Abstract
Diminished response of animals to ethanol after repeated exposure may be not only the result of adaptive changes at the site of ethanol action, but also the result of changes in the ethanol metabolism. The latter case, that is, metabolic tolerance, includes three major factors which may undergo adaptive changes: (1) rate of ethanol elimination and thus rate of acetaldehyde formation, (2) actions of ethanol-derived acetal-dehyde, and (3) ethanol-induced redox effects.
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Eriksson, C.J.P., Deitrich, R.A. (1983). Metabolic Mechanisms in Tolerance and Physical Dependence on Alcohol. In: Kissin, B., Begleiter, H. (eds) The Biology of Alcoholism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3518-4_8
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