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Mutagenicity of Selected Chemicals in Mammalian in Vitro Cytogenetic Systems

  • Chapter
Comparative Chemical Mutagenesis

Abstract

The study of structural chromosome aberrations in mammalian cells grown in tissue culture offers the opportunity of observing directly the mutagenic effects of various agents without the need of maintaining an animal colony. A myriad of cell lines exists offering the investigator a wide choice of mammalian species, and in many instances a variety of karyological types within a species, e.g., unique marker chromosomes.

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Author information

Authors and Affiliations

  1. Corporate Medical Affairs, Allied Chemical Corporation, Morristown, New Jersey, 07960, USA

    J. G. Brewen

  2. Dept. of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Sylvius Laboratories, Leiden, The Netherlands

    A. T. Natarajan

  3. Institut für Genetik der Freien Universitat Berlin, 1 Berlin 33, Arnimallee 5-7, W. Germany

    G. Obe

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  1. J. G. Brewen
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  2. A. T. Natarajan
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  3. G. Obe
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Editor information

Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. De Serres  & Michael D. Shelby  & 

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© 1981 Plenum Press, New York

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Brewen, J.G., Natarajan, A.T., Obe, G. (1981). Mutagenicity of Selected Chemicals in Mammalian in Vitro Cytogenetic Systems. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_17

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  • DOI: https://doi.org/10.1007/978-1-4613-3409-5_17

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