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In Vitro Toxicity Testing of Environmental Agents pp 487–497Cite as

In Vitro Approaches to Neurotoxicity-- A Physiologist’s Perspective

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Abstract

Many methods for screening potential neurotoxicants have been proposed, but few attempts have been made to compare their relative sensitivities. Thus, until more research is done, it will be necessary to explore the utility of a wide variety of methodological approaches. Among these is the neurophysiological approach, which can include recordings obtained from intact unanesthetized subjects as well as isolated neurons in vitro. It is not yet clear whether the in vivo or in vitro approach will ultimately be most appropriate as a short-term test. Based on existing data, the most sensitive and cost-effective neurophysiological test currently available is an in vivo one: the visual-evoked response. The EPA neurotoxicology program is in the process of comparing the relative sensitivity of this test to other neurophysiological and nonneurophysiological methodologies.

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Authors and Affiliations

  1. Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA

    Robert S. Dyer

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  1. Robert S. Dyer
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Editors and Affiliations

  1. Research Triangle Institute, Research Triangle Park, North Carolina, USA

    Alan R. Kolber , Robert S. DeWoskin  & Thomas J. Hughes ,  & 

  2. National Institute of Environmental Health Sciences (BRAP), Research Triangle Park, North Carolina, USA

    Thomas K. Wong

  3. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Lester D. Grant

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© 1983 Plenum Press, New York

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Dyer, R.S. (1983). In Vitro Approaches to Neurotoxicity-- A Physiologist’s Perspective. In: Kolber, A.R., Wong, T.K., Grant, L.D., DeWoskin, R.S., Hughes, T.J. (eds) In Vitro Toxicity Testing of Environmental Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3566-5_22

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  • DOI: https://doi.org/10.1007/978-1-4613-3566-5_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3568-9

  • Online ISBN: 978-1-4613-3566-5

  • eBook Packages: Springer Book Archive

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