Some Research Needs to Support Mutagenicity Risk Assessments from Whole Mammal Studies
The primary goal of regulatory agencies concerned with human health is to ensure that exposure to chemical substances does not present unreasonable risks. This involves assessing the potential of chemical substances to cause toxic effects and weighing these effects against cost and benefit considerations. If the toxicity and exposure data allow, attempts are made to estimate health damage to the human population. For most environmental chemicals, human data are unavailable. On those occasions when chemical exposure can be associated with a toxicological response in humans, many people have already been exposed and irreparable damage may have occurred. Examples of such events include the kepone incident, neurological disorders; the dibromochloropropane incident, sterility; and the vinyl chloride incident, liver angiosarcomas. Therefore, it is imperative that animal toxicity studies be conducted to assess the likely human health risk before such effects are observed.
KeywordsSister Chromatid Exchange Mouse Test Mammal Study IARC Monograph Ethyl Nitrosourea
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