Abstract
We have employed laser light scattering methods to deduce the size, shape, structure and polydispersity of the macromolecular complexes formed in aqueous systems containing: bile salts, lecithin and cholesterol. Such studies have revealed an extraordinary variety in the size and structure of the aggregates as well as their patterns of aggregation. Bile salts form micelles whose size and shape varies from globular (radius~10Å) to elongated (length >200Å) as functions of concentration, bile salt species, temperature and added NaCl. The solubilization of lecithin by bile salts involves a unique mixed micellar structure that is disc shaped. The radii of these discs increase non-linearly (20→300Å) with the L/BS ratio and appear to diverge as the mixed micellar phase limit is approached. Above this limit the discs may transform into metastable liposomal structures. The solubilization of cholesterol is achieved by its incorporation into bile salt and bile salt-lecithin micelles.
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© 1982 Plenum Press, New York
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Mazer, N.A., Carey, M.C., Benedek, G.B. (1982). Micellization, Solubilization and Microemulsions in Aqueous Biliary Lipid Systems. In: Mittal, K.L., Fendler, E.J. (eds) Solution Behavior of Surfactants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3491-0_31
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DOI: https://doi.org/10.1007/978-1-4613-3491-0_31
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