Abstract
Calcium antagonists, a heterogenous group of slow transmembrane current inhibitors, differ in their relative effect on smooth vascular muscle (relaxation), working myocardium (negative inotropic effect) and conductive tissue of the heart (negative dromotropic effect). The latter predominates after verapamil, a common antiarrhythmic drug. Nifedipine has been successfully used in the treatment of chronic ischemic heart disease because of its prevailing vasodilatatory effect (Braunwald, 1982). In addition, nifedipine appears to be a useful protective constituent of cardioplegic solutions employed during cold ischemic arrest in cardiac surgery (Clark et al, 1979). It is thus more than of theoretical interest to know the dependence of the effect of nifedipine on frequency and temperature, two variables which are deeply involved in the calcium turnover of the heart muscle cell.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bayer, R., Rodenkirchen, R., Kaufmann, R., Lee, J.H., Hennekes, R:.The effects of nifedipine on contraction and monophasic action potential of isolated cat myocardium. Naunyn Schmiedeberg’s Arch. Pharmacol. 30: 29–37 (1977).
Blinks, J.R., Koch-Weser, J.: Physical factors in the analysis of the actions of drugs on myocardial contractility. Pharm.Rev. 15: 531–599 (1963).
Braunwald, E .: Mechanism of action of calcium-channel- blocking agents. New Engl.J.Med. 307, 1918–1627 (1982).
Braveny, P., Juggi, J.S., Yousof, A,M., Telahoun, G.: Temperature and frequency dependence of the negative inotropic effect of nifedipine. J.Mo1.Cell.Cardiol. 15: (suppl.1) Abstr. 380 (1983)
Clark, R.E., Christlieb, I.Y., Henry, P.D.,Fischer, A.E., Nora, J.D., Williamson, J.R., Sobel, B.E.: Nifedipine: A myocardial protective agent. Amer.J.Cardiol. 44: 825–831(1979).
Ehara, T., Kaufmann, R.: The voltage and time dependent effects of (-) verapamil on the slow inward current in isolated cat ventricular myocardium. J. Pharma. Exp. Ther. 207: 49–55 (1978).
Goto, M., Tsuda, Y., Yatani, A., Saito, M.: Effects of low temperature on the membrane currents and tension components of bullfrog atrial muscles.Jap.J.Physiol. 28: 211–224 (1978).
Kass, R.S., Tsien, R.W.: Multiple effects of calcium antagonists on pleateau currents in cardiac Purkinje fibres. Gen. Physiol. 66: 169–192 (1975).
Kruta, V.: Sur l’activite rythmique du muscle cardiaque. II variations en fonction de la temperature. Arch. Int. Physiol. 47: 35–62 (1938).
Molyvdas, P.A., Sperelakis,N.: Comparison of the effects of several calcium antagonistic drugs (slow channel blockers) on the electrical and mechanical activities of guinea pig papillary muscle. J. Cardiovasc. Pharm. 5: 162–169 (1983).
Morgan, V.P., Wier,W.G., Hess,P., Blinks,J.R.: Influence of Ca++-channel blocking agents on calcium transients and tension development in isolated mammalian heart muscle. Circ.Res. 52(suppl. I ): 47–52 (1983).
Shattock, M.J., Hearse,D.J.: Temperature dependence of the force-frequency relationship. J. Mol. cell. Cardiol. 15 (suppl 1) Abstr. 223 (1983)
Spieckermann, P.G., Piper, H.M., Hutter, J.F.: Temperature dependent effectiveness of Ca++ antagonizing drugs. J. Mol. cell. Cardiol.(suppl 1) Abstr. 224(1983)
Yamamoto, F., Hearse, D.J.: Temperature dependency in the efficacy of calcium antagonists. J. Mol. cell. Cardiol. 15 (suppl I) Abstr. 222 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Braveny, P., Juggi, J.S., Telahoun, G. (1984). Effect of Nifedipine on Rat Papillary Muscle and Perfused Heart. In: Sperelakis, N., Caulfield, J.B. (eds) Calcium Antagonists. Developments in Cardiovascular Medicine, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3810-9_13
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3810-9_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3812-3
Online ISBN: 978-1-4613-3810-9
eBook Packages: Springer Book Archive