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Structure and Hydrophobic Bonding: Concepts and Applications to Anesthesia

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Solution Behavior of Surfactants

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Abstract

Hydrophobic bonding is related to the three dimensional hydrogen-bonded structure in liquid water. This skeletal structure allows the existence of cavities capable of accommodating small non-polar moieties and also the formation of cavities by the larger non-polar groups on dissolution. The limit of this interstitial dissolution at a given temperature is the onset of hydrophobic bonding such as micellization, saturation solubility or the intramolecular aggregation of non-polar side chains in proteins. The stronger the skeletal structure the more stable the natural cavities and the higher the solubility of small non-polar molecules. Weaker skeletal structures accommodate relatively large non-polar molecules (moieties) better than the stronger skeletal structures. This explains the solubility of argon, hydrocarbons, amino acids and micellization in light water, heavy water and in aqueous urea solutions.

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Author information

Authors and Affiliations

  1. Chemistry Department, University of Kuwait, Kuwait

    Mohammad Abu-Hamdiyyah

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  1. Mohammad Abu-Hamdiyyah
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Editors and Affiliations

  1. IBM Corporation, Hopewell Junction, New York, 12533, USA

    K. L. Mittal

  2. The Standard Oil Company (Ohio), Cleveland, Ohio, 44128, USA

    E. J. Fendler

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© 1982 Plenum Press, New York

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Abu-Hamdiyyah, M. (1982). Structure and Hydrophobic Bonding: Concepts and Applications to Anesthesia. In: Mittal, K.L., Fendler, E.J. (eds) Solution Behavior of Surfactants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3491-0_39

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  • DOI: https://doi.org/10.1007/978-1-4613-3491-0_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3493-4

  • Online ISBN: 978-1-4613-3491-0

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