Abstract
The understanding of the development and treatment of hyper and hypophosphatemia requires the reader to be familiar with the various factors involved in the regulation of serum phosphorus and total body phosphorus. The reader is also referred to the excellent reviews published recently for more detailed information (1–4).
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References
Brautbar N, Lee DBN, Kleeman CR: The divalent ions. In: Freinkel N (ed) Contemporary Metabolism, Plenum Press, New York 1982, pp 441 – 526.
Lee DBN, Brautbar N, Kleeman CR: Disorders of phosphorus metabolism. In: Bronner F, Cobum JW (eds) Disorders of Mineral Metabolism, Vol III, Academic Press, New York, 1981, pp 284 – 388.
Knox FG, Osswald H, Marchand GR, Spielman WS, Hass JA, Bemdt T, Youngberg SP: Phosphate transport along the nephron. Am J Physiol 233: F261 – F268, 1977.
Lee DBN, Brautbar N, Walling MW, Carlson HE, Golvin C, Cobum JW, Kleeman CR: The biochemical indices of experimental phosphorus depletion. A re-examination of their physiological implications. In: Massry SG, Ritz E, Rapado A (eds) Homeostasis of Phosphate and Other Minerals. Plenum, New York, 1978, pp 382 – 394.
Feaster JP, Shirley RL, McCall JT, Davis GK: P32 distribution and excretion in rats fed vitamin D-free and low phosphorus diets. J Nutr 51: 381 – 392, 1953.
Copp DH, Suiker AP: Study of calcium kinetics in calcium- and phosphorus-deficient rats with the aid of radio- calcium. In: McLean FC, Lacroix P, Budy AM (eds) Radiosoptoes and Bone, Blackwell, Oxford, 1962.
Brautbar N, Baczynski R, Carpenter C, Moser S, Geiger P, Finander P, Massry SG: Impaired energy metabolism in rat myocardium during phosphate depletion. Am J Physiol 1982.
Brautbar N, Lee DBN, Cobum JW, Kleeman CR: Normophosphatemic phosphate depletion in the growing rat. Am J Physiol 236: E283 – E288, 1979.
Brautbar N, Lee DBN, Cobum JW, Kleeman CR: Soft tissue and bone mineral changes in experimental phosphate depletion: The role of growth and growth hormone. Min. Elect Metab 5: 304, 1981.
Lee DBN, Brautbar N, Walling MW, Sillis V, Carison HE, Grindland RE, Cobum JW, Kleeman CR: The role of growth hormone in experimental phosphate depletion. Calcif Tiss Int 32: 105 – 112, 1980.
Betro MG, Pain RW: Hypophosphatemia in hospital population. Br Med J 1: 273 – 276, 1972.
Massry SG, Ritz E, Verberckmoes R: Role of phosphate in the genesis of secondary hyperparathyroidism of renal failure. Nephron 18: 77 – 81, 1977.
Slatopolsky E, Robson Am, Eikan I, Bricker NS: Control of phosphate excretion in uremic man. J Clin Invest 47: 1865 – 1874, 1968.
Smith MS, Feldman KW, Fumkawa CI: Coma in an infant due to hypertonic sodium phosphate medication. J Pediatr 82: 481 – 482, 1973.
Mosel PK, Segar WE: Fluid and semm electrolyte disturbances as a complication of enema in Hirschprung’s disease. Am J Dis Child 115: 714 – 718, 1968.
Honig PJ, Holtzapple PG: Hypocalcemic tetany following hypertonic phosphate enemas. Clin Pediatr. 14: 678 – 679, 1975.
Bowman TE, Whelan TJ, Nelson TG: Sudden death after phosphoms bums: Experimental observations of hypocalcemia by phosphatemia and electrocardiographic abnor- mahties following production of a standard white phosphoms bum. Ann Surg 174: 779 – 784, 1971.
Giebisch G, Berger L, Pitts R: The extrarenal response to acute acid-base disturbances of respiratory origin. J Clin Invest 34: 231 – 245, 1955.
O’Connor LR, Klein KL, Bethune JE: Hyperphosphatemia in lactic acidosis. N Engl J Med 297: 707 – 709. 1977.
