Abstract
From the results described previously, it became evident that many, and perhaps all, carcinogens become covalently bound to nucleic acids in the target tissue. It also appears that this interaction is critical to the carcinogenic process. This covalent modification can introduce important changes, not only in the primary structure of nucleic acids, but also in the conformation (three-dimensional structure) of the nucleic acids at the sites of modification. Since distortions in nucleic acid structure are likely to have functional consequences, a detailed description of these conformational changes seems essential if we are to ultimately understand the carcinogenic process at the molecular level.
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© 1983 Plenum Press, New York
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Singer, B., Grunberger, D. (1983). Conformation of DNA Modified by Bulky Aromatic Carcinogens. In: Molecular Biology of Mutagens and Carcinogens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3772-0_7
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DOI: https://doi.org/10.1007/978-1-4613-3772-0_7
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