Abstract
Before a regulatory agency such as the U.S. Environmental Proection Agency (EPA) can use mutagenicity data to assess genetic risk, many societal and bureaucratic events must occur. First, the Congress must recognize the need for environmental legislation to protect the public and the environment against exposure to harmful toxicants. This recognition is initiated primarily by public episodes and awareness, such as the kepone and PCB incidences, which prompt the Federal Government to take appropriate action through legislation.
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References
U. S. Environmental Protection Agency, Interim procedures and guidelines for health risk and economic impact assessments of suspected carcinogens, Federal Register 51:21402–21405, May 25, 1976.
U. S. Environmental Protection Agency, Notice of RPAR for ethylene dibromide, Federal Register 42:63134–63160, December 14, 1977.
U.S. Environmental Protection Agency, Proposed guidelines for registering pesticides in the U. S. Hazard evaluation: Humans and domestic animals, Federal Register 43:37400–37403, August 22, 1978.
U. S. Environmental Protection Agency, Mutagenicity risk assessments proposed guidelines, Federal Register 45:74984–74988, November 13, 1980.
W. L. Russell, X-ray-induced mutations in mice, Cold Spring Harbor Symposium on Quantitative Biology 16: 327–336 (1951).
W. L. Russell, X-ray-induced mutations in mice, Cold Spring Harbor Symposium on Quantitative Biology 16: 327–336 (1951).
pertinent references cited in 4.
United Nations Scientific Committee on the Effects of Atomic Radiation Sources and Effects of Ionizing Radiation, Report to the General Assembly, United Nations, New York, (1977).
W. R. Lee, Final report on EDB to the Toxicology Branch, Health Effects Division Office of Pesticides Program, U. S. Environmental Protection Agency (1980).
U. S. Environmental Protection Agency, Office of Pesticides Programs, Ethylene Dibromide Position Document 2 /3, (1980).
E. Jackson, P. Voytek, Comparison of estimated human mutagenicity versus carcinogenicity to ethylene dibromide (EDB), in preparation, (1981).
J. McCann, B. N. Ames, The Salmonella/microsome mutagenicity test: predictive value for animal carcinogenicity, in: “Origins of Human Cancer, Book C”, H. H. Hiatt, J. D. Watson, J. A. Winstin, eds., Cold Spring Harbor Conferences on Cell Proliferation, Cold Spring Harbor, NY, 1431–1450 (1977).
Biological Effects of Ionizing Radiation II Report, Report of the Advisory Committee, National Academy of Sciences, National Research Council, Washington, D. C. (1981).
P. Z. Daffer, K. S. Crump, M. D. Masterman, Asymptotic theory for analyzing dose-response survival data with application to the low-dose extrapolation problem, Mathematical Biosciences 50: 207–230 (1980).
U. S. Environmental Protection Agency, The cancer assessment group’s updated quantitative risk assessment on ethylene dibromide, in preparation, (1981).
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© 1982 Plenum Press, New York
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Voytek, P. (1982). Policy and Procedures for Using Mutagenicity Data in Assessing Genetic Risk. In: Tice, R.R., Costa, D.L., Schaich, K.M. (eds) Genotoxic Effects of Airborne Agents. Environmental Science Research, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3455-2_42
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DOI: https://doi.org/10.1007/978-1-4613-3455-2_42
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