Lavage Eosinophils and Histamine

  • P. L. Haslam
  • A. Dewar
  • M. Turner-Warwick
Part of the Ettore Majorana International Science Series book series (SIOR, volume 1)

Abstract

In recent years, development of the technique of bronchoalveolar lavage has provided a simple and safe way of obtaining samples of inflammatory cells and other components which accumulate in the air spaces of the lungs as a consequence of disease. These components can be examined free from the tissues, and are providing a great deal more information about inflammatory processes in different lung disorders. In particular, bronchoalveolar lavage has been used to study interstitial disorders of the lung including granulomatous lung disorders, namely sarcoidosis and extrinsic allergic alveolitis and interstitial fibrosing lung disorders, including asbestosis and cryptogenic fibrosing alveolitis (synonym: idiopathic pulmonary fibrosis). One of the main findings in these samples is that while lavage lymphocyte increases are a striking feature of the granulomatous lung disorders, by contrast lavage neutrophil increases are the most striking feature of interstitial fibrosis1.

Keywords

Lymphoma Corticosteroid Tuberculosis Histamine Prostaglandin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Turner-Warwick M., Haslam P.L., Lujoszek A.m Townsend P., Allan F., du Bois R.M., Turton C.W.G. and Collins J.V. (1981). Cells, enzymes and interstitial lung disease. Journal of the Royal College of Physicians of London; 15, 5–16.Google Scholar
  2. 2.
    Haslam P.L., Turton C.W.G., Lukoszek A., Salsbury A.J., Dewar A., Collins J.V. and Turner-WarwickM. (1980). Bronchoalveolar lavage fluid cell counts in cryptogenic fibrosing alveolitis and their relation to therapy. Thorax; 35 328–339.CrossRefGoogle Scholar
  3. 3.
    Read J. (1958). The pathogenesis of the Hamman-Rich syndrome: a review from the standpoint of possible allergic aetiology. American Reviews of Tuberculosis; 78, 353–367.Google Scholar
  4. 4.
    Rudd R.M., Haslam P.L. and Turner-Warwick M. (1981). Cryptogenic fibrosing alveolitis: relationships of pulmonary physiology and bronchoalveolar lavage to respond to treatment and prognosis. American Review of Respiratory Disease (in press).Google Scholar
  5. 5.
    Koing W., Czarnetzki B.M. and Lichtenstein L.M. (1976). Eosinophil chemotactic factor (ECF) II. Release from human polymorphonuclear leucocytes during phagocytosis. Journal of Immunology; 117, 235–241.Google Scholar
  6. 6.
    Sain-Remy J-M.R. and Cole P.J. (1980). Interactions of crysotile asbestos fibres with the complement system. Immunology; 41 431–437.Google Scholar
  7. 7.
    Haslam P.L., Cromwell 0., Dewar A. and Turner-Warwick M. (1981). Evidence of increased histamine levels in lung lavage fluids from patients with cryptogenic fibrosing alveolitis. Clinical and Experimental Immunology; 44, (in press).Google Scholar
  8. 8.
    Askenase P.W. (1980). Effector cells in late and delayed hypersensitivity reactions that are dependent of antibodies or T cells. In “Fourth International Congress of Immunology, Progress in Immunology IV”. Editied by M. Fougereau and J. Dausset, p. 829–845.Google Scholar
  9. 9.
    Connell J.T. (1968). Morphological changes in eosinophils in allergic disease. The Journal of Allergy; 41 1–9.CrossRefGoogle Scholar
  10. 10.
    Zucker-Franklin D. (1968). Electron microscopic studies of human granulocytes: structural variations related to function. Seminars in Haematology; 5 109–133.Google Scholar
  11. 11.
    Spry C.K.F and Tai P.C. (1976). Studies on blood eosinophils II. Patients with Loffler’s cardiomyopathy. Clinical and Experimental Immunology; 24 423–434.Google Scholar
  12. 12.
    Parmley R.T. and Spicer S.S. (1975). Altered tissue eosinophils in Hodgkin’s disease. Experimental and Molecular Pathology; 23, 70–82.CrossRefGoogle Scholar
  13. 13.
    Tai P.C. and Spry C.J.F. (1980). Enzymes altering the binding capacity of human blood eosinophils for IgG antibody coated erythrocytes (EA). Clinical and Experimental Immunology; 40, 207–219.Google Scholar
  14. 14.
    Anwar A.R.E. and Kay A.B. (1978). Enhancement of human eosinophil complement receptors by pharmacologic mediators. Journal of Immunology; 121, 1245–1250.Google Scholar
  15. 15.
    Litt M. (1964). Studies in experimental eosiniphilia VI. Uptake of immune complexes by eosinophils. Journal of Cell Biology; 23 355–361.CrossRefGoogle Scholar
  16. 16.
    Takenaka T., Okuda M., Dawabori S. and Kubo K. (1977). Extracellular release of peroxidase from eosinophils be interaction with immune complexes. Clinical and Experimental Immunology; 28 56–60.Google Scholar
  17. 17.
    Gleich G.J., Loegering D.A., Mann K.G. and Maldonado J.E. (1976). Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. Journal of Clinical Investigation; 57 633–640.CrossRefGoogle Scholar
  18. 18.
    Olsson I. and Venge P. (1974). Cationic proteins of human granulocytes II. Separation of the cationic proteins of the granules of leukemic myeloid cells. Blood; 44 235–246.Google Scholar
  19. 19.
    Gleich G.J., Frigas E., Loegering D.A., Wassom D.L. and Steinmuller D. (1979). Cytotoxic properties of the eosinophil major basic protein. Journal of Immunology; 123, 2925–2927.Google Scholar
  20. 20.
    Olsson I., Olofsson T., Venge P. and Winquist I. (1980). The eosinophil cationic protein and the eosinophil in inflammator reactions. Transactions of the Royal Society of Tropical Medicine and Hygiene; 74 (suppl.), 7–10.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • P. L. Haslam
    • 1
    • 2
  • A. Dewar
    • 1
    • 2
  • M. Turner-Warwick
    • 1
    • 2
  1. 1.Department of MedicineCardiothoracic InstituteLondonUK
  2. 2.Department of Electron MicroscopyCardiothoracic InstituteLondonUK

Personalised recommendations