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Mutational Analysis in Cultured Human-Hamster Hybrid Cells

  • Chapter
Chemical Mutagens

Abstract

A convincing body of evidence has now accrued that a large proportion of human developmental disease, including cancer, is caused by environmental agents acting directly or after metabolic activation to produce damage in the genome of affected somatic cells. (1−6) This concept has led to attempts to develop short-term in vitro tests that will provide reliable and scientifically sound means of assessing the mutagenic and carcinogenic potential of environmental agents so as to reduce harmful exposure to humans.

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Authors and Affiliations

  1. Eleanor Roosevelt Institute for Cancer Research, Inc., and Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA

    C. A. Waldren

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  1. C. A. Waldren
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Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

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© 1983 Plenum Press, New York

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Waldren, C.A. (1983). Mutational Analysis in Cultured Human-Hamster Hybrid Cells. In: de Serres, F.J. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3694-5_8

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  • DOI: https://doi.org/10.1007/978-1-4613-3694-5_8

  • Publisher Name: Springer, Boston, MA

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