Behavioral Assays in Environmental Toxicology

  • Bernard Weiss

Abstract

Behavioral toxicology treats the whole organism as an assay system. Certain features of such an approach are exceedingly resistant to simplification, and it is doubtful that we will ever have the luxury of something approaching in vitro testing in convenience and clarity. Three aspects of behavioral assessment are especially difficult to simplify in reasonable ways. Psychophysics is the discipline that allows us to determine sensory capacity. With animals, complex, lengthy procedures are often the only alternative by which to assess subtle questions of sensory dysfunction. Measures of aversiveness and attractiveness are also definable only by behavioral techniques, yet constitute critical data for environmental standards. Behavioral epidemiology is the most obvious enemy of simplification since it deals with how people feel and function.

Keywords

Fatigue Toxicity Microwave Mercury Ozone 

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References

  1. Bodis-Wollner, I., and S. P. Diamond, 1976. The measurement of spatial contrast sensitivity in cases of blurred vision associated with cerebral lesion. Brain, 99: 695–710.CrossRefGoogle Scholar
  2. Evans, H. L., R. H. Garman, and B. Weiss, 1977. Methylmercury: exposure duration and regional distribution as determinants of neurotoxicity in nonhuman primates. Toxicol. Appl. Pharmacol., 41: 15–33.CrossRefGoogle Scholar
  3. FASEB Select Committee on GRAS Substances, 1977. Evaluation of health aspects of GRAS food ingredients: lessons learned and questions unanswered. Federation Proceedings, 36: 2525–2562.Google Scholar
  4. Feingold, B. F., 1975. “Why Your Child Is Hyperactive.” Random House, New York.Google Scholar
  5. Feingold, B. F., 1973. “Introduction to Clinical Allergy.” Thomas, Springfield, Illinois.Google Scholar
  6. Hayreh, M. M. S., S. S. Hayreh, G. L. Baumbach, P. Cancilla, G. Martin-Amat, and T. R. Tephley, 1980. Ocular toxicity of methanol: An experimental study, pp. 35–53. In: “Neurotoxicity of the Visual System,” W. H. Merigan and B. Weiss (eds.). Raven Press, New York.Google Scholar
  7. Kety, S. S., 1956. Human cerebral blood flow and oxygen consumption as related to aging. Res. Publ. Assoc. Res. Nerv. Ment. Pis., 35: 31–45.Google Scholar
  8. Lafferman, J. A., and E. K. Silbergeld, 1979. Erythrosin B inhibits dopamine transport in rat caudate synaptosomes. Science, 205: 410–412.ADSCrossRefGoogle Scholar
  9. Lewey, F. H., 1941. Neurological, medical, and biochemical signs and symptoms indicating chronic industrial carbon disulphide absorption. Ann. Int. Med., 15: 869–883.Google Scholar
  10. Maurissen, J. P. J., and B. Weiss, 1980. Vibration sensitivity as an index of somatosensory function in monkeys and humans, pp. 767–774. In: “Experimental and Clinical Neurotoxicology,” P. S. Spencer and H. Schaumberg (eds.). Williams and Wilkins, Baltimore, Maryland.Google Scholar
  11. Merigan, W. H., and B. Weiss (eds.), 1980. Preface. In: “Neurotoxicity of the Visual System.” Raven Press, New York.Google Scholar
  12. Mountcastle, V. B., R. H. LaMotte, and G. Carli, 1972. Detection thresholds for stimuli in humans and monkeys: comparison with threshold events in mechanoreceptive afferent nerve fibers innervating the monkey hand. J. Neurophysiology, 35: 122–136.Google Scholar
  13. Needleman, H. L., C. Gunnoe, A. Leviton, R. Reed, H. Peresie, C. Maher, and P. Barrett, 1979. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. New Eng. J. Med., 300: 689–695.CrossRefGoogle Scholar
  14. Rice, D. C. and R. F. Willes, 1979. Neonatal low-level lead exposure in monkeys (Macaca fascicularis): effect on two-choice nonspatial form discrimination. J. Environ. Pathol. Toxicol., 2: 1195–1203.Google Scholar
  15. Rice, D. C., S. G. Gilbert, and R. F. Willes, 1979. Neonatal low- level lead exposure in monkeys: locomotor activity, schedule-controlled behavior, and the effects of amphetamine. Tox. Appl. Pharmacol., 51 (3): 503–513.CrossRefGoogle Scholar
  16. Shaywitz, B. A., J. R. Goldenring, and R. S. Wool, 1978. The effect of chronic administration of food colorings on activity levels and cognitive performance in normal and hyperactive developing rat pups. Ann. Neurol., 4: 196.Google Scholar
  17. Spyker, J. M., 1975. Behavioral teratology and toxicology, pp. 311–349. In: “Behavioral Toxicology,” B. Weiss and V. G. Laties (eds.). Plenum Press, New York.Google Scholar
  18. Stern, S., L. Margolin, B. Weiss, S.-T. Lu, and S. Michaelson, 1979. Microwaves affect thermoregulatory behavior in rats. Science, 206 (4423): 1198–1201.ADSCrossRefGoogle Scholar
  19. Valciukas, J. A., R. Lilis, H. Anderson, M. Wolff, and M. Petrocci, 1979. The neurotoxicity of polybrominated biphenyls: Results of a medical field survey. Ann. N.Y. Acad. Sci., 320: 337–367.ADSGoogle Scholar
  20. Weiss, B., 1978. The whole animal as an assay system, pp. 53–66. In: “Environmental Pollutants,” T. Y. Toribara, J. R. Coleman, B. E. Dahneke, and I. Feldman (eds.). Plenum Press, New York.CrossRefGoogle Scholar
  21. Weiss, B., and W. Simon, 1975. Quantitative perspectives on the long-term toxicity of methylmercury and similar poisons, pp. 429–435. In: “Behavioral Toxicology,” B. Weiss and V. G. Laties (eds.). Plenum Press, New York.Google Scholar
  22. Weiss, B., and V. G. Laties, 1961. Behavorial thermoregulation. Science, 133: 1338–1344.ADSCrossRefGoogle Scholar
  23. Weiss, B., C. Cox, M. Young, S. Margen, and J. H. Williams, 1979. Behavioral epidemiology of food additives. Neurobehavioral Toxicology, 1 (suppl.1): 149–155.Google Scholar
  24. Weiss, B., J. H. Williams, S. Margen, B. Abrams, B. Caan, L. J. Citron, C. Cox, J. McKibben, D. Ogar, and S. Schultz, 1980. Behavioral responses to artificial food colors. Science, 207: 1487–1489.ADSCrossRefGoogle Scholar
  25. Wood, R. W., 1979. Behavioral evaluation of sensory irritation evoked by Ammonia. Tox. Appl. Pharmacol., 50: 157–162.CrossRefGoogle Scholar
  26. Wood, R. W., J. Grubman, and B. Weiss, 1977. Nitrous oxide self-administration by the squirrel monkey, J. Pharmacol. Exp. Therap., 202: 491–499.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Bernard Weiss
    • 1
    • 2
  1. 1.Department of Radiation BiologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Biophysics and Environmental Health Sciences CenterUniversity of Rochester School of Medicine and DentistryRochesterUSA

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