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Significance of Cutaneous Lesions in the Symptomatology of Exposure to Dioxins and Other Chloracnegens

  • K. D. Crow
Part of the Environmental Science Research book series (ESRH, volume 26)

Abstract

After a brief review of the subject of chloracnegenic toxicity, this paper examines two proposals. Firstly that the acnegenic potential of all chloroacnegens correlates perfectly with their systemic toxicity and, secondly, that with almost no exceptions chloracne still appears to be the most sensitive marker of poisoning by chloracnegens in the human subject. It is as such a marker that it is of great importance. Various alternative markers are examined and rejected in favor of chloracne. It is, of course, emphasized that the failure of chloracne to appear after apparent poisoning rules out short and medium term effects but cannot entirely preclude the potential existence of long term low dose effects, although none have so far been proven statistically to exist in over 30 years of follow-up.

Keywords

Soft Tissue Sarcoma Systemic Toxicity Sebaceous Gland Cutaneous Lesion Squamous Metaplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • K. D. Crow
    • 1
  1. 1.Princess Margaret HospitalSwindon WiltshireUK

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