A View from the Bridge: Antigenic Determinants in Immunoregulation

  • Douglas R. Green
  • Richard K. Gershon

Abstract

Although Louis Pasteur was not the first person to apply the principles of immunity, he was the first immunologist since he emphasized the role of antigen to immune responses (though he misinterpreted this role, it was nevertheless a landmark discovery). Since that time, immunologists have worked to dissect the immune response from both ends, that is, to ascertain the various components of the interacting forces of the immune system and to discover the roles that each portion of the antigen have in eliciting these effects.

Keywords

Anemia Myeloma Lysozyme Schiff Seco 

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References

  1. 1.
    K. Landsteiner, “The Specificity of Serological Reactions,” Springfield, Ill., Thomas, (1936).Google Scholar
  2. 2.
    Z. Ovary and B. Benacerraf, Immunological specificity of the secondary response with dinitrophenylated proteins. Proc. Soc.Exp.Biol., N.Y. 114:72 (1963).PubMedGoogle Scholar
  3. 3.
    H. N. Claman, E. A. Chaperon and R. F. Triplett, Thymus-marrow cell combination: Synergism in antibody production. Proc. Soc.Exp.Biol., N.Y. 122:1167 (1966).PubMedGoogle Scholar
  4. 4.
    A. J. S. Davies, E. Leuchars, V. Wallis, R. Marchant and E. V. Elliot, The failure of thymus derived cells to produce antibody. Transplantation 5: 222 (1967).CrossRefGoogle Scholar
  5. 5.
    N. A. Mitchison, Antigen recognition responsible for the induction in vitro of the secondary response. Cold Sring Harbor Symp. Quant. Biol., 32:431 (1967).Google Scholar
  6. 6.
    R. Rajewsky, Tolerance specificity and the immune response to lactic dehydrogenase isoenzymes, Cold Spring Harbor Symp. Quant.Biol. 32:547 (1967).Google Scholar
  7. 7.
    G. F. Mitchell and J. F. A. P. Miller, Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J.Exp.Med. 128: 821 (1968).PubMedCrossRefGoogle Scholar
  8. 8.
    N. A. Mitchison, Mechanism of action of antilymphocyte serum. Fed.Proc. 29: 222 (1970)PubMedGoogle Scholar
  9. 9.
    G. M. Iverson, The ability of CBA mice to produce anti-idiotype to 5563 myeloma protein. Nature 227: 273 (1970).PubMedCrossRefGoogle Scholar
  10. 10.
    G. Möller, (ed) Regulatory role of antigenic determinants. Immunol.Rev. Vol. 39 (1978).Google Scholar
  11. 11.
    R. K. Gershon, D. D. Eardley, S. Durum, D. R. Green, F. W. Shen, K. Yamauchi, H. Cantor and D. B. Myrphy, Contrasuppression: A novel immunoregulatory activity. J.Exp.Med. 153: 1533 (1981)PubMedCrossRefGoogle Scholar
  12. 12.
    D. R. Green, R. K. Gershon D. D. Eardley, Functional deletion of different Ly-1 T cell inducer subset activities by Ly-2 suppressor T lymphocytes. Proc.Natl.Acad.Sci.USA 78: 3819 (1981)PubMedCrossRefGoogle Scholar
  13. 13.
    D. R. Green, D. D. Eardley, A. Kimura, D. B. Murphy, K. Yamauchi and R. K. Gershon, Immunoregulatory circuits which modulate responsiveness to suppressor cell signals: Characterization of an effector cell in the contrasuppressor circuit. Eur.J. Immunol, (in press).Google Scholar
  14. 14.
    M. Fresno, G. Nabel, L. McVay-Boudreau, H. Furthmayr and H. Cantor, Antigen specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity. J.Exp.Med. 153: 1246 (1981).PubMedCrossRefGoogle Scholar
  15. 15.
    G. M. Iverson, D. D. Eardley, C. A. Janeway and R. K. Gershon, Isolation of circulating IgT with the use of anti-idiotype immunoabsorbants. Proc.Natl.Acad.Sci.USA in press (1981).Google Scholar
  16. 16.
    C. Schiff, Regulation of the murine immune response to sheep red blood cells: The effects of educating lymphocytes in vitro with glycoproteins isolated from the sheep erythrocyte membrane, M.D. Thesis, Yale University School of Medicine, (1980).Google Scholar
