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Comparative Chemical Mutagenesis pp 27–68Cite as

Mutagenicity of Selected Chemicals in the Salmonella/Microsome Mutagenicity Test

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Abstract

The Salmonella/microsome mutagenicity test provides a simple, economical method for detecting chemical mutagens. Compounds are tested on Petri plates with several specially constructed mutants Salmonella typhimurium which have been selected for their sensitivity and specificity in being reverted from a histidine requirement back to prototropy. Liver homogenates can be added directly to the Petri plates, thus incorporating an important aspect of mammalian metabolism into the in vitro test. The system has been recently reviewed (1) and the test method described in detail (2).

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Authors and Affiliations

  1. Department of Biochemistry, University of California at Berkeley, Berkeley, California, 94720, USA

    Lynne Haroun & Bruce N. Ames

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  1. Lynne Haroun
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  2. Bruce N. Ames
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Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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© 1981 Plenum Press, New York

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Haroun, L., Ames, B.N. (1981). Mutagenicity of Selected Chemicals in the Salmonella/Microsome Mutagenicity Test. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_4

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  • DOI: https://doi.org/10.1007/978-1-4613-3409-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3411-8

  • Online ISBN: 978-1-4613-3409-5

  • eBook Packages: Springer Book Archive

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