Abstract
The remarkable complexities of eukaryotic gene organization and gene expression have received much emphasis in recent years. Whereas the organizational characteristics of polycistronic operons in E. coli are fairly well understood and appear quite straight forward, those of eukaryotes are considerably more complex as exemplified particularly by the analysis of the β-globin gene of the mouse. The specific substructure of the mammalian gene including coding sequencies transcribed into mRNA (exons) as well as non-coding intervening sequencies (introns), in contrast to the uninterrupted continuity of coding sequences in bacterial genes allows for various levels of control and has altered significantly the concept of the eukaryotic gene, as well as its organization and expression. This should also have an impact on approaches to the study of specific locus mutations which may include effects on all elements of the gene complex, not only on those containing the coding sequences.
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© 1983 Plenum Press, New York
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Gluecksohn-Waelsch, S. (1983). Developmental Genetics of Specific Locus Mutations. In: de Serres, F.J., Sheridan, W. (eds) Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Environmental Science Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3739-3_16
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DOI: https://doi.org/10.1007/978-1-4613-3739-3_16
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