Abstract
In extrapolating animal data to humans, in order to attempt to estimate genetic hazards, there are several separate types of extrapolation which have to be made (1) from experimental to environmental dose levels, (2) from one cell type to another, e.g., from somatic to germ cells, or from male to female germ cells, (3) from one species to another, and (4) from estimated mutation rates to cases of genetic disease in man.
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Lyon, M.F. (1983). Problems in Extrapolation of Animal Data to Humans. In: de Serres, F.J., Sheridan, W. (eds) Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Environmental Science Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3739-3_19
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DOI: https://doi.org/10.1007/978-1-4613-3739-3_19
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