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Comparative Mutagenicity of Mitomycin C

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Comparative Chemical Mutagenesis

Abstract

Mitomycin C (MC) was first isolated from Streptomyces caesipitosus (1). It was demonstrated to have antibiotic and antitumor properties. Closely related antibiotics, designated mitomycin A and B and porfiromycin have also bee isolated (2). Mitomycins are colored, basic substances forming reddish-violet, plate or needle-shaped crystals. The antibiotic family was described as having unique, naturally occurring structural configurations, in that it represents the first recorded example of the formation by a microbial system of an aziridine group, the pyrrol-(1,2-a)- indole ring system, an aminobenzoquinone, and a pyrrolizine. The common mitomycin nucleus is termed Mitosane. The different compounds only vary by minor substituent groupings (3).

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  1. Institut für Genetik, Gesellschaft für Strahlen- und Umweltforschung, D-8042, Neuherberg bei München, Federal Republic of Germany

    Ilse-Dore Adler

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  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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Adler, ID. (1981). Comparative Mutagenicity of Mitomycin C. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_34

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  • DOI: https://doi.org/10.1007/978-1-4613-3409-5_34

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