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Renal Tubular Acidosis

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Therapy of Renal Diseases and Related Disorders

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Abstract

The body maintains normal acid-base equilibrium by respiratory and renal control of buffers, especially bicarbonate. The respiratory system influences acid-base equilibrium by hyperventilation, with primary or secondary respiratory alkalosis (with low PCO2), or by hypoventilation, leading to respiratory acidosis (with very high PCO2). The kidney is the body’s other major site for acid-base control. Daily the kidney normally accounts for secretion of 4500 mEq of acid/1.73 m2 in exchange for the reabsorption of all filtered bicarbonate and, in addition, the secretion of 1–2 mEq/kg acid in the form of titrable acid and ammonium. A brief review of how the normal kidney performs this acidification will be necessary to consider adequately the appropriate therapeutic responses to the renal tubular acidoses.

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Authors
  1. Elisabeth M. McSherry
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Editor information

Editors and Affiliations

  1. The Bernard J. Hanley, Los Angeles, CA, 90033, USA

    Wadi N. Suki M.D. (Professor of Medicine Professor of Physiology and Biophysics Chief) (Professor of Medicine Professor of Physiology and Biophysics Chief)

  2. Division of Nephrology, University of Southern California School of Medicine, Los Angeles, CA, 90033, USA

    Wadi N. Suki M.D. (Professor of Medicine Professor of Physiology and Biophysics Chief) (Professor of Medicine Professor of Physiology and Biophysics Chief)

  3. Renal Section Baylor College of Medicine, The Methodist Hospital, Houston, TX, 77030, USA

    Shaul G. Massry M.D. (Professor of Medicine and Physiology Chief) (Professor of Medicine and Physiology Chief)

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© 1984 Martinus Nijhoff Publishing, Boston/ The Hague/ Dordrecht/ Lancaster

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McSherry, E.M. (1984). Renal Tubular Acidosis. In: Suki, W.N., Massry, S.G. (eds) Therapy of Renal Diseases and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3807-9_11

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  • DOI: https://doi.org/10.1007/978-1-4613-3807-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3809-3

  • Online ISBN: 978-1-4613-3807-9

  • eBook Packages: Springer Book Archive

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