The Sorting-Out Problem in Antigen Presentation
It has become increasingly clear in recent years that there exists a severe restriction in antigen presentation to a large class of T cells. Even when so unrestricted an assay as induction of proliferation (as opposed to generation of help) is used, it is generally found that only small regions (and, in many cases, a single region) of protein antigens are presented. Such a result is amply illustrated in this volume in the papers of Lin et al.; Berkower et al.; Thomas et al.; Krzych et al.; Rude et al.; and Corradin et al.
KeywordsPeptide Fragment Cyanogen Bromide Cell Proliferative Response Peptide Frag Cyanogen Bromide Cleavage
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