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The Use of Disulfiram and Other Alcohol-Sensitizing Drugs in the Treatment of Alcoholism

  • John E. Peachey
  • Claudio A. Naranjo
Part of the Research Advances in Alcohol and Drug Problems book series (AADP, volume 7)

Abstract

The alcohol-sensitizing drugs are used with the expectation of deterring alcoholics from further drinking. Even though many drugs are available, only disulfiram (tetraethylthiuram disulfide®, Antabuse, Abstinyl®) and possibly calcium carbimide (citrated calcium carbimide, Temposil®, Abstem®) have current therapeutic applications in primary* alcoholics (Sellers et al., 1981). Disulfiram is available in many countries, whereas calcium carbimide is prescribed less frequently and is not available in the United States. Notwithstanding the many claims for the effectiveness of these drugs, their continued use in alcoholism treatment has been questioned (Fried, 1977) because of reports of drug-induced toxicity (Peachey et al., 1981a) and lack of experimental evidence that they are efficacious in exerting a positive treatment outcome (Mottin, 1973; Naranjo, 1983).

Keywords

Carbon Disulfide Aldehyde Oxidase Alcoholism Treatment Adverse Drug Reaction Probability Scale Thiuram Disulfide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amit, Z., Levitan, D. E., Brown, Z. E., and Sutherland, E. A., 1977, Catecholaminergic involvement in alcohol's rewarding properties: Implications of a treatment model for alcoholics, in: Advances in Exp. Med. Bioi., 85A, Alcohol Intoxication and Withdrawal IlIa, BiologicalAspects. of Ethanol ( M. M. Gross, ed.), pp. 48 - 94, Plenum Press, New York.Google Scholar
  2. Anvaer, S. I., Andreeva, V. S., Zak, N. N., and Morozov, V. M., 1952, On the treatment of chronic alcoholism with thiuram, Zh. Nevropatol. Psikhiatr. 52 :58.Google Scholar
  3. Anzil, A. P., and Dozic, S., 1978, Disulfiram neuropathy: An experimental study in the rat, J. bNeuropathol. Exp. Neurol. 37 :585.Google Scholar
  4. Armstrong, J. D., and Kerr, H. T., 1956, A new drug for alcoholism treatment. II. A new protective drug in the treatment of alcoholism (preliminary clinical trial of citrated calcium carbimide), Can. Med. Assoc. J. 74 :795.Google Scholar
  5. Baekeland, F., 1977, Evaluation of treatment methods in chronic alcoholism, in: The Biology of Alcoholism, Treatment and Rehabilitation of Chronic Alcoholics ( B. Kissin and H. Begleiter, eds.), pp. 385–440, Plenum Press, New York.Google Scholar
  6. Baekeland, F., and Lundwall, L., 1975, Dropping out of treatment: A critical review, Psychol. Bull. 82 :738.Google Scholar
  7. Baekeland, F., Lundwall, L., Kissin, B., and Shanahan, T., 1971, Correlates of outcome in disulfiram treatment of alcoholism, J. Nerv. Ment. Dis. 153 :1.Google Scholar
  8. Bell, R. G., 1956, A new drug for alcoholism treatment. III. Clinical trial of citrated calcium carbimide, Can. Med. Assoc. J. 74 :797.Google Scholar
  9. Benitz, K. F., Kramer, A. W. Jr., and Dambach, G., 1965, Comparative studies on the morphologic effects of calcium carbimide, propylthiouracil and disulfiram in male rats, Toxicol. Appl. Pharmacol. 7 :128.Google Scholar
  10. Benowitz, N., Rogers, W., and Wilson, M., 1978, Disulfiram induced hypertension in normal man, Clin. Res. 26: 99A.Google Scholar
  11. Bigelow, G., Strickler, D., Leibson, I., and Griffiths, R., 1976, Maintaining disulfiram ingestion among outpatient alcoholics: A security-deposit contingency contracting procedure, Behav. Res. Ther. 14: 378.Google Scholar
  12. Blackwell, B., 1972, The drug defaulter, Clin. Pharmacol. Ther. 13 :841.Google Scholar
  13. Blackwell, B., 1973, Drug therapy-patient compliance, N. Engl. J. Med. 289 :249.Google Scholar
  14. Boss, D., Sauter, A., and Cornu, F., 1976, Abstinenzverhalten und disulfiram-plasma konzentration bei ackoholiken nach Esperal-implantation, Schweiz. Med. Wochenschur. 106 :1074.Google Scholar
  15. Bradley, W. G., and Hewer, R. L., 1966, Peripheral neuropathy due to disulfiram, Br. Med. J. 2: 449.Google Scholar
  16. Brien, J. F., and Loomis, C. W., 1983, Pharmacokinetics of disulfiram and calcium carbimide, in: Alcohol-Sensitizing Drugs: Current Status in Alcoholism Treatment (1. E. Peachey and 1. F. Brien, eds.), Addiction Research Foundation, Toronto.Google Scholar