Oster JR, Perez GO, Vaamonde CA: Relationship between blood pH and potassium and phosphoms during acute metabolic acidosis. Am J Physiol. 235: F345 – F351, 1978.
Kofiler A, Friedler RM, Massry SG: Acute renal failure due to nontraumatic rhabdomyolysis. Ann Intem Med 85: 23 – 28, 1976.
Pollock RA, Watson RL: Malignant hyperthermia associated with hypocalcemia. Anesthesiology 34: 188 – 194, 1971.
Chase LR, Melson GL, Aurbach GD: Pseudohypoparathyroidism: Defective excretion of 3′5′-AMP in response to parathyroid hormone. J Qin Invest 48: 1832 – 1844, 1969.
Drezner M, Neelon FA, Lebovitz HE: Pseudohypoparathyroidism Type II: A possible defect in the reception of the cycUc AMP signal. N Engl J Med 28: 1056, 1973.
Nusynowitz ML, Frame B, Kolb FO: The spectmm of the hypoparathyroid states. A classification based on physiologic principles. Medicine [Baltimore] 55: 105 – 119, 1976.
Danowski TS: Clinical Endocrinology. Vol III, Williams & Wilkins, Baltimore.
Nassim JR, Saville PD, Mullipi L: Effect of stilboestrol on urinary phosphate excretion. Clin Sci 15: 367 – 371, 1956.
Iwanami M, Osiba S, Yamada Y, Yoshimura H: Seasonal variations in semm inorganic phosphate and calcium with special reference to parathyroid activity. J Physiol [London] 149: 23 – 33, 1959.
De Vries HR, Bijvoet OLM: Results of prolonged treatment of Paget’s disease of bone with disodium ethane- 1-hydroxy-1, 1-diphosphonate (EHDP). Neth J Med 17: 281 – 298, 1974.
Haug TO: Time course of changes in concentration of some plasma components after fiirosemide. Br Med J 3: 622, 1976.
Prince MJ, Schaefer PC, Goldsmith R, Chausmer B: Hy- perphosphatemic tumoral calcinosis. Association with elevation of semm 1,25-dihydroxycholecalciferol concentration. Ann Int med 96: 586 – 591, 1982.
Baldersson H, Evans EB, Dodge WF, Jackson WT: Tumoral calcinosis with hyperphosphatemia: A report of a family with incidence in four siblings. J Bone Joint Surg 51A: 913 – 925, 1969.
Raisz LG: The effect of factors implicated in osteopenia on bone formation and resorption in tissue culture. In: Barzel US (ed) Osteoporosis, Gmne & Stratton, New York, 1970, p 174.
Schneebeiiger EE, Morrison AB: Increased susceptibility of magnesium-deficient rats to a phosphate induced nephropathy. Am J Pathol 50: 549 – 558, 1967.
Spaulding SW, Walser M: Treatment of experimental hypercalcemia with oral phosphate. J Clin Endocrinol Metab 31: 531 – 538, 1970.
Jowsey J, Balasurbramanian P: Effect of pfeosphate supplements on soft tissue calcification and bone tumover. CUn Sci 42: 289 – 299, 1972.
Logan MA: Recent advances in the chemistry of calcification. Physiol Rev 20: 522 – 560, 1940.
Gipstein RM, Cobum JW, Adams DA, Lee DBN, Rosen SM, Sellers A, Suki WN, Massry SG: Calciphylaxis in man. A syndrome of tissue necrosis and vascular calcification in patients with chronic renal disease. Arch Intem Med 136: 1273 – 1280, 1976.
Ibels LS, Alfrey AC, Haut L, Huffer WE: Preservation of function in experimental renal disease by dietary restriction of phosphate. N Engl J Med 298: 122 – 126, 1978.
Lichtman MA, Miller DR: Erythrocyte glycolysis, 2,3- diphosphoglycerate and adenosine triphosphate concentration in uremic subjects: Relationship to extracellular phosphate concentration. J Lab Clin Med 76: 267 – 279, 1970.
