Abstract
The successful screening of large populations of somatic cells for the presence of cells of mutant phenotype has been the goal of several investigations [1–9]. A system for detecting somatic-cell mutants would serve many valuable ends. In addition to its utility in estimating the genetic risks to subjects exposed to mutagenic agents, the system would constitute a means for investigation of various aspects of somatic-cell biology in man, including the testing of models of proliferation and renewal of pluripotent and committed stem-cell pools [8]. We have been attempting to develop a system for the detection of rare erythrocytes that contain abnormal hemoglobins as a consequence of somatic-cell mutation. Our purpose in this paper is to summarize our efforts to date and to outline certain possibilities for further research that derive from the availability of monoclonal antibodies specific for particular globin chains.
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© 1983 Plenum Press, New York
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Stamatoyannopoulos, G., Nute, P.E. (1983). Detection of Somatic Mutants of Hemoglobin. In: de Serres, F.J., Sheridan, W. (eds) Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Environmental Science Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3739-3_3
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DOI: https://doi.org/10.1007/978-1-4613-3739-3_3
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