  17. Brien, J. F., Peachey, J. E., Rogers, B. J., and Loomis, C. W., 1978, A study of the calcium carbimide-ethanol interaction in man, Eur. J. Clin. Pharmacol. 14 :133.Google Scholar
  18. Brien, J. F., Peachey, J. E., Loomis, C. W., and Rogers, B. J., 1979, The calcium carbimide-ethanol interaction: Effects of ethanol dose, Clin. Pharmacol. Ther. 25 :454.Google Scholar
  19. Brien, J. F., Peachey, J. E., and Loomis, C. W., 1980a, Intraindividual variability in the calcium carbimide-ethanol interaction, Eur. J. Clin. Pharmacol. 18 :199.Google Scholar
  20. Brien, J. F., Peachey, J. E., and Loomis, C. W., 1980b, Calcium carbimide-ethanol interaction, Clin. Pharmacol. Ther. 27 :426.Google Scholar
  21. Brunner-Orne, M., 1962, Evaluation of calcium carbimide in the treatment of alcoholism, J. Neuropsychiatry 3: 163.Google Scholar
  22. Busse, S., Mulloy, C. T., and Weisse, C. E., 1978, Disulfiram in the treatment of alcoholism: An Annotated Bibliography of the Addiction Research Foundation of Ontario, Canada.Google Scholar
  23. Busto, U., Naranjo, C. A., and Sellers, E. M., 1982, Comparison of two recently published algorithms to assess the probability of adverse drug reactions, Br. J. Clin. Pharmacol. 13 :223.Google Scholar
  24. Chevens, L. C. F., 1953, Antabuse addiction, Br. Med. J. 1 ;1450.Google Scholar
  25. Cobby J., Mayersohn, M., and Selliah, S., 1977, The rapid reduction of disulfiram in blood and plasma, J. Pharmacol. Exper. Ther. 202 :724.Google Scholar
  26. Collins, J. M., and Brown, L. M., 1960, Calcium carbimide-A new protective drug in alcoholism, Med. J. Aust. 1 :835.Google Scholar
  27. Cronkite, R. C., and Moos, R. H., 1978, Evaluating alcoholism treatment programs: An integrated approach, J. Consult. Clin. Psychol. 46 :1105.Google Scholar
  28. DeMaster, E., and Nagasawa, H. T., 1977, Disulfiram-induced acetonemia in rat and man, Res. Commun. Chem. Pathol. Pharmacol. 18 :361.Google Scholar
  29. De Saint Blanquat, G., Vidaillac, G., Lindenbaum, A., and Derache, R., 1976, Absorption digestive, fixation tissulaire et excretion du disulfirame administre oralement chez Ie rat, Arch. Intern. Pharmacodyn. Ther. 223 :339.Google Scholar
  30. Dietrich, R. A., and Erwin, V. G., 1971, Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate, Mol. Pharmacol. 7 :301.Google Scholar
  31. Dietrich, R. A., Troxell, P. A., Worth, W. S., and Erwin, V. G., 1976, Inhibition of aldehyde dehydrogenase in brain and liver by cyanamide, Biochem. Pharmacol. 25 :2733.Google Scholar
  32. Djuric, D., Postic-Grujin, A., Graovac-Leposavid, L., and Delic, V., 1973, Disulfiram as an indicator of human susceptibility to carbon disulfide. Excretion of diethyldithiocarbamate sodium in the urine of workers exposed to CS2 after oral administration of disulfiram, Arch. Environ. Health 26: 287.Google Scholar
  33. Dry, J., and Pradalier, A., 1973, Intoxication par la phenytoine au cours d une association therapeutique avec Ie disulfirame, Therapie 28: 799.Google Scholar
  34. Eisen, H. J., and Ginsberg, A. L., 1975, Disulfiram hepatotoxicity, Ann. Intern. Med. 83 :673.Google Scholar
  35. Eneanya, D. I., Bianchine, J. R., Duran, D. 0., and Andersen, B. D., 1981, The actions and metabolic fate of disulfiram, Ann. Rev. Pharmacol. Toxicol. 21 :575.Google Scholar
  36. Faiman, M. D., 1979, Biochemical pharmacology of disulfiram, in: Biochemistry and Pharmacology of Alcoholism Vol. 2 ( E. Majchrowicz and E. P. Noble, eds.), pp. 325–348, Plenum Press, New York.Google Scholar
  37. Faiman, M. D., Dodd, D. E., and Hanzlik, R. E., 1978a, Distribution of 35S disulfiram and metabolites in mice, and metabolism of 35S disulfiram in the dog, Res. Cammun. Chem. Pathal. Pharmacal. 21 :543.Google Scholar
  38. Faiman, M. D., Dodd, D. E., Minor, S. S., and Hanzlik, R., 1978b, Radioactive and non-radioactive methods for the in vivo determination of disulfiram, diethyldithiocarbamate, and diethyldithiocarbamate- methyl ester, Alcoholism: Clin. Exp. Res. 2 :366.Google Scholar
  39. Faiman, M. D., Artman, L., and Haga, K., 1980, Disulfiram distribution and elimination in the rat after oral and intraperitoneal administration, Alcoholism: Clin. Exp. Res. 4 :412.Google Scholar
  40. Fergusson, J. K. W., 1958, A new drug for alcoholism treatment. I. A new drug for the treatment of alcoholism, Can. Med. Assoc. J. 74 :793.Google Scholar
  41. Fox, R., 1958, Antabuse as an adjunct to psychotherapy in alcoholism, N.Y. State J. Med. 58 :1540.Google Scholar
