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Micellar Effects on the Radiation Chemistry of Biologically Important Compounds

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Solution Behavior of Surfactants

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Abstract

Micellar effects on the steady state and pulse radiolytic studies of different biologically important compounds such as purine bases, Vitamin K, Folic acid, and radiosensitizers isoindole quinones have been investigated in order to establish a suitable model for biological systems. Rate constants of these biologically important compounds with the radiolytic species (·OH and e−aq) have been determined in the presence of micellar surfactants hexadecyltrimethyl ammonium bromide, sodium dodecyl sulfate and polyoxyethylene 15 nonylphenol. Using radiochromatographic and spectroscopic techniques,destruction yields of these biologically important compounds have been determined in the presence of micellar surfactants. The contributions of each of the radiolytic species (·OH, e−aq and H·) to the radiolytic decomposition of these biologically important compounds have been measured. Mechanisms for these radiation induced reactions will be proposed and compared with other biological systems investigated elsewhere. Potentialities of these micellar environments to the study of biological systems and their application in the radiotherapeutic treatment of cancerous tissues will be discussed.

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References

  1. J. W. Spinks and R. V. Woods, “An Introduction to Radiation Chemistry,” John Wiley and Sons, New York, 1964.

    Google Scholar 

  2. E. J. Hart, Radiat. Res. 3, 285, 1972.

    Google Scholar 

  3. M. Anbar and P. Neta, Int. J. Appl. Radiat. Isotopes 18, 493 1967.

    Article  Google Scholar 

  4. J. J. Weiss, Prog. Nucleic Acids Res. 3, 103, 1964.

    Article  Google Scholar 

  5. G. Scholes, in “Radiation Chemistry of Aqueous Systems,” G. Stein, Editor, pp. 259, The Weizman Science Press, Israel, 1968.

    Google Scholar 

  6. G. E. Adams, in “Advances in Radiation Chemistry,” M. Burton and J. L. Magee, Editors, pp. 125- Wiley-Interscience, New York, 1972.

    Google Scholar 

  7. R. Teoule and J. Cadet, Bull. Soc. Chim., France 28, 927, 1970.

    Google Scholar 

  8. J. Cadet and R. Teoule, Comptes Rend. Acad. Sc., Paris, 274 C, 917, 1972.

    Google Scholar 

  9. G. A. Infante, E. J. Fendler and J. H. Fendler, Radiat. Res. Rev. 4, 301, 1973, and references cited therein.

    Google Scholar 

  10. J. Hutterman, W. Kohnlein, R. Teoule and A. J. Bertinchamps, “Effects of Ionizing Radiation on DNA,” Springer-Verlag, Berlin, 1978 and references cited therein.

    Google Scholar 

  11. J. Campos, O. Portuondo, S. Santiago and G. A. Infante, Science Ciencia, 1, 3, 1974.

    Google Scholar 

  12. G. A. Infante, L. Velez, G. Cruz, and C. Rivera, Radiat. Res., 70, 648, 1977.

    Google Scholar 

  13. J. M Gebieki and A. O. Allen, J. Phys. Chem. 73, 2443, 1969.

    Article  Google Scholar 

  14. J. H. Fendler and L. K. Patterson, J. Phys. Chem. 74, 4608, 1970.

    Article  Google Scholar 

  15. E. J. Fendler and J. H. Fendler, Prog. Phys. Org. Chem. 7, 229 1970.

    Article  Google Scholar 

  16. L. K. Patterson, K. M. Bansal and J. H. Fendler, Chem. Commun., 152, 1971.

    Google Scholar 

  17. K. M. Bansal, L. K. Patterson, E. J. Fendler and J. H. Fendler, Int. J. Radiat. Phys. Chem., 3, 321, 1971.

    Article  Google Scholar 

  18. J. H. Fendler, E. J. Fendler, G. Bogan, L. K. Patterson and K. M. Bansal, Chem. Commun, 269, 1972

    Google Scholar 

  19. L. K. Patterson, K. M. Bansal, G. Bogan, G. A. Infante, E. J. Fendler, and J. H. Fendler, J. Am. Chem. Soc., 94, 9028, 1972.

    Article  Google Scholar 

  20. J. H. Fendler, G. Bogan, E. J. Fendler, G. A. Infante, and P. Jirathana, in “Reaction kinetics in Micelles,” E. H. Cordes Editor, pp. 53, Plenum Press, New York, 1973.