Barcenas CG, Paez P, Uyeda K, Peters PC, Hull AR: Erythrocyte adenosine triphosphate and 2,3-diphosphoglycer- ate after human renal transplantation: Dissociation from hypophosphatemia. Clin Sci and Mol Med 52: 413 – 422, 1977.
Petty C, Bageant T: In vitro manipulation of 2,3-diphos- phoglycerate levels in acid-citrate-dextrose blood with steroids. Life Sci 14: 1279 – 1283, 1974.
Parfitt AM, Frame B: Phosphate loading and depletion in vitamin D treated hypoparathyroidism. In: Avioli L, Bordier PB, Fleish H, Massry S, Slatopolsky E (eds) Phosphate Metabolism, Kidney and Bone, Armour Montagu, Paris, 1976, pp 179 – 196.
Wolf AV, Remp DG, Kiley JE, Currie GO: Artificial kidney function: Kinetics of hemodialysis. J Clin Invest 40: 1062 – 1070.
Albright R, Kram B, White RP: Potassium and phosphat removal with bicarbonate hemodialysis. Proc Am Soc Nephrol 1982, 48A.
Wathen RL, Ward RA, Harding GB, Meyer LC: Acid-base and metabolic responses to anion infusion in the anesthetized dog. Kidney Int 21: 592 – 599.
Cobum JW, Hartenbower DL, Brickman AS, Massry SG, Kopple JD: Intestinal absorption of calcium, phosphorus and magnesium in chronic renal insufficiency. In: David DS (ed) Calcium Metabolism in Renal Failure. John Wiley & Sons, Inc., New York 1977, pp 79 – 109.
Aubel CE: The effects of low phosphorus rations on growing pigs. J Agric Res 52: 149 – 159, 1936.
Day HG, McCollum EV: Mineral metabolism, growth, symptomatology of rats on diet extremely deficient in phosphorus. J Biol Chem 130: 269 – 283, 1939.
Dutoit PJ, Bisschop THR: The breeding of cattle on phosphorus-deficient veld. Rep Dir Vet Serv Anim Ind, Onderstepoort 15: 1050 – 1166, 1929.
Knöchel JP: Hypophosphatemia. West J Med 134: 15 – 26, 1981.
Ryback R, Eckardt MH, Paulter CP: Clinical relationship between serum phosphorus and other blood chemistry values in alcoholics. Arch Intern Med 140: 673, 1980.
Annino JS, Relman AS: The effect of eating on some of the clinically important chemical constituents of the blood. Am J Clin Pathol 31: 155 – 159, 1959.
Silvis SE, Paragas PV, Jr: Fatal hyperalimentation syndrome. Animal studies. J Lab Clin Med 78: 918 – 930, 1971.
Silvis SE, Paragus PD, Jr: Parasthesias weakness, seizures and hypophosphatemia in patients receiving hyperalimentation. Gastroenterology 62: 513 – 520, 1972.
Mollison PL: Observations on cases of starvation at Belsen. Br Med 1: 4 – 8, 1946.
Strickler JC, Thompson DD, Klose RM, Giebisch G: Micropuncture study of inorganic phosphate excretion in the rat. J CHn Invest 43: 1596 – 1670, 1964.
Mostellar ME, Tuttle EP, Jr: The effects of alkalosis on plasma concentration and urinary excretion of phosphate in man. J Clin Invest 43: 138 – 149, 1964.
Brautbar N, Leibovici H, Massry SG: On the mechanism of hypophosphatemia during acute hyperventilation: Evidence for increased muscle glycolysis. Min Elect Metab 9: 45 – 50, 1983.
Dominguez JH, Gray RW, Lemann J, Jr: Dietary phosphate deprivation in women and men: Effects on mineral and acid balances, parathyroid hormone and the metabolism of 25-OH-vitamin D. J Clin Endocrinol Metab 43: 1056 – 1068, 1976.
Bloom WL, Finchum D: Osteomalacia with pseudofractures caused by the ingestion of aluminium hydroxide. JAMA 174: 181 – 184, 1960.