  42. Fox, R., 1967, A multidisciplinary approach to the treatment of alcoholism, Am. J. Psychiatry 123: 769.Google Scholar
  43. Fox, R., 1968, Disulfiram-Alcohol side effects (letter), J. Am. Med. Assoc. 204 :179.Google Scholar
  44. Freundt, K. J., Lieberworth, K., Netz, H., and Pohlmann, E., 1976, Blood acetaldehyde in alcoholized rats and humans during inhalation of carbon disulphide vapour, Intern. Arch. Occup. Environ. Health 37 :35.Google Scholar
  45. Fried, R., 1977, Comments on antabuse therapy in alcoholism (letter), Alcoholism: Clin. Exp. Res. 1: 275.Google Scholar
  46. Fried, R., 1980, Biochemical actions of antialcoholic agents, Subst. Alcohol Misuse/Abuse 1 :5.Google Scholar
  47. Fuller, R. K., and Roth, H. P., 1979, Disulfiram treatment of alcoholism, Ann. Intern. Med. 90 :901.Google Scholar
  48. Fuller, R. K., and Williford, W.O., 1980, Life-table analysis of abstinence in a study evaluating the efficacy of disulfiram, Alcoholism: Clin. Exp. Res. 4 :298.Google Scholar
  49. Gardner-Thorpe, C., and Benjamin, S., 1971, Peripheral neuropathy after disulfiram administration, J. Neurol. Neurosurg. Psych. 34 :253.Google Scholar
  50. Glaser, F. B., 1980, Anybody got a match? Treatment research and the matching hypothesis, in: Alcoholism Treatment in Transition ( G. Edwards and M. Grant, eds.), pp. 178–196, Croom Helm, London.Google Scholar
  51. Glatt, M. M., 1959, Disulfiram and citrated calcium carbimide in the treatment of alcoholism, J. Ment. Sci. 105 :476.Google Scholar
  52. Glud, J., 1949, The treatment of patients in Denmark with Antabuse; with suggestions for its trial in the United States, Q. J. Stud. Alcohol 10: 185.Google Scholar
  53. Goldstein, M., and Nakajima, K., 1967, The effect of disulfiram on catecholamine levels in the brain, J. Pharmacol. Exp. Ther. 157 :96.Google Scholar
  54. Goldstein, M., Anagnoste, B., Lauber, E., and McKereghan, M. R., 1964, Inhibition of dopamineJ3- hydroxylase by disulfiram, Life Sci. 3 :763.Google Scholar
  55. Goyer, P. F., and Major, L. F., 1979, Hepatotoxicity in disulfiram treated patients, J. Stud. Alcohol 40: 133.Google Scholar
  56. Gravelau, J., 1972, Les neuropathies peripheriques du disulfirame (Antabuse), Rev. Neurol. (Paris) 126: 149.Google Scholar
  57. Guarnaschelli, J. J., Zapanta, E., and Pitts, W., 1972, Intracranial hemorrhage associated with the disulfiram-alcohol reaction, Bull. Los Angeles Neurol. Soc. 37 :19.Google Scholar
  58. Hald, J., and Jacobsen, E., 1948, A drug sensitizing the organism to ethyl alcohol, Lancet 255 :1001.Google Scholar
  59. Haley, T. J., 1979, Disulfiram (tetraethylthioperoxydicarbonic diamide): A reappraisal of its toxicity and therapeutic application, Drug Metab. Rev. 9 :319.Google Scholar
  60. Hawkins, R. D., and Kalant, H., 1972, The metabolism of ethanol and its metabolic effects, Pharmacol. Rev. 24 :67.Google Scholar
  61. Hayman, M., 1966, Alcoholism: Mechanisms and Management, Charles and Thomas, Springfield, Illinois.Google Scholar
  62. Haynes, R. B., Taylor, D. W., and Sackett, D. L., 1979, Compliance in Health Care, Johns Hopkins Press, Baltimore.Google Scholar
  63. Heath, R. G., Nesselhof Jr., W., Bishop, M. P., and Byers, L. W., 1965, Behavioural and metabolic changes associated with administration oftetrethylthiuram disulfide (Antabuse), Dis. Nerv. Syst. 26: 99.Google Scholar
  64. Hoover, D. J., and Brien, J. F., 1980, Acetaldehyde concentration in rat blood and liver during the calcium carbimide-ethanol interaction, Res. Comm. Subst. Abuse 1:299.Google Scholar
  65. Hoover, D. J., and Brien, J. F., 1981, Acetaldehyde concentration in rat blood and brain during the calcium carbimide-ethanol interaction, Can. J. Physiol. Pharmacol. 59 :65.Google Scholar
  66. Hotson, J. R., and Langston, J. W., 1976, Disulfiram-induced encephalopathy, Arch. Neurol. 33: 141.Google Scholar
  67. Hunter, F. E. Jr., and Lowry, O. H., 1956, The effects of drugs on enzyme systems, Pharmacol. Rev. 8: 89.Google Scholar
  68. Hutchinson, T. A., Leventhal, J. M., Kramer, M. S., Karch, F. E., Lipman, A. G., and Feinstein, A. R., 1979, An algorithm for the operational assessment of adverse drug reactions. II. Demonstration of reproducibility and validity, J. Am. Med. Assoc. 242 :633.Google Scholar
