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Comparative Mutagenicity of Methyl Methanesulfonate and Ethyl Methanesulfonate

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Comparative Chemical Mutagenesis

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Abstract

Methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) are highly mutagenic in lower organisms but only moderately carcinogenic in mice and rats. No case reports or epidemiological studies on the hazards of MMS and EMS to humans are known to the Working Group. This review summarizes and evaluates the data on genetic effects of these compounds from the aspect of their relevance to the assessment of possible genetic effects of these or related compounds in humans. First, a general summary is given of available data on MMS and EMS and some typical examples are given of dose-related effects of EMS and MMS in mice, Drosophila, and some other organisms. Then, molecular mechanisms of mutagenesis are discussed. Third, an attempt is made to assess the human hazard of these compounds on the basis of the experimental data and finally the areas requiring further investigation are considered.

With the collaboration of D. Anderson, H. Brockman, W. P. Lee, T. Matsushima, C. Nauman, J. M. Parry, R. Pertel, R. San, B. Vig and S. Wolff

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Authors and Affiliations

  1. Osaka University, Osaka, Japan

    Sohei Kondo (Faculty of Medicine)

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  1. Sohei Kondo
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Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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© 1981 Plenum Press, New York

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Kondo, S. (1981). Comparative Mutagenicity of Methyl Methanesulfonate and Ethyl Methanesulfonate. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_26

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  • DOI: https://doi.org/10.1007/978-1-4613-3409-5_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3411-8

  • Online ISBN: 978-1-4613-3409-5

  • eBook Packages: Springer Book Archive

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