Lötz M, Zisman E, Bartter FC: Evidence for phosphorus depletion syndrome in man. N Engl J Med 278: 409 – 415, 1968.
Leaf A: The syndrome of osteomalacia, renal glycosuria, aminoaciduria, and hyperphosphaturia (The Fanconi Syndrome). In: Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The Metabolic Basis of Inherited Disease, 2nd edn, McGraw-Hill, New York, 1966, pp 1205 – 1220.
Anderson J, Foster JB: Effect of cortisone on urinary phosphate excretion in man. Clin Sei 18: 437 – 439, 1959.
Guest GM: Organic phosphates of the blood and mineral metabolism in diabetic acidosis. Am J Dis Child 64:410– 412, 1942.
Scriver CR: Rickets in the pathogenesis of impaired tubular transport of phosphate and other solutes. Am J Med 57: 43 – 49, 1966.
Morgan DB: Calcium and phosphorus transport across the intestine. In: Girdwood RH, Smith AN (eds). Malabsorption, Williams & Wilkins, Baltimore, Maryland, 1978, pp 73 – 95.
Eraser D, Scriver CR: Familial forms of vitamin D-resis- tant rickets revisited X-linked hypophosphatemia and autosomal recessive vitamin D dependency. Am J Clin Nutr 29: 1315 – 1329, 1976.
Stein JH, Smith WO, Ginn HE: Hypophosphatemia in acute alcoholism. Am J Med Sei 252: 78 – 83, 1966.
Frank BW, Kern F Jr: Serum inorganic phosphorus during hepatic coma. Arch Intern Med 110: 865 – 871, 1962.
Whang R, Weh LG: Observations in experimental magnesium depletion. J Clin Invest 42: 305 – 313, 1963.
Brautbar N, Baczynski R, Carpenter C, Moser S, Geiger P, Einander P, Massry SG: Impaired energy metabolism in rat myocardium during phosphate depletion. Am J Physiol 242: F699 – F704, 1982.
Brautbar N, Carpenter C, Baczynski R, Kohan R, Massry SG: Effects of phosphate depletion on skeletal muscle energy metabolism during phosphate depletion. Kidney Intl (in Press).
Gold LW, Massry SG, Friedler RM: Effect of phosphate depletion on renal tubular reabsorption of glucose. J Lab Clin Med 89: 554 – 559, 1977.
Harter HR, Mercado A, Rutherford WE, Rodriguez H, Slatopolsky E, Klahr S: The relative role of calcium, phosphorus, and parathyroid hormone in glucose and tolbu- tamide-mediated insulin release. J Clin Invest 58:359– 362.
Davis JL, Lewis SB, Schultz TA, Kaplan RA, Wallin JD: Acute and chronic phosphate depletion as a modulator of glucose uptake in rat skeletal muscle. Life Sei 24: 629 – 632, 1979.
De Fronzo RA, Lang R: Hypophosphatemia and glucose intolerance: Evidence for tissue insensitivity to insulin. N Engl J Med 303: 1259, 1980.
Brautbar N, Leibovici H, Einander P, Massry SG: Evidence that the hypophosphatemia of acute hyperventilation is due to increased muscle glycolysis. Clin Res 29: 93A, 1981b.
Hörle WH, Kreusser W, Heidland A, Ritz E: Abnormalities of glycogen metaboUsm in cardiomyopathy of phosphorus depletion. In: Massry SG, Ritz E, Jahn H (eds). Phosphate and Minerals in Health and Disease, Plenum Press, New York, 1979, pp 343 – 350.
Fuller TJ, Carter NW, Barcenas C, Knöchel JP: Reversible changes of the muscle cell in experimental phosphorus deficiency. J Clin Invest 57: 1019 – 1024, 1976.
Ramsay AM, Douglas LJ: Effects of phosphate limitation of growth on the cell-wall and lipid composition of Saccharomyces cerevisiae, J Gen Microbiol 110: 185 – 191, 1979.
Brautbar N, Tabemero-Romo J, Coats J, Massry SG: Myocardial fatty acid oxidation and phospholipid metabolism during phosphate depletion. Clin Res 31: 52A, 1983.