  69. Iber, F. H., Dutta, S., Shamszad, M., and Krause, S., 1977, Excretion of radioactivity following the administration of 35S sulfur-labelled disulfiram in man, Alcoholism: Clin. Exp. Res. 1 :359.Google Scholar
  70. Jacobsen, E., 1952, Deaths of alcoholic patients treated with disulfiram (tetraethylthiuram disulfide) in Denmark, Q. J. Stud. Alcohol 13: 16.Google Scholar
  71. Jensen, J. C., and Faiman, M. D., 1980, Determination of disulfiram and metabolites from biological fluids by high-performance liquid chromatography, J. Chromatogr. 181: 407.Google Scholar
  72. Jones, R. W., and Helrich, A. R., 1972, Treatment of alcoholism in private practice. A national survey, Q. J. Stud. Alcohol 33: 117.Google Scholar
  73. Kasalder, J., 1963, Formation of S-glucuronide from tetraethylthiuram disulfide (Antabuse) in man, Biochim. Biophis. Acta 71 :730.Google Scholar
  74. Keefe, E. B., and Smith, F. W., 1974, Disulfiram hypersensitivity hepatitis, J. Am. Med. Assoc. 230: 435.Google Scholar
  75. Kiorboe, E., 1966, Phenytoin intoxication during treatment with Antabuse (disulfiram), Epilepsia 7: 246.Google Scholar
  76. Kissin, B., Platz, A., and Su, W. H., 1970, Social and psychological factors in the treatment of chronic alcoholism, J. Psychiat. Res. 8 :13.Google Scholar
  77. Kitson, T. M., 1977, The disulfiram-ethanol reaction, J. Stud. Alcohol 38: 96.Google Scholar
  78. Kitson, T. M., 1978, On the probability of implanted disulfiram s causing a reaction to ethanol, J. Stud. Alcohol 39 :183.Google Scholar
  79. Kitson, T. M., 1978, On the probability of implanted disulfiram s causing a reaction to ethanol, J. Stud. Alcohol 39 :183.Google Scholar
  80. Kitson, T. M., and Crow, K. E., 1979, Studies on possible mechanisms for the interaction between cyanamide and aldehyde dehydrogenase, Biochem. Pharmacol. 28 :2551.Google Scholar
  81. Kjeldguard, N. O., 1949, Inhibition of aldehyde oxidase from liver by tetraethylthiuram disulfide (Antabuse), Acta Pharmacol. Toxicol. 5: 397.Google Scholar
  82. Kline, S. A., and Kingstone, E., 1977, Disulfiram implants: The right treatment but the wrong drug? Can. Med. Assoc. J. 116 :1382.Google Scholar
  83. Kramer, M. S., Leventhal, J. M, Hutchinson, T. A., and Feinstein, A. R., 1979, An algorithm for the operational assessment of adverse drug reactions. I. Background, description, and instructions for use, J. Am. Med. Assoc. 242 :623.Google Scholar
  84. Kwentus, J., and Major, L. F., 1979, Disulfiram in the treatment of alcoholism. A review, J. Stud. Alcohol 40: 428.Google Scholar
  85. Lader, M. H., 1967, Alcohol reactions after single and multiple doses of calcium cyanamide, Q. J. Stud. Alcohol 38: 468.Google Scholar
  86. Lemere, F., 1953, Disulfiram as a sedative in alcoholism, Q. J. Stud. Alcohol 14: 197.Google Scholar
  87. Levy, M. S., Livingston, B. L.,and Collins, D. M., 1967, A clinical comparison of disulfiram and calcium carbimide, Am. J. Psychiat. 123: 1018.Google Scholar
  88. Li, T. K., 1977, Enzymology of human alcohol metabolism, Adv. Enzymol. 45 :427.Google Scholar
  89. Liebson, I., Bigelow, G., and Flamer, R., 1973, Alcoholism among methadone patients: A specific treatment method, Am. J. Psychiat. 130 :483.Google Scholar
  90. Lindros, K. 0., 1978, Acetaldehyde-its metabolism and role in the action of alcohol, in: Research Advances in Alcohol and Drug Problems Vol. 4 ( Y. Israel, F. B. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), pp. 111–176, Plenum Press, New York.Google Scholar
  91. Loiseau, P., Bracket, A., Henry, P., and Cenraud, P., 1975, Intoxication par la diphenylhydantoine lors d une cure de disulfirame, Presse Med. 4 :504.Google Scholar
  92. Loomis, C. W., and Brien, 1. F., 1981, Determination of carbimide in plasma by gas liquid chromatography, J. Chromatogr. 222 :421.Google Scholar
  93. Lovell, H. W., and Tintera, J. W., 1952, Alcoholism-recent advances in its treatment, Med. Times 80: 191.Google Scholar
  94. Lundwall, L., and Baekeland, F., 1971, Disulfiram treatment of alcoholism: A review, J. Nerv. Ment. Dis. 153 :381.Google Scholar
  95. McCabe, E. S., and Wilson, W. W., 1954, Dangerous cardiac effects of tetraethylthiuram disulfide (Antabuse) therapy in alcoholism, Arch. Intern. Med. 94:259.Google Scholar
  96. MacCallum, W. A. G., 1969, Drug interactions in alcoholism treatment (letter), Lancet 1 :313.Google Scholar
  97. McLachlan, J. F. C., 1972, Benefit from group therapy as a function of patient-therapist match on conceptual level, Psychother. Ther. Res. Pract. 9 :317.Google Scholar
