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Comparative Chemical Mutagenesis pp 657–680Cite as

Mutagenicity of Selected Chemicals in the Mammalian Micronucleus Test

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Abstract

The production of micronuclei as a result of chromosome aberration has been known for many years. Only recently, how¬ever, has there been interest in micronuclei for the purpose of rapid screening of mutagens in the environment, as a result of pioneer work by Schmid et al. (1–4). In recent years, a substantial number of different classes of chemical compounds has been tested with the micronucleus test in various laboratories.

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References

  1. Boller, K., and Schmid, W. Humangenetik 11: 35–54 (1970).

    Article  Google Scholar 

  2. Matter, B., and Schmid, W. Mutat. Res. 12: 417–425 (1971).

    Article  Google Scholar 

  3. Schmid, W. Agents and Actions 3: 77–85 (1973).

    Article  Google Scholar 

  4. Schmid, W. Mutat. Res. 31: 9–15 (1975).

    Google Scholar 

  5. Schmid, W. In: Chemical Mutagens, Vol. 4, A. Hollaender, Ed., Plenum Press, New York, 1976, pp. 31–53.

    Google Scholar 

  6. Matter, B. E., and Grauwiler, J. Mutat. Res. 23: 239–249 (1974).

    Article  Google Scholar 

  7. Müller, D., Fritz, H., Langauer, M., and Strasser, F. F. In: Environmental Quality and Safety, Suppl. Vol. IV, Fluorescent Whitening Agents, F. Coulston and F. Körte, Eds., Thieme Publishers, Stuttgart, 1975, pp. 247–263.

    Google Scholar 

  8. Müller, D., Langauer, M., Rathenberg, R., Strasser, F. F., and Hess, R. Verh. Deut. Ges. Pathol. 56: 381–384 (1972).

    Google Scholar 

  9. Matter, B. E. J. Int. Med. Res. 4k: 382–392 (1976).

    Google Scholar 

  10. Hossack, D. J. N., and Richardson, J. C. Experientia 33: 377–378 (1978).

    Article  Google Scholar 

  11. Maier, P., and Schmid, W. Mutat. Res. 40: 325–338 (1976).

    Article  Google Scholar 

  12. Wild, D. Mutat. Res. 311–317 (1978).

    Google Scholar 

  13. von Ledebur, M., and Schmid, W. Mutat. Res. 19: 109–117 (1973).

    Article  Google Scholar 

  14. Friedman, M. A., and Staub, J. Mutat. Res. 43: 255–262 (1977).

    Article  Google Scholar 

  15. Heddle, J. A., and Bruce, W. R. In: Origins of Human Cancer, Vol. 4, H. H. Hiatt, J. D. Watson, and J. A. Winsten, Eds., Cold Spring Harbor Conferences, 1977.

    Google Scholar 

  16. Heddle, J. A., and Bruce, W. R. In: Progress in Genetic Toxicology, D. Scott, B. A. Bridges, and F. H. Sobels, Eds., Elsevier/North Holland Biomedical Press, Amsterdam, 197 7, pp. 265–274.

    Google Scholar 

  17. Goetz, P., Sram, R. J., and Dohnalova, J. Mutat. Res. 31: 247–254 (1975).

    Google Scholar 

  18. Matter, B. E., Jaeger, I., and Grauwiler, J. In: Experimental Model System in Toxicology and Their Significance in Man. (Proc. Soc. Study Drug Toxicol. Vol. 15) Excerpta Med. Int. Congr. Ser. No. 311, Elsevier, Amsterdam, 1974, pp. 275–279.