Moser S, Brautbar N, Gura V, Kleeman CR, Massry SG: On the mechanism of hypophosphaturia during acute and chronic dietary phosphate restriction. Min Elect Metab 5: 39 – 48, 1981.
Cuisinier-Gleizes P, Thomasset M, Mathieu H: Homeostasis and P and Ca in phosphorus deprivation. In: Avioli L, Bordier PH, Fleish H, Massry SG, Slatopolsky E (eds), Phosphate Metabolism, Kidney and Bone, Nouvelle Imprimerie Foumie, Paris, 1975, pp 381 – 386.
Lau K, Agus ZS, Goldberg M, Goldfarb S: Renal tubular sites of altered calcium transport in phosphate-depleted rats. J Clin Invest 64: 1681, 1979.
Meyer-Sabellek W, Brautbar N, Moser S, Montcalm A, Massry SG: Effect of thiazides on the hypercalciuria of phosphate depletion. J Lab Qin Med 96: 830 – 837, 1980.
Cuisinier-Gleizes P, George, A, Giuliano C, Mathieu H: Effet osteolytique de regime pauvre en phosphore chez le rat. In: Hioco DJ (ed) Phosphate et Metabolisme Phosphocalcique. Editions Sandoz, Paris, 1971, pp 117 – 125.
Brautbar N, Walling MW, Cobum JW: Interactions between vitamin D deficiency and phosphorus depletion in the rat. J CUn Invest 63: 335 – 341, 1979b.
Grabie M, Lau K, Agus ZS, Goldberg M, Goldfarb S: The role of parathyroid hormone in the hypercalciuria of chronic phosphate depletion. Min Elect Metab 1: 279, 1978.
Brautbar N, Lee DBN, Cobum JW, Kleeman CR: Influence of dietary magnesium in experimental phosphate depletion: Bone and soft tissue mineral changes. Am J Physiol 237: E152 – E157, 1979.
Arruda JAL, Julka NK, Rubinstein H, Sabatini S, Kurtzman NA: Distal acidification defect induced by phosphate deprivation. Metabolism 29: 826 – 836, 1980.
Gold LW, Massry SG, Arieff AI: Renal bicarbonate wasting during phosphate depletion. A possible cause of altered acid-base homeostasis in hyperparathyroidism. J Clin Invest 52: 2556 – 2562, 1973.
Emmett M, Goldfarb S, Agus ZS, Narins RG: The pathophysiology of acid-base changes in chronically phosphate- depleted rats. Bone-kidney interaction. J Clin Invest 59: 291 – 298, 1977.
Yu HL, Giammarco R, Goldstein MB: Stimulation of ammonia production and excretion in the rabbit by inorganic phosphate. J Clin Invest 58: 577 – 584, 1976.
Travis SF, Sugerman HJ, Ruberg RL, Dudrick SJ, Delivoria-Papadopoulos M, Miller LD: Alterations of red cell glycolytic intermediates and oxygen transport as a consequence of hypophosphatemia in patients receiving intravenous hyperalimentation. N Engl J Med 285: 763 – 768, 1971.
Ditzel J: Effect of plasma inorganic phosphate on tissue oxygenation during recovery from diabetic ketoacidosis. Adv Exp Med Biol 37A: 163 – 172, 1971.
Yawata Y, Hebbel RP, Silvis S, Howe R, Jacob H: Blood cell abnormalities complicating the hypophosphatemia of hyperalimentation: Erythrocyte and platelet ATP deficiency associated with hemolytic anemia and bleeding in hyperalimented dogs. J Lab Clin Med. 84: 643 – 653, 1974.
Jacob HS, Amsden T: Acute hemolytic anemia with riged red cells in hypophosphatemia. N Engl J Med 385:1446– 1450, 1971.
Craddock PR, Yawata Y, Van Santen L, Gilberstadt S, Silvis S, Jacob HS: Acquired phagocyte dysfunction. A complication of the hypophosphatemia of parenteral hyperalimentation. N Engl J Med 290: 1403 – 1407, 1974.