  98. Macleod, S. M., Sellers, E. M., Giles, H. G., Billings, B. J., Martin, P. R., Greenblatt, D. J., and Marshman, J. A., 1978, Interactions of disulfiram with benzodiazepines, Clin. Pharmacol. Ther. 24 :583.Google Scholar
  99. Major, L. F., and Goyer, P. F., 1978, Effects of disulfiram and pyridoxine on serum cholesterol, Ann. Intern. Med. 88 :53.Google Scholar
  100. Major, L. F., Lerner, P., Ballenger, 1. C., Brown, G. L., Goodwin, F. K., and Lovenberg, W., 1979a, Dopamine-hydroxylase in the cerebrospinal fluid: Relationship to disulfiram-induced psychosis, Bioi. Psychiat. 14: 337.Google Scholar
  101. Major, L. F., Murphy, D. L., Gershon, E. S., and Brown, G. L., 1979b, The role of plasma amine oxidase, platelet monoamine oxidase, and red cell catechol-O-methyltransferase in severe behavioural reactions to disulfiram, Am. J. Psychiat. 136 :679.Google Scholar
  102. Marchner, H., and Tottmar, 0., 1978, A comparative study on the effects of disulfiram, cyanamide and l-aminocyclopropanol on the acetaldehyde metabolism in rats, Acta. Pharmacol. Toxicol. 43: 219.Google Scholar
  103. Marco, C. H., and Marco, J. M., 1980, Antabuse: Medication in exchange for a limited freedomis it legal?, Am. J. Law Med. 5 :295.Google Scholar
  104. Marconi, J., Solari, G., and Gaete, S., 1961, Comparative clinical study of the effects of disulfiram and calcium carbimide. II. Reaction to alcohol, Q. J. Stud. Alcohol 22 :46.Google Scholar
  105. Marie, C. A., 1955, A propos d'un nouveau mode de traitment de l alcoholisme chronique par implementation de disulfure de tetraethyl-thiourane (Thesis), University of Paris.Google Scholar
  106. Markham, J. D., and Hoff, E. C., 1953, Toxic manifestation in the Antabuse-alcohol reaction. Study of electrocardiographic changes, J. Am. Med. Assoc. 152 :1597.Google Scholar
  107. Marston, M. V., 1970, Compliance with medical regimens: A review of the literature, Nurs. Res. 19: 312.Google Scholar
  108. Martensen-Larsen, 0., 1948, Treatment of alcoholism with a sensitizing drug, Lancet 255 :1004.Google Scholar
  109. Matsuzaki, S., and Lieber, C. S., 1977, Increased susceptibility of hepatic mitochondrial to the toxicity of acetaldehyde after chronic ethanol consumption, Biochem. Biophy. Res. Comm. 75: 1059.Google Scholar
  110. Matteis, F., 1974, Covalent binding of sulfur to microsomes and loss of cytochrome P-450 during the oxidative desulfuration of several chemicals, Mol. Pharmacol. 10 :849.Google Scholar
  111. Mellor, C. S., and Sims, A. C. P., 1971, Citrated calcium carbimide-alcohol reaction-its severity and effectiveness as a deterrent, Br. J. Addict. 66: 123.Google Scholar
  112. Miller, W. R., and Caddy, G. R., 1977, Abstinence and controlled drinking in the treatment of problem drinkings, J. Stud. Alcohol 38 :986.Google Scholar
  113. Minto, A., and Roberts, F. J., 1960, Temposil a new drug in the treatment of alcoholism, J. Ment. Sci. 106 :288.Google Scholar
  114. Moddel, G., Bilboa, J. M., Payne, D., Ashby, P., 1978, Disulfiram neuropathy, Arch. Neurol. 35: 658.Google Scholar
  115. Mottin, J. L., 1973, Drug-induced attenuation of alcohol consumption. A review and evaluation of claimed potential or current therapies, Q. J. Stud. Alcohol 34 :444.Google Scholar
  116. Musacchio, J. M., Goldstein, M., Anagnoste, B., Poch, G., and Kopin, T. J., 1966, Inhibition of dopamine-J3-hydroxylase by disulfiram in vivo, J. Pharmacol. Exp. Ther. 152 :56.Google Scholar
  117. Musacchio, J. M., Goldstein, M., Anagnoste, B., Poch, G., and Kopin, T. J., 1966, Inhibition of dopamine-J3-hydroxylase by disulfiram in vivo, J. Pharmacol. Exp. Ther. 152 :56.Google Scholar
  118. Naranjo, C. A., Busto, D., Sellers, E. M., Sandor, P., Ruiz, I., Roberts: E. A., Janecek, E., Domecq, C., and Greenblatt, D. J., 1981a, A method for estimating the probability of adverse drug reactions, Clin. Pharmacol. Ther. 30 :239.Google Scholar
  119. Naranjo, C. A., Cappell, H., and Sellers, E. M., 1981b, Pharmacological control of alcohol consumption: Tactics for the identification and testing of new drugs, Addict. Behav. 6 :261.Google Scholar
  120. Nasrallah, H. A., 1979, Vulnerability to disulfiram psychosis, West. J. Med. 130 :575.Google Scholar
  121. Nora, A. N., Nora, J. J., and Blu, J., 1977, Limb reduction anomalies in infants born to disulfiramtreated alcoholic mothers (letter), Lancet 2 :664.Google Scholar
