The Sorting-Out Problem in Antigen Presentation
It has become increasingly clear in recent years that there exists a severe restriction in antigen presentation to a large class of T cells. Even when so unrestricted an assay as induction of proliferation (as opposed to generation of help) is used, it is generally found that only small regions (and, in many cases, a single region) of protein antigens are presented. Such a result is amply illustrated in this volume in the papers of Lin et al.; Berkower et al.; Thomas et al.; Krzych et al.; Rude et al.; and Corradin et al.
KeywordsHydrolysis Bromide Turkey Lysozyme Carboxy
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- 2.B. Banacerraf, A hypothesis to relate the specificity of T lymphocytes, J. Immunol. 120:1809–1812 (1978).Google Scholar
- 3.A. Miller, A model implicating altered macrophage function in H-2 linked nonresponsiveness to hen lysozyme, in:“Immunobiology of Proteins and Paptides-I,” (Adv. exp. med. biol. 98) (M.A. Atassi and A. B. Stavitsky), p. 131–139, Plenum Press, New York (1978).Google Scholar
- 4.D. E. Kipp, L. Adorini, S. Hill, A. Miller and E. E. Sercarz, Partial overlap of Ir gene-controlled responses to two proteins of limited relatedness: hen egg-white lysozyme and human lysozyme, Ann. Immunol. 131: 311–325 (1980).Google Scholar
- 5.J. Klein, Genetic control of immune response, in:“Biology of the mouse histocompatibility-2 complex,” p.411–448, Springer-Verlag, New York (1975).Google Scholar
- 6.L. B. Peterson, G. D. Wilner and D. W. Thomas, Murine T lymphocyte proliferative responses to human fibrinopeptide B, Fed. Proc. 39:1127 (1980).Google Scholar
- 7.M. E. Katz, R. M. Maizels, B. A. Araneo, A. Miller and E. E. Sercarz, The MHC regulates different specificity restrictions in the T cell proliferative response of mice to the lysozymes, Fed. Proc. 39:1127 (1980).Google Scholar