Gamer GB, Heubner PF, O’Dell BL: Dietary phosphoms and salmonellosis in guinea pigs. Fed Proc Fed Am Soc Exp Biol 26: 799, 1967.
O’Connor LR, Wheeler WS, Bethune JE: Effect of hypophosphatemia on myocardial performance in man. N Engl J Med 297: 901 – 903, 1978a.
Fuller TJ, Nichols WW, Brenner BJ, et al: Reversible depression in myocardial performance in dogs with experimental phosphoms depletion. J Clin Invest 62:1194– 1200, 1978.
Darsee JR, Nutter DO: Reversible severe congestive cardiomyopathy in three cases of hypophosphatemia. Ann Intern Med 89: 867, 1978.
Schneider H, Steambock H: A low phosphoms diet and the response of rats to vitamin D3. J Biol Chem 128:159– 171, 1939.
Newman JH, Nefif TA, Ziporin A: Acute respiratory failure associated with hypophosphatemia. N Engl J Med 296: 1101 – 1103, 1977.
Planas RF, McBrayer RH, Keen PA: Effects of hypophosphatemia on pulmonary muscle performance. In: Regulation of Phosphate and Mineral Metabolism, Vol 151, 1982, pp 283 – 290.
Theiler A, Green HH: Aphosphorosis in mminants. Nutr Abstr Rev 1: 359 – 391, 1932.
Baylink D, Wergedal J, Stauffer M: Formation, mineralization and resorption of bone in hypophosphatemic rats. J Clin Invest 50: 2519 – 2530, 1971.
Vemejoul de CM, Marie P, Kuntz D, Gueris J, Miravet L, Ryckewaert A: Nonosteomalacic osteopathy associated with chronic hypophosphatemia. Calcif Tiss Int 34:219– 223, 1982.
Rosen R, Leach W, Ariefif A: Central nervous system dysfunction and hypophosphatemia (HP). Kidney Int 12: 460 (abstract), 1977.
Atchley DW, Loeb LF, Richards DW, Jr, Benedict EM, Driscoll ME: On diabetic acidosis. A detailed study of electrolyte balances following the withdrawal and reestablishment of insulin therapy. J Clin Invest 12: 297 – 326, 1933.
Friedlander K, Rosenthal WG: Uber der einflub des phosphorsaure ions auf den bluntund hamsucker des normalen und des diabetischen Organismus. Naumyn- Schmiedebergs Arch Exp Pathol Pharmakol. 112: 66 – 81, 1926.
Franks M, Berris RF, Kaplan NO: Metabolie studies in diabetic acidosis. II. The effect of the administration of sodium phosphate. Arch Intem Med 82: 42 – 55, 1948.
Ditzel J: Importance of plasma inorganic phosphate on tissue oxygenation during recovery from diabetic ketoacidosis. Horm Metab Res 5: 471 – 472, 1973.
Sterling MA: Diabetic ketoacidosis in childhood. Pediatr Clin North Amer 26: 152 – 168, 1979.
Gibby OM, Veale KEA, Hayes TM, Jones JG, Wardrop CAJ: Oxygen availability from the blood and the effect of phosphate replacement on erythrocyte 2,3-diphosphoglycerate and haemoglobbin-oxygen affinity in diabetic ketoacidosis. Diabetologia 15: 381 – 385, 1978.
Keller U, Berger W: Prevention of hypophosphatemia by phosphate infiision during treatment of diabetic ketoacidosis and hyperosmolar coma. Diabetic 29: 87 – 95, 1980.
Swaminathan R, Bradley P, Morgan DB, Hill GL: Hypophosphatemia in surgical patients. Surg Gynecol Obstet 148: 448 – 454, 1979.
Hessov I, Jensen NG, Rasmussen A: Prevention of hypophosphatemia during post-operative routine glucose administration. Acta Chir Scand 146: 109 – 114, 1980.
Lennquist S, Lindell B, Nordstrom N, Sjoberg: Hypophosphatemia in severe bums. Acta Chir Scand 145: 1 – 6, 1979.
