isobutylmethyl, 4 dihydro 2, dimethyl (2 nitrophenyl 1) 3, 5 pyridinedicarboxylate (nisoldipine, Bay K5552). Arzneimittelforsch (30): 214–262, 1980 ).
Schramm M, Thomas G, Towart R, Frackowisali G: Novel dihydropyridines with positive isotropic action through activation of Ca+ channels. Nature (303): 535–537, 1983.
Deth R, Casteels R: A study of released Ca fractions in smooth muscle cells of the rabbit aorta. J Gen Physiol (69): 401–416, 1977.
van Breemen C: Ca requirement for activation of intact aortic smooth muscle. J Physiol (272): 317–329, 1977.
Devine CE, Somlyo AV, Somlyo AP: Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscle. J Cell Biol (52): 690–718, 1972.
Saida K, van Breemen C: A possible Ca induced Ca release mechanism mediated by norepinephrine in vascular smooth muscle. Pflugers Arch (397): 166–167, 1983.
Triggle DJ: Biochemical pharmacology of calcium blockers. IN: Calcium Blockers: Mechanisms of Action and Clinical Applications, S. Flaim and R. Zelis eds., Urban and Schwarzenberg, Baltimore, 1932, pp. 121–134.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Van Breemen, C. et al. (1984). Mechanisms of Selective CA Antagonist-Induced Vasodilation. In: Sperelakis, N., Caulfield, J.B. (eds) Calcium Antagonists. Developments in Cardiovascular Medicine, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3810-9_5
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3810-9_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3812-3
Online ISBN: 978-1-4613-3810-9
eBook Packages: Springer Book Archive