Abstract
Because of the positive correlation between mutagenicity and carcinogenicity, short-term tests for mutagenicity are used widely as initial screening tests for substances of potential carcinogenicity. The Ames test (Ames et al., 1975) quantitating the reversion of histidine-requiring Salmonella typhimurium auxotrophs to histidine-nonrequiring prototrophs, has been used in different laboratories to study chemical mixtures obtained through extraction of environmental pollutants. A wide data base obtained from the Ames test includes studies of urban air particles (Pitts et al., 1977), automobile exhaust (Huisingh et al., 1978; Ohnishi et al., 1980; Clark et al., 1981), and coal combustion products (Fisher et al., 1979; Clark and Hobbs, 1980). Ames test-directed chemical fractionation has been used as an approach to identify mutagens in complex environmental mixtures (Dutcher et al., 1981).
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© 1983 Plenum Press, New York
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Li, A.P., Brooks, A.L., Clark, C.R., Shimizu, R.W., Hanson, R.L., Dutcher, J.S. (1983). Mutagenicity Testing of Complex Environmental Mixtures with Chinese Hamster Ovary Cells. In: Waters, M.D., Sandhu, S.S., Lewtas, J., Claxton, L., Chernoff, N., Nesnow, S. (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III. Environmental Science Research, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3611-2_12
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DOI: https://doi.org/10.1007/978-1-4613-3611-2_12
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