  122. Olesen, O. V., 1966, Disulfiram (Antabuse) as inhibitor of phenytoin metabolism, Acta. Pharmacol. Toxicol. 24 :317.Google Scholar
  123. Olesen, O. V., 1967, The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin, Arch. Neurol. 16 :642.Google Scholar
  124. O’Reilly, R. A., 1973, Interaction of sodium warfarin and disulfiram (Antabuse) in man, Ann. Intern. Med. 78 :73.Google Scholar
  125. Pattison, E. M., 1966, A critique of alcoholism treatment concepts with special reference to abstinence, Q. J. Stud. Alcohol 27 :49.Google Scholar
  126. Paulson, S. M., Krause, S., and Iber, F. L., 1977, Development and evaluation of a compliance test for patients taking disulfiram, Johns Hopkins Med. J. 141: 119.Google Scholar
  127. Peachey, J. E., 1981, Review of the clinical use of disulfiram and calcium carbimide in alcoholism treatment, J. Clin. Psychopharmacol. 1 :368.Google Scholar
  128. Peachey, J. E., Brien, J. F., Loomis, C. W., and Rogers, B. J., 1980, A study of calcium carbimide-ethanol interaction in man: Symptom response, Alcoholism: Clin. Exp. Res. 4 :322.Google Scholar
  129. Peachey, J. E., Brien, J. F., Roach, C. A., and Loomis, C. W., 1981a, A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide, J. Clin. Psychopharmacol. 1 :21.Google Scholar
  130. Peachey J. E., Zilm, D., Cappell, H., and Robinson, G., 1981b, Comparative study of the disulfiram- ethanol reaction and the carbimide-ethanol reaction in non-alcoholic men. I. Effects of initial alcohol exposure, Clin. Pharmacol. Ther. 29 :271.Google Scholar
  131. Peachey, J. E., Brien, J. F., Zilm, D. H., Loomis, C. W., Hemy, M. F., and Maglana S. M., 1981c, The calcium cyanamide-ethanol interaction in man. Effects of repeated ethanol administration, J. Stud. Alcohol 42: 208.Google Scholar
  132. Peachey, J. E., Zilm, D., and Cappell, H., 1981d, Comparative study of the disulfiram—ethanol reaction and the carbimide-ethanol reaction in non-alcoholic men. II. Effects of repeated drinks, Clin. Pharmacol. Ther. 29 :271.Google Scholar
  133. Peachey, J. E., Zilm, D. H., and Cappell, H., 1981e, Burning off the Antabuse: Fact or fiction?, Lancet 1 :943.Google Scholar
  134. Peachey, J. E., Maglana, S., Robinson, G. M., Hemy, M., and Brien, J. F., 1981!, Cardiovascular changes during the calcium carbimide-ethanol interaction, Clin. Pharmacol. Ther. 29 :40.Google Scholar
  135. Price, T. R., and Silberfarb, P. M., 1976, Convulsions following disulfiram treatment, Am. J. Psychiat. 133 :235.Google Scholar
  136. Rachman, S., and Teasdale, J., 1969, Aversion Therapy and Behaviour Disorders, An Analysis, pp. 14 - 29, Chaucer Press, London.Google Scholar
  137. Rainey, Jr., J. M., 1977, Disulfiram toxicity and carbon disulfide poisoning, Am. J. Psychiat. 134: 371.Google Scholar
  138. Ranek, L., and Andreasen, P. B., 1977, Disulfiram hepatotoxicity, Br. Med. J. 2 :94.Google Scholar
  139. Reilly T. M., 1976, Peripheral neuropathy associated with citrated calcium carbimide, Lancet 1 :911.Google Scholar
  140. Rothstein, E., 1968, Warfarin effect enhanced by disulfiram (letter), J. Am. Med. Assoc. 206 :1574.Google Scholar
  141. Rothstein, E., 1972, Rifampin with disulfiram (letter), J. Am. Med. Assoc. 219:1216.Google Scholar
  142. Musacchio, J. M., Goldstein, M., Anagnoste, B., Poch, G., and Kopin, T. J., 1966, Inhibition of dopamine-J3-hydroxylase by disulfiram in vivo, J. Pharmacol. Exp. Ther. 152 :56.Google Scholar
  143. Musacchio, J. M., Goldstein, M., Anagnoste, B., Poch, G., and Kopin, T. J., 1966, Inhibition of dopamine-J3-hydroxylase by disulfiram in vivo, J. Pharmacol. Exp. Ther. 152 :56.Google Scholar
  144. Naranjo, C. A., Busto, D., Sellers, E. M., Sandor, P., Ruiz, I., Roberts: E. A., Janecek, E., Domecq, C., and Greenblatt, D. J., 1981a, A method for estimating the probability of adverse drug reactions, Clin. Pharmacol. Ther. 30 :239.Google Scholar
  145. Naranjo, C. A., Cappell, H., and Sellers, E. M., 1981b, Pharmacological control of alcohol consumption: Tactics for the identification and testing of new drugs, Addict. Behav. 6 :261.Google Scholar
  146. Nasrallah, H. A., 1979, Vulnerability to disulfiram psychosis, West. J. Med. 130 :575.Google Scholar
  147. Nora, A. N., Nora, J. J., and Blu, J., 1977, Limb reduction anomalies in infants born to disulfiramtreated alcoholic mothers (letter), Lancet 2 :664.Google Scholar
