Substance P in the Nervous System

  • T. M. Jessell


The properties of a vasodepressor substance extracted from brain and intestine and originally called preparation P were first described by von Euler and Gaddum in 1931. Fifty years later, it is certain that substance P must play an important role in nervous system function, yet it is surprisingly difficult to cite a single physiologically relevant action of substance P, supposedly the doyen of the common peptides (Pearse, 1978). In contrast, the physiological role of many other neuropeptides and releasing hormones that have been discovered more recently is now well established.


Dorsal Root Ganglion Sensory Neuron Dorsal Horn Dorsal Root Ganglion Neuron Primary Sensory Neuron 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • T. M. Jessell
    • 1
  1. 1.Department of PharmacologySt. George’s Hospital Medical SchoolLondonUK

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