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Effects of Inhibitors of Arachidonic Acid Metabolism and Calcium Entry on Hypoxic Contractions of the Isolated Canine Coronary Artery

  • Chapter
Calcium Antagonists

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 39))

Abstract

Constriction of large coronary arteries (coronary vasospasm) leads to an acute decrease in coronary blood flow. Although many factors [e.g. aggregating platelets (1), catecholamines (2–5), 5-hydroxytryptamine (3,4), prostaglandins (1,5-8), potassium ions (1-3,9), ergonovine maleate (3), hydroperoxides of arachidonic acid and leukotrienes (6–12), hypoxia and ischemia (3,4,13,14)] are able to cause contraction of coronary vascular smooth muscle, the exact etiology of coronary vasospasm is unknown.

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Authors
  1. Thomas J. Rimele
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  2. Paul M. Vanhoutte
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, M.L. 576, 45267, Cincinnati, OH, USA

    Nicholas Sperelakis

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© 1984 Martinus Nijhoff Publishing, Boston

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Rimele, T.J., Vanhoutte, P.M. (1984). Effects of Inhibitors of Arachidonic Acid Metabolism and Calcium Entry on Hypoxic Contractions of the Isolated Canine Coronary Artery. In: Sperelakis, N., Caulfield, J.B. (eds) Calcium Antagonists. Developments in Cardiovascular Medicine, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3810-9_22

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  • DOI: https://doi.org/10.1007/978-1-4613-3810-9_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3812-3

  • Online ISBN: 978-1-4613-3810-9

  • eBook Packages: Springer Book Archive

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