  148. Olesen, O. V., 1966, Disulfiram (Antabuse) as inhibitor of phenytoin metabolism, Acta. Pharmacol. Toxicol. 24 :317.Google Scholar
  149. Olesen, O. V., 1967, The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin, Arch. Neurol. 16 :642.Google Scholar
  150. O’Reilly, R. A., 1973, Interaction of sodium warfarin and disulfiram (Antabuse) in man, Ann. Intern. Med. 78 :73.Google Scholar
  151. Pattison, E. M., 1966, A critique of alcoholism treatment concepts with special reference to abstinence, Q. J. Stud. Alcohol 27 :49.Google Scholar
  152. Paulson, S. M., Krause, S., and Iber, F. L., 1977, Development and evaluation of a compliance test for patients taking disulfiram, Johns Hopkins Med. J. 141: 119.Google Scholar
  153. Peachey, J. E., 1981, Review of the clinical use of disulfiram and calcium carbimide in alcoholism treatment, J. Clin. Psychopharmacol. 1 :368.Google Scholar
  154. Peachey, J. E., Brien, J. F., Loomis, C. W., and Rogers, B. J., 1980, A study of calcium carbimide-ethanol interaction in man: Symptom response, Alcoholism: Clin. Exp. Res. 4 :322.Google Scholar
  155. Peachey, J. E., Brien, J. F., Roach, C. A., and Loomis, C. W., 1981a, A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide, J. Clin. Psychopharmacol. 1 :21.Google Scholar
  156. Peachey J. E., Zilm, D., Cappell, H., and Robinson, G., 1981b, Comparative study of the disulfiram- ethanol reaction and the carbimide-ethanol reaction in non-alcoholic men. I. Effects of initial alcohol exposure, Clin. Pharmacol. Ther. 29 :271.Google Scholar
  157. Peachey, J. E., Brien, J. F., Zilm, D. H., Loomis, C. W., Hemy, M. F., and Maglana S. M., 1981c, The calcium cyanamide-ethanol interaction in man. Effects of repeated ethanol administration, J. Stud. Alcohol 42: 208.Google Scholar
  158. Peachey, J. E., Zilm, D., and Cappell, H., 1981d, Comparative study of the disulfiram—ethanol reaction and the carbimide-ethanol reaction in non-alcoholic men. II. Effects of repeated drinks, Clin. Pharmacol. Ther. 29 :271.Google Scholar
  159. Peachey, J. E., Zilm, D. H., and Cappell, H., 1981e, Burning off the Antabuse: Fact or fiction?, Lancet 1 :943.Google Scholar
  160. Peachey, J. E., Maglana, S., Robinson, G. M., Hemy, M., and Brien, J. F., 1981!, Cardiovascular changes during the calcium carbimide-ethanol interaction, Clin. Pharmacol. Ther. 29 :40.Google Scholar
  161. Price, T. R., and Silberfarb, P. M., 1976, Convulsions following disulfiram treatment, Am. J. Psychiat. 133 :235.Google Scholar
  162. Rachman, S., and Teasdale, J., 1969, Aversion Therapy and Behaviour Disorders, An Analysis, pp. 14 - 29, Chaucer Press, London.Google Scholar
  163. Rainey, Jr., J. M., 1977, Disulfiram toxicity and carbon disulfide poisoning, Am. J. Psychiat. 134: 371.Google Scholar
  164. Ranek, L., and Andreasen, P. B., 1977, Disulfiram hepatotoxicity, Br. Med. J. 2:94.Google Scholar
  165. Reilly T. M., 1976, Peripheral neuropathy associated with citrated calcium carbimide, Lancet 1 :911.Google Scholar
  166. Rothstein, E., 1968, Warfarin effect enhanced by disulfiram (letter), J. Am. Med. Assoc. 206 :1574.Google Scholar
  167. Rothstein, E., 1972, Rifampin with disulfiram (letter), J. Am. Med. Assoc. 219:1216.Google Scholar
  168. Rotter, J. B., 1966, Generalized expectancies for internal versus external control of reinforcement, Psychol. Monogr. 1 :80.Google Scholar
  169. Rumore, T. P, and Shulman, B., 1954, Toxic reactions to Antabuse, N.Y. State J. Med. 54 :1660.Google Scholar
  170. Scher, J., 1968, Disulfiram-alcohol side effects, Reply to Dr. Fox (letter), J. Am. Med. Assoc. 204: 180.Google Scholar
  171. Sellers, E. M., and Kalant, H., 1978, Pharmacotherapy of acute and chronic alcoholism and alcohol withdrawal syndrome, in: Principles ofPsychopharmacology ( N. G. Clarke and J. del Guidice, eds.), pp. 721–740, Academic Press, New York.Google Scholar
  172. Sellers, E. M., Cappell, H. D., and Marshman, J. A., 1979, Compliance in the control of alcohol abuse, in: Compliance in Health ( R. B. Haynes, D. W. Taylor and D. L. Sackett, eds.), pp. 223–243, Johns Hopkins Press, Baltimore.Google Scholar
  173. Sellers, E. M., Giles, H. G., Greenblatt, D. J. and Naranjo, C. A., 1980, Differential effects on benzodiazepine disposition by disulfiram and ethanol, Arzneim. Forsch/Drug Res. 30 :882.Google Scholar