    Google Scholar 

  19. Heddle, J. A. Mutat. Res. 18: 187–190 (1973).

    Article  Google Scholar 

  20. Maier, P., and Schmid, W. Mutat. Res. 30: 299–302 (1975).

    Google Scholar 

  21. Frank, D. W., Trzos, R. J., and Good, P. I. Mutat. Res. 56: 311–317 (1978).

    Article  Google Scholar 

  22. Bauknecht, T., Vogel, W., Bayer, U., and Wild, D. Hum. Genet. 35: 299–307 (1977).

    Article  Google Scholar 

  23. Chaubey, R. C., Kavi, B. R., Chauhan, P. S., and Sundaram, K. Mutat. Res. 43: 441–444 (1977).

    Article  Google Scholar 

  24. Richardson, J. C. Mutat. Res. 24: 391–394 (1975).

    Google Scholar 

  25. Miller, R. C. Environ. Health Perspect. 6: 167–170 (1973).

    Article  Google Scholar 

  26. Jacquet, P., Leonard, A., and Gerber, G. B. J. Toxicol. Environ. Health 2: 619–624 (1977).

    Google Scholar 

  27. Jensen, D., and Ramel, C. Mutat. Res. 41: 311–320 (1976).

    Article  Google Scholar 

  28. Jensen, D., and Renberg, L. Chem.-Biol. Interact. 291–299 (1976).

    Google Scholar 

  29. Hite, M., Skeggs, H., Noveroske, J., and Peck, H. Mutat. Res. 40: 289–304 (1976).

    Article  Google Scholar 

  30. Weber, E., Bidwell, K., and Legator, M. S. Mutat. Res. 28: 101–106 (1975).

    Article  Google Scholar 

  31. Goodman, D. R., Hakkinen, P. J., Nemenzo, J. H., and Vore, M. Mutat. Res. 48: 295–306 (1977).

    Article  Google Scholar 

  32. Jellema, M. M., and Schardein, J. L. Toxicol. Appl. Pharmacol 31: 107–113 (1975).

    Article  Google Scholar 

  33. Jellema, M. M., and Schardein, J. L. Toxicol. Appl. Pharmacol 27: 422–430 (1974).

    Article  Google Scholar 

  34. Seiler, J. P. Experientia 31: 214–215 (1975).

    Article  MathSciNet  Google Scholar 

  35. Hossain, M. M., Huismans, J. W., and Diehl, J. F. Toxicology 6: 243–251 (1976).

    Article  Google Scholar 

  36. Heddle, J. A., and Carrano, A. V. Mutat. Res. 44: 63–69 (1977).

    Article  Google Scholar 

  37. Tates, A. D., and Natarajan, A. T. Mutat. Res. 37: 267–278 (1976).

    Article  Google Scholar 

  38. Tates, A. D., Natarajan, A. T., de Vogel, N., and Meijers, M. Mutat. Res. 44: 87–95 (1977).

    Article  Google Scholar 

  39. Goetz, P., Sràm, R. J., Kodytkova, I., Dohnalova, J., Dostalova, O., and Bartova, J. Mutat. Res. 41: 143–152 (1976)

    Article  Google Scholar 

  40. Urwin, C., Richardson, J. C., and Palmer, A. K. Mutat. Res. 40: 43–46 (1976).

    Article  Google Scholar 

  41. Matter, B. E., and Grauwiler, J. Mutat. Res. 29: 198–199 (1975).

    Google Scholar 

  42. Machemer, L., and Lorke, D. Arch. Toxicol. 39: 187–197 (1978)

    Article  Google Scholar 

  43. Schupbach, M., and Hummler, H. Mutat. Res. 56: 111–120 (1978)

    Google Scholar 

  44. Seiler, J. P. Mutat. Res. 48: 225–236 (1977).

    Article  Google Scholar 

  45. Aeschbacher, H. U., Gottwick, D., and Wurzner, H. P. Mutat. Res. 71–80 (1977).

    Google Scholar 

  46. Seiler, J. P. Mutat. Res. 40: 339–348 (1976).

    Article  Google Scholar 

  47. Tsuchimoto, T., and Matter, B. E. Mutat. Res. 46: 240 (1977)

    Google Scholar 

  48. Seiler, J. P. In: The Prediction of Chronic Toxicity from Short Term Studies (Proc. Soc. Study Drug Tox., Vol. 17), Excerpta Medica Int. Congr. Series No. 376, Elsevier, Amsterdam, 1975, pp. 398–404.

    Google Scholar 

  49. Jensen, D., and Renberg, L. Chem.-Biol. Interact. 14: 291–299 (1976).

    Article  Google Scholar 

  50. Perry, P., and Evans, H. J. Nature 258: 121–125 (1975).

    Article  ADS  Google Scholar 

  51. Natarajan, A. T., Tates, A. D., van Buul, P. P. W., Meijers, M., and De Vogel, N. Mutat. Res. 37: 83–90 (1976).

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Biological and Medical Research Division, Sandoz Ltd., Basle, Switzerland

    B. E. Matter

  2. Zentrallabor für Mutagenitätsprüfung der Deutschen Forschungsgemeinschaft, Freiburg, Germany

    D. Wild

Authors
  1. B. E. Matter
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  2. D. Wild
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Editor information

Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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© 1981 Plenum Press, New York

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Matter, B.E., Wild, D. (1981). Mutagenicity of Selected Chemicals in the Mammalian Micronucleus Test. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_22

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  • DOI: https://doi.org/10.1007/978-1-4613-3409-5_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3411-8

  • Online ISBN: 978-1-4613-3409-5

  • eBook Packages: Springer Book Archive

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