Chemically Induced Changes in Sperm in Animals and Humans

  • John C. Topham


Semen assays provide effective methods for the evaluation of induced damage to mammalian germ cells. Increases in the number of abnormally shaped sperm or decreases in sperm count or motility are associated with reduced fertility in humans and animals. In 1978, Wyrobek and Bruce(1) reviewed the methods and results obtained with the F0 sperm head morphology assay in mice, discussed some examples of chemicals that induced abnormal sperm morphology in humans, and described the rationale for both the F0 and F1 sperm head morphology assays in mice.


Sperm Count Lead Acetate Human Sperm Semen Quality Sperm Head 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John C. Topham
    • 1
  1. 1.Pharmaceuticals Division, Safety of MedicinesImperial Chemical Industries PLCMacclesfield, CheshireUK

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