Abstract
Mutations scored in specific-locus experiments can serve many purposes. Their primary function, of course, is to detect and measure mutagenicity of an agent [1]. This primary function is fulfilled rapidly and accurately, thanks to the well-defined phenotypes of mutations at the marked loci. However, when resources permit the setting up of stocks and the subsequent genetic analysis of the mutations, the information obtained can make major contributions to several other areas of knowledge. Such information can shed light on the nature of mutations induced by specific agents, and on the manner in which certain types of genetic lesions are expressed on the organismic level. These areas of information are needed, in combination with each other, for an assessment of risk. Thirdly, the findings shed light on the genetic organization in mammalian chromosomes. Finally, they serve to identify tools for further investigations in basic genetics and mutagenesis. This paper summarizes contributions to these areas from findings made on mutations induced in radiation experiments at Oak Ridge.
Research sponsored by the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation
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L. B. Russell, P. B. Selby, E. von Halle, W. Sheridan, and L. Valcovic, The mouse specific-locus test with agents other than radiation: Interpretation of data and recommendations for future work, Mutation Res., 86:329–354 (1981).
W. L. Russell, X-ray-induced mutations in mice, Cold Spring Harbor Symposia on Quant. Biol., 16:327–336 (1951).
L. B. Russell and W. L. Russell, Genetic analysis of induced deletions and of spontaneous nondisjunction involving chromosome 2 of the mouse, J. Cellular Comp. Physiol., 56, Suppl. 1, 169–188 (1960).
L. B. Russell, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations, Mutation Res., 11:107–123 (1971).
L. B. Russell, W. L. Russell, and E. M. Kelly, Analysis of the albino-locus region of the mouse, I. Origin and viability, Genetics, 91:127–139 (1979).
L. B. Russell, Analysis of the albin-locus region of the mouse, II. Fractional mutants, Genetics, 91:141–147 (1979).
L. B. Russell and G. D. Raymer, Analysis of the albino-locus region of the mouse, III. Time of death of prenatal lethals, Genetics, 92:205–213 (1979).
L. B. Russell, C. S. Montgomery, and G. D. Raymer, Analysis of the albino-locus region of the mouse: IV. Characterization of 34 deficiencies, Genetics, 100:427–453 (1982).
S. Gluecksohn-Waelsch, Genetic control of morphogenetic and biochemical differentiation: lethal albino deletions in the mouse, Cell, 16:225–237 (1979).
L. B. Russell, Mammalian X-chromosome action: inactivation limited in spread and in region of origin, Science, 140:976–978 (1963).
L. B. Russell and C. S. Montgomery, Comparative studies on X-autosome translocations in the mouse, II. Inactivation of autosomal loci, segregation, and mapping of autosomal breakpoints in five T(X;1)’s, Genetics, 64:281–312 (1970).
L. B. Russell and N. L. A. Cacheiro, The use of mouse X-autosome translocations in the study of X-inactivation pathways and nonrandomness, in: “Genetic Mosaics and Chimeras in Mammals,” Liane B. Russell, ed., pp. 393–416, Plenum Press, New York (1978).
L. B. Russell, W. L. Russell, R. A. Popp, C. Vaughan, and K. B. Jacobson, Radiation-induced mutations at the mouse hemoglobin loci, Proc. Natl. Acad. Sci. USA, 73:2843–2846 (1976).
L. B. Russell, W. L. Russell, K. B. Jacobson, R. A. Popp, and C. Vaughan, Induced mutations at the mouse hemoglobin loci, Genetics, 83:s65 (1976).
L. B. Russell, unpublished.
A. Chovnick, V. Finnerty, A. Schalet, and P. Duck., Studies on genetic organization in higher organisms: Analysis of a complex gene in Drosophila melanogaster, Genetics, 62:145–160 (1969).
D. A. Miller, V. G. Dev, R. Tantravahi, O. J. Miller, M. B. Schiffman, R. A. Yates, and S. Glueckshon-Waelsch, Cytological detection of the c 25H deletion involving the albino (c) locus on chromosome 7 in the mouse, Genetics, 78:905–910 (1974).
L. B. Russell and N. L. A. Cacheiro, The c-locus region of the mouse; genetic and cytological studies of small and intermediate deficiencies, Genetics, 86:s53–s54 (1977).
N. L. A. Cacheiro and L. B. Russell, unpublished.
W. Sheridan, The detection of induced recessive lethal mutations in mice, these proceedings (1982).
T. H. Roderick, Utilization of inversions to detect and localize recessive lethal mutations, these proceedings (1982).
D. L. DeHamer, A biochemical study of lethal mutations at the c-locus in the mouse, Ph.D. Dissertation, The University of Tennessee (1975).
S. Gluecksohn-Waelsch, M. B. Schiffman, J. Thorndike, and C. F. Cori, Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase, Proc. Natl. Acad. Sci. USA, 71:825–829 (1974).
E. G. Bernstine, L. B. Russell, and C. S. Cain, Effect of gene dosage on expression of mitochondrial malic enzyme activity in the mouse, Nature, 271:748–750 (1978).
L. B. Russell, Genetic and functional mosaicism in the mouse, in: “The Role of Chromosomes in Development,” Michael Locke, ed., pp. 153–181, Academic Press, New York (1964).
L. B. Russell, J. W. Bangham, and C. S. Montgomery, The use of X-autosome translocations in the mouse for the study of properties of autosomal genes, Genetics, 50:281–282 (1964).
L. B. Russell and E. G. Bernstine, Mammalian mutagenesis: future directions, in: “Molecular and Cellular Mechanisms of Mutagenesis,” J. F. Lemontt and W. M. Generoso, eds., pp. 345–360, Plenum Press, New York (1982).
W. L. Russell, L. B. Russell, and E. M. Kelly, Radiation dose rate and mutation frequency, Science, 128:1546–1550 (1958).
W. L. Russell, Factors affecting mutagenicity of ethylnitrosourea in the mouse specific-locus test and their bearing on risk estimation, in: “Environmental Mutagens and Carcinogens,” Sugimura, Kondo, and Takebe, eds., pp. 59–70, Tokyo Press, Tokyo, and Alan R. Liss, Inc., New York (1982).
E. G. Bernstine, C. Koh, and C. C. Lovelace, Regulation of mitochondrial malic enzyme synthesis in mouse brain, Proc. Natl. Acad. Sci. USA, 76:6539–6541 (1979).
L. B. Russell, Order of d, se, sv, Mouse News Letter, 38:32 (1968).
L. B. Russell, N. L. A. Cacheiro, and C. S. Montgomery, Attempts at genetic “rescue” of male sterility resulting from X-autosome translocations, Genetics, 94:s89-s90 (1980).
L. Albritton and E. G. Bernstine, unpublished.
L. B. Russell, Heterozygous effects on viability of d or se mutations that involve a known minimum number of lethal functional units, Oak Ridge National Laboratory Biology Division Annual Prog. Rept., ORNL-4817, pp. 114–116 (1972).
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Russell, L.B. (1983). Qualitative Analysis of Mouse Specific-Locus Mutations: Information on Genetic Organization, Gene Expression, and the Chromosomal Nature of Induced Lesions. In: de Serres, F.J., Sheridan, W. (eds) Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Environmental Science Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3739-3_15
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DOI: https://doi.org/10.1007/978-1-4613-3739-3_15
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