    Google Scholar 

  21. J. H. Fendler, G. A. Infante, P. Jirathana, and E. J. Fendler, J. C. S. Faraday I 70, 1171, 1974.

    Article  Google Scholar 

  22. G. A. Infante, Ph.D. Thesis, Texas A&M University, College Station, Texas, 1973.

    Google Scholar 

  23. M. G. Gol’ dfel’ d, R. A. Davydou, R. M. Makovskii, and A. B. Shapiro, Russian J. Phys. Chem. 45, 1337, 1971.

    Google Scholar 

  24. R. M. Devydou and M. G. Gol’dfel’ d, Russian J. Phys. Chem. 46, 603, 1972.

    Google Scholar 

  25. M. Gratzel and J. K. Thomas, J. Am. Chem. Soc. 95, 6585, 1973.

    Google Scholar 

  26. C. L. Greenstock and I. Dunlop, Int. J. Radiat. Phys. Chem., 5, 231, 1973.

    Article  Google Scholar 

  27. S. C. Wallace and J. K. Thomas, Radiat. Res. 54, 49, 1973.

    Article  PubMed  Google Scholar 

  28. J. H. Fendler, A. A. Gillis, and N. V. Klassen, J. C. S. Faraday I, 70, 145, 1972.

    Article  Google Scholar 

  29. M. Gratzel, J. K. Thomas, and L. K. Patterson Chem. Phys. Letters 29, 393, 1974.

    Article  Google Scholar 

  30. L. K. Patterson and M. Gratzel, J. Phys. Chem. 79, 956, 1975.

    Article  Google Scholar 

  31. M. A. J. Rodgers, D. C. Foyt and Z. A. Zimek, Rad. Res. 75, 296, 1978.

    Article  Google Scholar 

  32. J. A. Raleigh and W. Kremers, Int. J. Rad. Biol. 34, 439, 1978.

    Article  Google Scholar 

  33. A. J. Frank, in “Micellization, Solubilization and Microemulsions” K. L. Mittal, Editor, pp. 549- Plenum Press, New York, 1977.

    Google Scholar 

  34. K. Kalyanasundaram and J. K. Thomas, ibid., pp. 569.

    Google Scholar 

  35. L. K. Patterson, and L. L. Redpath, ibid., pp. 589.

    Google Scholar 

  36. L. K. Patterson and J. Lilie, Int. J. Radiat. Phys. Chem. 6, 129, 1974.

    Article  Google Scholar 

  37. J. A. Myers, L. D. Moore, W. L. Whitter, S. L. Council, R. M. Waldo, J. L. Lanier and B. U. Omoji, J. Org. Chem. 45, 1202, 1980.

    Google Scholar 

  38. G. A. Infante, C. Camacho, E. Pagan, A. Santos, D. Cruz, R. Perez, J. Correa, J. A. Myers, L. D. Moore and W. Whitter, Cancer Clinical Trials 00, 000, 1980.

    Google Scholar 

  39. E. J. Land, and A. J. Swallow, J. Biol. Chem. 245, 1890, 1970.

    PubMed  Google Scholar 

  40. R. L. Willson, Trans, Fara. Soc. 67, 3020, 1971.

    Article  Google Scholar 

  41. J. H. Fendler and E. J. Fendler, in “The Chemistry of Quinoid Compounds,” S. Patai, Editor, pp. 539, John Wiley, New York, 1974.

    Google Scholar 

  42. B. Pullman and A. Pullman, “Quantum Biochemistry,” Interscience Publishing Co., New York, 1973.

    Google Scholar 

  43. J. H. Fendler, E. J. Fendler, G. A. Infante, P. S. Shih and L. K. Patterson, J. Am. Chem. Soc. 97, 89, 1975.

    Article  Google Scholar 

  44. J. H. Fendler, E. J. Fendler, G. A. Infante, and L. K. Patter-son, 1975, unpublished data.

    Google Scholar 

  45. G. A. Infante, F. Garcia, B. Irizarry, and J. Negron, Science-Ciencia, 4, 5, 1976.

    Google Scholar 

  46. D. Rivera, Morales, L. Mercado and G. A. Infante, Science-Ciencia, 6, 26, 1978.

    Google Scholar 

  47. E. Orta, L. Velez, G. Yordan, L. Peguero, and G. A. Infante, Science-Ciencia, 6, 14, 1978.

    Google Scholar 

  48. G. A. Infante, L. Velez, G. Yordan and L. Peguero, Rad. Res. 74, 487, 1978.

    Google Scholar 

  49. G. A. Adams, D. C. Azquith, M. E. Watts and C. E. Smithen, Nature, London, New Biol., 239, 23, 1972.

    Article  Google Scholar 

  50. D. Denekamp and B. D, Michael, Nature, London, New Biol., 239, 21, 1972.

    Google Scholar 

  51. C. L. Greenstock and I. Dunlop, Radiat. Res., 56, 428, 1973.

    Article  PubMed  Google Scholar 

  52. G. E. Adams, I. R. Flockhart, C. E. Smithen, I. J. Stratfard, P. Wardman, and M. E. Watts, Radiat. Res., 67, 9, 1976.

