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Mutagenicity of Selected Chemicals in the Mammalian Dominant Lethal Assay

  • Chapter
Comparative Chemical Mutagenesis

Abstract

Compounds such as triethylenemelamine, EMS, cyclophosphamide, and Myleran are widely used model mutagens, and a wealth of information on their dominant lethal activity has been published. For other chemicals, such as Aflatoxin B1, DEN, and DMN, dominant lethal data are very sparse, perhaps because they have been regarded as model carcinogens rather than mammalian mutagens.

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Author information

Authors and Affiliations

  1. Shell Research Ltd., Shell Toxicology Laboratory, Sittingbourne Research Centre (Tunstall), Sittingbourne Kent, ME9 8AG, England

    B. J. Dean

  2. ICI Ltd., Central Toxicology Laboratory, Alderley Park Nr. Macclesfield, Cheshire, SK10 7TJ, England

    D. Anderson

  3. Institute of Hygiene and Epidemiology, Srobarova 48, 100 42, Praha 10, Czechoslovakia

    R. J. Šrám

Authors
  1. B. J. Dean
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  2. D. Anderson
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  3. R. J. Šrám
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Editor information

Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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© 1981 Plenum Press, New York

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Dean, B.J., Anderson, D., Šrám, R.J. (1981). Mutagenicity of Selected Chemicals in the Mammalian Dominant Lethal Assay. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_18

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  • DOI: https://doi.org/10.1007/978-1-4613-3409-5_18

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