Abstract
It is well recognized that allergic tissue reactions involving mast cell degranulation are accompanied by the infiltration of inflammatory cells, including neutrophils and eosinophils. Experimentally, it can be shown that following the interaction of specific antigen with mast cell-bound IgE (or equivalent homocytotropic antibody such as guinea pig IgG1 or rat IgG2a) a mechanism is inititated which results in the local accumulation of various cell types. For Instance, when IgG1 was introduced into the skin of a normal guinea pig and, after a latent period, blue dye and specific antigen was injected Intravenously (as in the usual passive cutaneous anaphylatic reaction) cell accumulation could be observed at the site of the blueing reaction when the tissue was excised at time intervals after antigen challenge1. The first cells observed were neutrophils and these were present in large numbers at 4 hr. Eosinophils appeared in appreciable numbers at 8 hr after challenge and were present in largest aumbers at 12 hr. After this time macrophages were the prominant cells and they continued to accumulate for up to 72 hr (at which time the experiment was terminated). Similar histological findings have been observed in the skin of non-human primates (marmosets) using human IgE and pollen allergen2.
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References
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© 1982 Plenum Press, New York
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Kay, A.B. (1982). Neutrophils and Eosinophils in IgE-Dependent Allergic Tissue Reactions. In: Cumming, G., Bonsignore, G. (eds) Cellular Biology of the Lung. Ettore Majorana International Science Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3403-3_5
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DOI: https://doi.org/10.1007/978-1-4613-3403-3_5
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