Early Morphologic Markers of Carcinogenicity in Rat Pancreas

  • Daniel S. Longnecker
Part of the Environmental Science Research book series (ESRH, volume 29)

Abstract

Carcinomas have been experimentally induced in the pancreas of rats by several chemicals since Hayashi and Hasegawa first reported induction of hyperplastic nodules and acinar cell adenomas in pancreas of rats treated with 4-hydroxyaminoquinoline-1-oxide (4-HAQO) (1). Induction of exocrine pancreatic carcinomas by azaserine, 7,12-dimethylbenz(a)anthracene, and 4-HAQO has been been studied to an extent that each can be regarded as providing a model in rats. Of these three, the azaserine-rat model has been best characterized and can be regarded as a prototype for carcinogenesis by chemicals that appear primarily to affect acinar cells and lead to their transformation. This model will be described in detail and compared with other models that will be less completely described.

Keywords

Pancreatitis Quinoline Noma Retinoid Phenoxy 

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Daniel S. Longnecker
    • 1
  1. 1.Department of PathologyDartmouth Medical SchoolHanoverUSA

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