  174. Sellers, E. M., Naranjo, C. A., and Peachey, J. E., 1981, Drugs to decrease alcohol consumption, N. Engl. J. Med. 305 :1255.Google Scholar
  175. Seppallainen, A. M. and Haltia M., 1980, Carbon disulfide, in: Experimental and Clinical Neurotoxicology ( P. S. Spencer and H. H. Schaumberg, eds.), Williams and Wilkins, Baltimore, pp. 356–373.Google Scholar
  176. Skinner, H. A., 1980, Client-treatment matching and the anti-alcohol drugs, Substudy No. 1118, Addiction Research Foundation, Toronto.Google Scholar
  177. Smolik, J. A., 1969, A case of death after Antikol administration, in: Disulfiram in Treatment of Alcoholism (S. Busse, C. T. Mulloy and C. E. Weise, eds.), abstr. 512, Addiction Research Foundation, Toronto.Google Scholar
  178. Stripp, B., Greene, F. E., and Gillette, J. R., 1969, Disulfiram impairment of drug metabolism by rat liver microsomes, J. Pharmacol. Exp. Ther. 170 :347.Google Scholar
  179. Stromme, J. H., 1963, Methahemoglobin formation induced by thiols, Biochem. Pharmacol. 12: 937.Google Scholar
  180. Stromme, J. H., 1965, Interaction of disulfiram and diethyldithocarbamate with serum proteins studied by means of a gel-filtration technique, Biochem. Pharmacol. 14 :381.Google Scholar
  181. Svendsen, T., Kristensen, M., Hansen, J., and Skovsted, L., 1976, The influence of disulfiram on the half-life and metabolic clearance rate of diphenylhydantoin and tolbutamide in man, Eur. J. Clin. Pharmacol. 9 :439.Google Scholar
  182. Thimann, J., 1951, Review of new drug therapies in the treatment of alcoholism, N. Engl. J. Med. 244: 939.Google Scholar
  183. Tong, T. G., Benowitz, N. L., and Kreek, M. J., 1980, Methadone-disulfiram interaction during methadone maintenance, J. Clin. Pharmacol. 20 :506.Google Scholar
  184. Tottmar, 0., and Hellstrom, E., 1979, Blood pressure response to ethanol in relation of acetaldehyde levels and dopamine-hydroxylase activity in rats pretreated with disulfiram, cyanamide and coprine, Acta, Pharmacol. Toxicol. 45 :272.Google Scholar
  185. Vazquez, J. J., and Pardo-Mindan, J., 1979, Liver cell injury (bodies similar to Lafora's) in alcoholics treated with disulfiram (Antabuse), Histopathology (Oxf.) 3: 377.Google Scholar
  186. Vasquez, J. J., and Cervera, S., 1980, Cyanamide-induced liver injury in alcoholics, Lancet 1 :361.Google Scholar
  187. Vesell, E. S., Passananti, G. T., and Lee, C. H., 1971, Impairment of drug metabolism by disulfiram in man, Clin. Pharmacol. Ther. 12 :785.Google Scholar
  188. Wada, T., Tanaka, Z., Sakurada, T., Shimada, K., Sato, K., and Horigome, S., 1960, Citrated calcium carbimide in the treatment of alcoholism, Postgrad. Med. 28 :188.Google Scholar
  189. Watson, C. P., Ashby, P., and Bilbao, J. M., 1980, Disulfiram neuropathy, Can. Med. Assoc. J. 123: 123.Google Scholar
  190. Whittington, H. G., and Grey, L., 1969, Possible interaction between disulfiram and isoniazid, Amer. J. Psychiat. 125: 1752.Google Scholar
  191. Wilson, A., 1975, Disulfiram implantation in alcoholism treatment, J. Stud. Alcohol 36: 555.Google Scholar
  192. Wilson, A., Davidson, W. J., Blanchard, R., and White, J., 1978, Disulfiram implantation: A placebo-controlled trial with two year follow-up, J. Stud. Alcohol 39 :809.Google Scholar
  193. Wilson, A., Davidson, W. J., and Blanchard, R., 1980, Disulfiram implantation: A trial using placebo implants and two tyPes of controls, J. Stud. Alcohol 41: 429.Google Scholar
  194. Witkin, H. A., and Goodenough, D. R., 1977, Field dePendence and inteTPersonal behaviour, Psych. Bull. 84 :661.Google Scholar
  195. Zemaitis, M. A., and Greene, F. E., 1976, Impairment of hepatic microsomal drug metabolism in the rat during daily disulfiram administration, Biochem. Pharmacol. 25 :1355.Google Scholar
  196. Zuccarello, M., and Anzil, A. P., 1979, A localized model of eXPerimental neuropathy by topical application of disulfiram, Exp. Neural. 64 :699.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John E. Peachey
    • 1
  • Claudio A. Naranjo
    • 2
  1. 1.Behavioural Pharmacotherapy Program, Addiction Research Foundation Clinical Institute, and Departments of Pharmacology and PsychiatryUniversity of TorontoTorontoCanada
  2. 2.Clinical Pharmacology Program, Addiction Research Foundation Clinical Institute, and Departments of Pharmacology and MedicineUniversity of TorontoTorontoCanada

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