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Gamma-Glutamyl Transpeptidase Expression in Neoplasia and Development

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Application of Biological Markers to Carcinogen Testing

Part of the book series: Environmental Science Research ((ESRH,volume 29))

Abstract

Since the discovery (34) that gamma-glutamyl transpeptidase (GGT) can serve as a positive histochemical marker of putative preneoplastic hepatocyte foci and of hepatocellular carcinomas in rats treated with aflatoxin B1, this enzyme has assumed greater and greater importance as a marker of neoplasia in liver and in several other tissues. The present paper reviews some of the proposed functions of GGT, recent findings on its regulation, characteristics of its expression during carcinogenesis, and recent evidence implicating GGT as a marker of cell differentiation or aging in normal tissues.

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  1. McArdle Laboratory, University of Wisconsin, Madison, Wisconsin, USA

    William L. Richards

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  1. United States Environmental Protection Agency, Washington, D.C., USA

    Harry A. Milman

  2. University of Texas Health Science Center, Houston, Texas, USA

    Stewart Sell

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Richards, W.L. (1983). Gamma-Glutamyl Transpeptidase Expression in Neoplasia and Development. In: Milman, H.A., Sell, S. (eds) Application of Biological Markers to Carcinogen Testing. Environmental Science Research, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3790-4_17

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