Skip to main content

The Sorting-Out Problem in Antigen Presentation

  • Chapter
Protein Conformation as an Immunological Signal
  • 44 Accesses

Abstract

It has become increasingly clear in recent years that there exists a severe restriction in antigen presentation to a large class of T cells. Even when so unrestricted an assay as induction of proliferation (as opposed to generation of help) is used, it is generally found that only small regions (and, in many cases, a single region) of protein antigens are presented. Such a result is amply illustrated in this volume in the papers of Lin et al.; Berkower et al.; Thomas et al.; Krzych et al.; Rude et al.; and Corradin et al.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A. S. Rosenthal, Determinant selection and macrophage function in genetic control of the immune response, Immunol. Rev. 40: 136–152 (1978).

    Article  PubMed  CAS  Google Scholar 

  2. B. Banacerraf, A hypothesis to relate the specificity of T lymphocytes, J. Immunol. 120:1809–1812 (1978).

    Google Scholar 

  3. A. Miller, A model implicating altered macrophage function in H-2 linked nonresponsiveness to hen lysozyme, in:“Immunobiology of Proteins and Paptides-I,” (Adv. exp. med. biol. 98) (M.A. Atassi and A. B. Stavitsky), p. 131–139, Plenum Press, New York (1978).

    Google Scholar 

  4. D. E. Kipp, L. Adorini, S. Hill, A. Miller and E. E. Sercarz, Partial overlap of Ir gene-controlled responses to two proteins of limited relatedness: hen egg-white lysozyme and human lysozyme, Ann. Immunol. 131: 311–325 (1980).

    Google Scholar 

  5. J. Klein, Genetic control of immune response, in:“Biology of the mouse histocompatibility-2 complex,” p.411–448, Springer-Verlag, New York (1975).

    Google Scholar 

  6. L. B. Peterson, G. D. Wilner and D. W. Thomas, Murine T lymphocyte proliferative responses to human fibrinopeptide B, Fed. Proc. 39:1127 (1980).

    Google Scholar 

  7. M. E. Katz, R. M. Maizels, B. A. Araneo, A. Miller and E. E. Sercarz, The MHC regulates different specificity restrictions in the T cell proliferative response of mice to the lysozymes, Fed. Proc. 39:1127 (1980).

    Google Scholar 

  8. D. Hansburg, C. Hannum, J. K. Inman, E. Appella, E. Margoliash and R. H. Schwartz, Parallel cross-reactivity pattern of 2 sets of antigenically distinct cytochrome c peptides: possible evidence for a presentational model of Ir gene function, J. Immunol. 127:1844–1851 (1981).

    PubMed  CAS  Google Scholar 

  9. E. Heber-Katz, R. K. Schwartz, L. A. Matis, C. Hannum, T. Fairwell, E. Appella and D. Hansburg, The contribution of antigen-presenting cell MHC-gene products to the specificity of antigen-induced T cell activation, J. Exp. Med. 155:1086 (1982).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Miller, A. (1983). The Sorting-Out Problem in Antigen Presentation. In: Celada, F., Schumaker, V.N., Sercarz, E.E. (eds) Protein Conformation as an Immunological Signal. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3778-2_36

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3778-2_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3780-5

  • Online ISBN: 978-1-4613-3778-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics