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Molecular Basis of Guanidine Action

  • Chapter
Antiviral Drugs and Interferon: The Molecular Basis of Their Activity

Part of the book series: Developments in Molecular Virology ((DMVI,volume 4))

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Abstract

Guanidine and guanidinium compounds such as arginine, citrulline, ornithine, and creatine are natural constituents of animal cells and serum. It was discovered independently by Rightsel et al. (1), Crowther and Melnick (2), and Ueda et al. (3) that the replication of polioviruses in tissue culture was inhibited by guanidine at millimolar (mM) concentrations. Guanidine is a basic compound which exists at physiological pH as a resonance hybrid with a net positive charge. It has long been used at molar concentrations as a protein denaturant and dissociating agent, and it has therefore been inferred that its specific antiviral activity is the result of an induced conformational change in a viral product which is extremely sensitive to the denaturant.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Albany Medical College of Union University, Albany, N.Y., USA, 12208

    M. Schrom & L. A. Caliguiri

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  1. M. Schrom
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  2. L. A. Caliguiri
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  1. The Hebrew University of Jerusalem, Israel

    Yechiel Becker

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© 1984 Martinus Nijhoff Publishing, Boston

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Schrom, M., Caliguiri, L.A. (1984). Molecular Basis of Guanidine Action. In: Becker, Y., Hadar, J. (eds) Antiviral Drugs and Interferon: The Molecular Basis of Their Activity. Developments in Molecular Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3804-8_16

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  • DOI: https://doi.org/10.1007/978-1-4613-3804-8_16

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