Abstract
Solubilization by bile salts is a fundamentally important process in lipid biochemistry. The interaction of long-chain, aliphatic compounds and other lipidic substances with bile salt micelles to produce solubilized aggregates provides a transport mechanism for the absorption of the fatty materials in the small intestine. The basic energetics of formation of the aggregates determines their stability and solution characteristics, and thus are important in understanding the behavior of the bile salts in the solubilization process. This paper presents a summary of the thermodynamics of transfer of a series of fatty alcohols from aqueous to the bile salt micelle phase. Free energy, enthalpy, entropy, and heat capacity effects are presented, and analyzed in terms of the additive contributions to the properties of the solutes.
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© 1982 Plenum Press, New York
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Spink, C.H., Colgan, S. (1982). Thermodynamics of Bile Salt Interactions with Lipidic Substances. In: Mittal, K.L., Fendler, E.J. (eds) Solution Behavior of Surfactants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3491-0_33
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DOI: https://doi.org/10.1007/978-1-4613-3491-0_33
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