Garabedian M, Silve C, Levy D, Bourdeau A, Ulmann A, Broyer M, Balsan S: Chronic hypophosphatemia in kidney transplanted children and young adults. In: Phosphate and Minerals in Health and Disease SG, Massry E, Ritz H, Jahn, (eds), pp 249 – 254, Plenum Press, New York, 1979.
Farrington K, Varghese Z, Newman SP, Ahmed KY, Fernando ON, Moorhead JF: Dissociation of absorption of calcium and phosphate after successful cadaveric renal transplantation. Br Med 17: 712 – 714, 1979.
Walker GS, Peacock M, Marshall DH, Giles GR, Davison AM: Factors influencing the intestinal absorption of calcium phosphorus following renal transplantation. Nephron 26: 225 – 229, 1980.
Kovarik J, Graf H, Stummvoll HK, Wölk A, Pinggera WF: Tubular phosphate-handling after successfiil kidney transplantation. Klin Wochenschr 58: 863 – 869, 1980.
Brooks MH, Bell NH, Love L, Stem PH, Orfei E, Queener SF, Hamstra AJ, DeLuca HF: Vitamin D-dependent rickets type II: Resistance of target organs to 1,25-dihydroxy- vitamin D. N Engl J Med 298: 996 – 999, 1978.
Zerwekh JE, Glass K, Jowsey J, Pak YC: An unique form of osteomalacia associated with end organ refractoriness to 1,25-dihydroxyvitamin D and apparent defective synthesis of 25-hydroxyvitamin D. J Clin Endocrinol Metab 49: 171 – 175, 1979.
Liberman UA, Halabe A, Samuel R, Kauli R, Edelstein S, Weisman Y, Papapoulos SE, Clemens TL, Fraher U, O’riordan JLH: End-organ resistance to 1,25-hydroxycholecalciferol. Uncet 1: 504 – 506, 1980.
Glorieux FH, Marie PJ, Pettipor JM, Delvin EE: Bone response to phosphate salts, ergocalciferol and calcitriol in hypophosphatemic vitamin D-resistant rickets. N Engl J Med 303: 1023 – 1031, 1980.
Fujita T, Nomura M, Okajuma S, Furuya H: Adult-onset vitamin D-resistant osteomalacia with the unresponsiveness to parathyroid hormone. J Clin Endocrinol Metab 50: 927 – 931, 1980.
Chan JMC, Lovinger RD, Mamunes P: Renal hypophosphatemic rickets: Growth acceleration after long term treatment with l,25-dihydroxyvitamin-D3. Pediatrics 66: 446 – 454, 1980.
Nortman DF, Cobum JW, Brautbar N, Sherrard DJ, Haussler MR, Singer FR, Brickman AS, Barton RT: Treatment of mesenchymal tumor associated osteomalacia (MTAO) with 1,25[0H)2D3: Report of a case. In: Norman AW, Schaefer K, Herrath DV, Grioleit HG, Cobum JW, DeLuca HF, Mawer EB, Suda T, (eds) Vitamin D: Basic Research and Its Clinical Application, Walter de Gruyter, Berlin, New York, 1979, pp 1167 – 1169.
Fukumoto T, Tarui S, Tsukiyama K, Ichehara, Moriwaki K, Nonaka K, Mizushima T, Kobayashi T, Dokoh S, Fukunaga M, Tamarita R: Tumor induced vitamin D- resistant hypophosphatemic osteomalacia associated with proximal renal tubular dysfimction and 1,25–dihydroxyvitamin D deficiency. J Clin Endocrinol Metab 49:873– 878.
Walker GS, Davidson AM: Predition of post dialysis hypophosphatemia. Br Med J 2: 1060 – 1061, 1977.
Ahmed KY, Wills MR, Skinner RK, Varghese Z, Meinhard E, Baillod RA, Moorehead JF: Persistent hypophosphatemia and osteomalacia in dialysis patients not on oral phosphate binders: Respnse to DHF. Lancet 2: 439 – 442, 1976.
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Brautbar, N., Kleeman, C.R. (1984). Hyper- and Hypophosphatemia. In: Suki, W.N., Massry, S.G. (eds) Therapy of Renal Diseases and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3807-9_8
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