Skip to main content

Policy and Procedures for Using Mutagenicity Data in Assessing Genetic Risk

  • Chapter
Genotoxic Effects of Airborne Agents

Part of the book series: Environmental Science Research ((ESRH,volume 25))

Abstract

Before a regulatory agency such as the U.S. Environmental Proection Agency (EPA) can use mutagenicity data to assess genetic risk, many societal and bureaucratic events must occur. First, the Congress must recognize the need for environmental legislation to protect the public and the environment against exposure to harmful toxicants. This recognition is initiated primarily by public episodes and awareness, such as the kepone and PCB incidences, which prompt the Federal Government to take appropriate action through legislation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. U. S. Environmental Protection Agency, Interim procedures and guidelines for health risk and economic impact assessments of suspected carcinogens, Federal Register 51:21402–21405, May 25, 1976.

    Google Scholar 

  2. U. S. Environmental Protection Agency, Notice of RPAR for ethylene dibromide, Federal Register 42:63134–63160, December 14, 1977.

    Google Scholar 

  3. U.S. Environmental Protection Agency, Proposed guidelines for registering pesticides in the U. S. Hazard evaluation: Humans and domestic animals, Federal Register 43:37400–37403, August 22, 1978.

    Google Scholar 

  4. U. S. Environmental Protection Agency, Mutagenicity risk assessments proposed guidelines, Federal Register 45:74984–74988, November 13, 1980.

    Google Scholar 

  5. W. L. Russell, X-ray-induced mutations in mice, Cold Spring Harbor Symposium on Quantitative Biology 16: 327–336 (1951).

    Google Scholar 

  6. W. L. Russell, X-ray-induced mutations in mice, Cold Spring Harbor Symposium on Quantitative Biology 16: 327–336 (1951).

    Google Scholar 

  7. pertinent references cited in 4.

    Google Scholar 

  8. United Nations Scientific Committee on the Effects of Atomic Radiation Sources and Effects of Ionizing Radiation, Report to the General Assembly, United Nations, New York, (1977).

    Google Scholar 

  9. W. R. Lee, Final report on EDB to the Toxicology Branch, Health Effects Division Office of Pesticides Program, U. S. Environmental Protection Agency (1980).

    Google Scholar 

  10. U. S. Environmental Protection Agency, Office of Pesticides Programs, Ethylene Dibromide Position Document 2 /3, (1980).

    Google Scholar 

  11. E. Jackson, P. Voytek, Comparison of estimated human mutagenicity versus carcinogenicity to ethylene dibromide (EDB), in preparation, (1981).

    Google Scholar 

  12. J. McCann, B. N. Ames, The Salmonella/microsome mutagenicity test: predictive value for animal carcinogenicity, in: “Origins of Human Cancer, Book C”, H. H. Hiatt, J. D. Watson, J. A. Winstin, eds., Cold Spring Harbor Conferences on Cell Proliferation, Cold Spring Harbor, NY, 1431–1450 (1977).

    Google Scholar 

  13. Biological Effects of Ionizing Radiation II Report, Report of the Advisory Committee, National Academy of Sciences, National Research Council, Washington, D. C. (1981).

    Google Scholar 

  14. P. Z. Daffer, K. S. Crump, M. D. Masterman, Asymptotic theory for analyzing dose-response survival data with application to the low-dose extrapolation problem, Mathematical Biosciences 50: 207–230 (1980).

    Article  MathSciNet  MATH  Google Scholar 

  15. U. S. Environmental Protection Agency, The cancer assessment group’s updated quantitative risk assessment on ethylene dibromide, in preparation, (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Voytek, P. (1982). Policy and Procedures for Using Mutagenicity Data in Assessing Genetic Risk. In: Tice, R.R., Costa, D.L., Schaich, K.M. (eds) Genotoxic Effects of Airborne Agents. Environmental Science Research, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3455-2_42

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3455-2_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3457-6

  • Online ISBN: 978-1-4613-3455-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics