Abstract
Syngeneic (C3H/HeN) antisera to two in vitro chemically transformed cell lines (DMBA CI 2 and MCA CI 15), and to early embryo cells, as well as sera from multiparous C3H mice, have been found to react with a variety of in vitro transformed cell derived from C3H/10T1/2C1 8 mouse embryo fibroblasts, using an 125I-protein A binding assay or immunofluorescence. The degree of this antibody reactivity is correlated positively with the ability of the cells to exhibit anchorage-independent growth. Thus it seems that those cells which grow poorly in agarose will have low binding activities with syngeneic antisera or multiparous serum.
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© 1983 Plenum Press, New York
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Lee, F.H., Heidelberger, C. (1983). Detection and Identification of Common Oncofetal Antigens on in Vitro Transformed Mouse Fibroblasts. In: Milman, H.A., Sell, S. (eds) Application of Biological Markers to Carcinogen Testing. Environmental Science Research, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3790-4_42
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DOI: https://doi.org/10.1007/978-1-4613-3790-4_42
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