    Article  PubMed  Google Scholar 

  53. D. F. Fowler, G. E. Adams and J. Denekamp, Cancer Trest. Rev., 3, 227, 1976.

    Article  Google Scholar 

  54. K. C. Agrawal, K. B. Bears, R. K. Schgal, D. N. Brown, P. E. Rist and W. D. Rupp, J. Med. Chem., 22, 583, 1979.

    Article  PubMed  Google Scholar 

  55. G. E. Adam, E. D. Clarke, I. R. Flockhart, R. S. Jacobs, D. S. Sehmi, I. J. Stratford, P. Wardman, M. E. Watts, J. Parrick, R. G. Wallace and C. E. Smithen, Int. J. Radiat. Biol. 35, 133 1979.

    Article  Google Scholar 

  56. G. E. Adams, E. D. Clarke, P. Gray, R. S. Jacobs, I. J. Stratford, P. Wardman, M. E. Watts, J. Parrick, R. G. Wallace, C. E. Smithen, Int. J. Radiat. Biol. 35, 151 1979.

    Article  Google Scholar 

  57. J. A. Myers, L. D. Moore Jr., W. L. Whitter, S. L. Council, R. M. Waldo, J. L. Lanier and B. U. Omoji, J. Org. Chem. 45, 1202, 1980.

    Google Scholar 

  58. J. Correa, G. A. Infante, A. Santos, P. Gonzalez and R. Alvarez, Rad. Res. 83, 373, 1980.

    Google Scholar 

  59. G. A. Infante, C. Camacho, E. Pagan, A. Santos, D. Cruz, R. Perez, J. Correa, J. A. Myers, L. D. Moore Jr. and W. Whitter, Cancer Clinical Trials 00, 000, 1980.

    Google Scholar 

  60. G. A. Infante, A. Santos, P. Gonzalez, D. Cruz, J. Correa, J. A. Myers, L. D. Moore Jr., W. L. Whitter and P. Neta, 1980, Radiat. Res., submitted for publication.

    Google Scholar 

  61. J. H. Fendler and A. Romero, Life Sciences 20, 1109, 1977.

    Article  PubMed  Google Scholar 

  62. G. Gregoriadis, New Scientist 60, 890, 1973.

    Google Scholar 

  63. G. Gregoriadis, C. P. Swain, E. J. Willis, A. S. Tavill, The Lancet, 1313, 1974.

    Google Scholar 

  64. G. Gregoriadis, New England J. Med. 295, 704, 1976.

    Article  Google Scholar 

  65. D. A. Tyrrell, T. D. Heath, C. M. Colley and B. E. Ryman, Biochim. Biophys. Acta 457, 259, 1976.

    PubMed  Google Scholar 

  66. J. H. Fendler, Acc. Chem. Res. 13, 7, 1980.

    Article  Google Scholar 

  67. G. A. Infante, J. A. Myers, J. N. Correa and J. R. Escabi, 1980, unpublished data.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Dept. of Chemistry, Catholic University of Puerto Rico, Ponce, PR 00731, Puerto Rico

    Gabriel A. Infante

  2. North Carolina Central University, Durham, North Carolina, 27707, USA

    John A. Myers

Authors
  1. Gabriel A. Infante
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  2. John A. Myers
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Editor information

Editors and Affiliations

  1. IBM Corporation, Hopewell Junction, New York, USA

    K. L. Mittal

  2. The Standard Oil Company (Ohio), Cleveland, Ohio, USA

    E. J. Fendler

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© 1982 Plenum Press, New York

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Infante, G.A., Myers, J.A. (1982). Micellar Effects on the Radiation Chemistry of Biologically Important Compounds. In: Mittal, K.L., Fendler, E.J. (eds) Solution Behavior of Surfactants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3494-1_23

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  • DOI: https://doi.org/10.1007/978-1-4613-3494-1_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3496-5

  • Online ISBN: 978-1-4613-3494-1

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