Abstract
The chemical combination of pharmacologically active compounds with polymers is currently receiving considerable attention. Objectives are to improve the duration of activity, to obtain a more cell-specific uptake or to reduce the toxicity of the parent drug1,2,3 Macromolecular derivatives of a drug can be obtained either by converting the drug into a reactive derivative that can be polymerized or by binding the drug onto an existing natural or synthetic polymer.
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References
S.W. Kim, R.V. Petersen and J. Feyen, “Drug Design,” Academic Press, New York, 1980, pg. 193.
H.G. Batz, Adv. in Polymer Sei., 23, 26 (1971).
H. Ringsdorf, J. Polymer Sei., Symp. 51, 135 (1975).
L. Molteni, “Drug Carriers in Biologie and Medicine” (G. Gregoriadis, Ed.), Academic Press, New York, 1979, Chpt. 6.
M.I. Shtil’man, Russ. Chem. Rev., 48, 11 (1979).
A.D. Virnik, K.P. Khomyakov and I.F. Skokova, Russ. Chem. Rev., 44(7), 588 (1975).
A. Jeanes, W.C. Haynes, C.A. William, I.C. Rankin, E.H. Melvin, M.J. Austin, J.E. Cluskey, B.E. Fisher, H.N. Tsuchiya and C.E. Rist, J. Am. Chem. Soc., 76, 5041 (1954).
K.P. Khomyakov, M.A. Penenzhik, A.D. Virnik and Z.A. Rogovin, Vysokomol. Soyed., 7(6), 1030 (1965).
B. Lindberg and S. Svensson, Acta Chem. Scand., 22, 1907 (1968).
E. Pacsu, Text. Res. J., 16, 105 (1956).
Z.A. Rogovin, A.D. Virnik, K.P. Khomyakov, O.P. Laletina and M.A. Penenzhik, J. Macromol. Sei.-Chem., A6(3), 569 (1972).
M.F. Ishak and T. Painter, Acta Chem. Scand., 25, 3875 (1971).
T. Painter and B. Larsen, Acta Chem. Scand., 24, 813 (1970).
T. Painter and B. Larsen, Acta Chem. Scand., 24, 2366 (1970).
T. Painter and B. Larsen, Acta Chem. Scand., 27, 1957 (1973).
K.P. Khomyakov, A.D. Virnik, S.N. Ushakov and Z.A. Rogovin, Vysokomol. Soyed., 7(6), 1035 (1965).
L.S. Levitt, J. Org. Chem., 20, 1297 (1955).
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© 1983 Plenum Press, New York
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Schacht, E., Ruys, L., Vermeersch, J., Goethals, E. (1983). Modified Polysaccharides with Potential Anti-Arrhythmic Activity. In: Carraher, C.E., Moore, J.A. (eds) Modification of Polymers. Polymer Science and Technology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3748-5_22
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DOI: https://doi.org/10.1007/978-1-4613-3748-5_22
Publisher Name: Springer, Boston, MA
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