Abstract
It is now recognized that calcium channels exist in a wide variety of cells and participate in many aspects of cellular function (for review, see refs. 1 and 2). In the heart, voltage-dependent calcium ion influx underlies spontaneous activity and impulse conduction in the sinoatrial and atrioventricular nodes, maintains the plateau phase of ventricular action potentials, and is closely associated with activation of contraction (3–6). Thus, it is not surprising that compounds which block calcium channels are of considerable interest to cellular electrophysiologists and, in particular, to those interested in the electrophysiology of the heart.
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References
Hagiwara S, Byerly L: Calcium channel. Ann Rev Neurosci (4): 69–125, 1981.
Tsien RW: 1983. Calcium channels in excitable cell membranes. Ann Rev Physiol (45): 341–358, 1983.
Kass RS, Scheuer T: Slow inactivation of calcium channels in the cardiac Purkinje fiber. J Molec Cell Cardiol (14): 615–618, 1982.
Reuter H: 1979. Properties of two inward membrane currents in the heart. Ann Rev Physiol (41): 413–424, 1979.
Reuter H: Divalent cations as charge carriers in excitable membranes. Prog Biophys Mol Biol (26): 1–43, 1973.
Fozzard HA: Heart: Excitation-contraction coupling. Ann Rev Physiol (39): 201–220, 1977.
Flaim SF, Zelis R: Calcium Blockers, Mechanisms of Action and Clinial Implications. Urban and Schwarzenburg, Baltimore, Munich, 1982, p. 303.
Singh BN, Nademanee K, Baky SH: Calcium antagonists. Clinical use in the treatment of arrhythmias. Drugs (25): 125–153, 1983.
Schwartz A, Taira N: Symposium on calcium channel blocking drugs: A novel intervention for the treatment of cardiac disease. Circ Res (52) (Part II, Suppl.): 1983, 181 pp.
Janis RA, Triggle DJ: New Developments in Ca2+ channel antagonists. J Med Chem (26): 775–785, 1983.
Kass RS, Scheuer T, Malloy KJ: Block of outward current in cardiac Purkinje fibers by injection of quaternary ammonium ions. J Gen Physiol (79): 1041–1063, 1982.
Kass RS, Siegelbaum SA, Tsien RW: Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibers: Is slow inward current adequately measured? J Physiol (290): 201–225, 1979.
Kass RS: Nisoldipine: a new, more selective calcium current blocker in cardiac Purkinje fibers. J Pharm Exp Ther (223): 446–456, 1982.
Kass RS: Measurement and block of voltage-dependent calcium current in the heart. In: Merrill, GF, Weiss HR (eds) Ca2+ entry blockers, adenosine, and neurohumors. Urban and Schwarzenberg, Baltimore, 1983.
Bayer R, Hennekes R, Kaufman R, Mannhold R: Inotropic and electrophysiological actions of verapamil and D600 in mammalian myocardium. I. Pattern of inotropic effects of the racemic compounds. Naunyn-Schmiedeberg’s Arch Pharmacol (290): 49–68, 1975.
Bayer R, Kaufmann R, Mannhold R, Rodenkirchen R: The action of specific Ca antagonists on cardiac electrical activity. Prog Pharmacol (5): 53–85, 1982.
Hille B: Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol (69): 497–515, 1977.
Hondeghem LM, Katzung BG: Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta (472): 373–398, 1977.
Bean BP, Cohen CJ, Tsien RW: Lidocaine block of cardiac sodium channels. J Gen Physiol (81): 613–642, 1983.
Rodenkirchen R, Bayer R, Mannhold R: Specific and nonspecific Ca antagonists. A structure-activity analysis of cardiodepressive drugs. Prog. Pharmacol (5): 9–23, 1982.
Marban E, Tsien RW: Effects of nystatin-mediated intracellular ion substitution on membrane curents in calf Purkinje fibres. J Physiol 329: 569–587, 1982.
Colatsky TJ: Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres. J Physiol (305): 215–234, 1980.
Kass RS, Wiegers SE: Ionic basis of concentration-related effects of noradrenline on the action potential of cardiac Purkinje fibres. J Physiol (322): 541–558, 1982.
Trautwein W, Pelzer D, McDonald TF: Interval-and voltage-dependent effects of the calcium channel- blocking agents D600 and AQA 39 on mammalian ventricular muscle. Circ Res 52 (Part II, Suppl.): 160–168, 1983.
BayerR, Ehara T: Comparative studies on calcium antagonists. Prog Pharmacol. 2: 31–37, 1978
McDonald TF, Pelzer D, Trautwein W: On the mechanism of slow calcium channel block in heart. Pflugers Arch (385): 175–179, 1980
Pelzer D, Trautwein W, McDonald TF: Calcium channel block in mammalian ventricular muscle treated with organic channel inhibitors. Pflugers Arch (394): 97–105, 1982.
Lee KS, Tsien RW: Mechanism of calcium channel block by verapamil, D600, diltiazem, and nitrendipine in single dialyzed heart cells. Nature (302): 790–794, 1983
Kanaya S, Arlock P, Katzung B, Hondeghem LM: Diltiazem and verapamil preferentially block inactivated cardiac calcium channels. J Molec Cell Cardiol (15): 145–148, 1983
Kass RS, Sanguinetti MC: Calcium channel inactivation in the cardiac Purkinjie fibre: evidence for voltage- and calcium-mediated mechanisms. 1983. In Preparation.
Rowland E, McKenna WJ, Gulker H, Krikler DM: The comparative effects of diltiazem and verapamil on atrioventricular conduction and atrioventricular reentry tachycardia. Circ Res (52) (Part II, Suppl.): 1163–I168, 1983.
Rowland E, Curry P, Fox K, Krikler DM: Relation between atrioventricular pathways and ventricular response during atrial fibrillation and flutter. Br Heart J (45): 83–87, 1981.
DePonti C, Mauri F, Ciliberto GR, Caru B: Comparative effects of nifedipine, verapamil, isosorbide dinitrate and propranolol on exercise induced angina pectoris. Eur J Cardiol (10): 47–58, 1979.
Klein W, Brandt D, Vrecko K, Harringer M: Role of calcium antagonists in the treatment of essential hypertension. Circ Res 52 (Part II, Suppl.): 1174–1181, 1983.
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© 1984 Martinus Nijhoff Publishing, Boston
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Kass, R.S., Sanguinetti, M.C. (1984). Voltage Clamp Studies Of Calcium Channel Blockage in the Heart. In: Sperelakis, N., Caulfield, J.B. (eds) Calcium Antagonists. Developments in Cardiovascular Medicine, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3810-9_4
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DOI: https://doi.org/10.1007/978-1-4613-3810-9_4
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