  17. 17.
    L. Adorini, M. A. Harvey, A. Miller and E. E. Sercarz, The fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg white lysozyme (HEL) in a genetically non-responder mouse strain. J.Exp.Med. 150: 293 (1979).PubMedCrossRefGoogle Scholar
  18. 18.
    L. S. Wicker, C. D. Benjamin, M. E. Katz, E. E. Sercarz and A. Miller, The similar and highly restrictive epitope specificity of Ts and primary B cells, (ABSTR) Fed.Proc. 41: 302 (1980).Google Scholar
  19. 19.
    D. R. Green and R. K. Gershon, Regulatory T cells in hyperimmune mice, manuscript in preparation.Google Scholar
  20. 20.
    C. R. Parish, Appearance of non-specific suppressor T cells during in vitro culture, Immunology 33: 597 (1977).PubMedGoogle Scholar
  21. 21.
    B. Benacerraf and R. N. Germain, The immune response genes of the major histocompatibility complex, Immunol.Rev. 38: 70 (1978).PubMedCrossRefGoogle Scholar
  22. 22.
    E. E. Sercarz, R. L. Yowell and L. Adorini, Immune response genes control the helper-suppressor balance, in “Immune System: Genetics and Regulation,” (E.E. Sercarz, L.A. Herzenberg and C.F. Fox, eds), Academic Press, New York (1977).Google Scholar
  23. 23.
    K. Yamauchi, D. R. Green, D. D. Eardley, D. B. Murphy and R. K. Gershon, Immunoregulatory circuits that modulate responsiveness to suppressor cell signals: The failure of BIO mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit, J.Exp.Med. 153: 1547Google Scholar
  24. 24.
    J. S. Britz, P. W. Askenase, W. Ptak, R. M. Steinman and R. K. Gershon, Specialized antigen-presenting cells: Splenic dendritic cells, and peritoneal exudate cells induced by mycobacteria active effector T cells that are resistant to suppression. J.Exp.Med, 155:1344Google Scholar
  25. 25.
    W. O. Weigle, Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens, J.Exp.Med. 116: 913 (1962).PubMedCrossRefGoogle Scholar
  26. 26.
    R. K. Gershon and K. Kondo, Tolerance to sheep red cells: Breakage with thymocytes and horse red cells, Science 175: 996 (1972)PubMedCrossRefGoogle Scholar
  27. 27.
    C. A. Janeway, Jr., B. Broughton, E. Dzierzak, B. Jones, D.D. Eardley, S. Durum, K. Yamauchi, D. R. Green and R. K. Gershon, Studies of T lymphocyte function in B cell deprived mice, in “Immunoglobulin Idiotypes and their Expression. ICN-UCLA Symposia on Molecular and Cellular Biology,” Vol. XX (C.A. Janeway, Jr., E.E. Sercarz, H. Wigzell and C. F. Fox, eds), Academic Press, NY. 661 (1981).Google Scholar
  28. 28.
    U. Hurtenbach, D. H. Sachs and G. M. Shearer, Protection against graft versus host associated immunosuppression in Fi mice. I. Activation of Fi regulatory cells by host specific anti-MHC antibodies, J.Exp.Med. 155:1344.Google Scholar
  29. 29.
    L. A. Herzenberg, Allotype suppression and epitope specific regulation, Immunol.Today, in press.Google Scholar
  30. 30.
    C. Henry and N. K. Jerne, Competition of 19S and 7S antigen receptors in the regulation of the primary immune response, J.Exp.Med. 128: 133 (1968).PubMedCrossRefGoogle Scholar
  31. 31.
    M. Feldmann, P. Beverley, P. Erb, S. Howie, S. Kontiainen, A. Maoz, M. Mathies, I. McKenzie and J. Woody, Current concepts of the antibody response — heterogeneity of lymphoid cells, interactions, and factors, Cold Spring Harbor Symp.Quant.Biol. 41:113 (1976).Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Douglas R. Green
    • 2
  • Richard K. Gershon
    • 1
  1. 1.Departments of Pathology and BiologyYale University School of MedicineNew HavenUSA
  2. 2.Laboratory of Cellular Immunology, Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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