The Pulmonary Endothelial Cell and the Myofibroblast

  • Donald Heath
Part of the Ettore Majorana International Science Series book series (SIOR, volume 1)


The endothelial cell and the myofibroblast of pulmonary blood vessels differ from one another in many respects. The first has a fixed ultrastructure consistent with precise biochemical functions and appears to be easily damaged by a raised intravascular pressure. The second seems to be a much tougher reserve cell, able to adapt both its form and situation to prevailing conditions in the blood vessel.


Pulmonary Artery Pulmonary Hypertension Pulmonary Trunk Cardiac Myxoma Fibrinoid Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Heath, D., Moosavi, H., and Smith, P. (1973). Ultrastructure of high altitude pulmonary oedema. Thorax, 28, 694.CrossRefGoogle Scholar
  2. Heath, D., and Smith, P. (1978). The electron microscopy of ‘fibrinoid necrosis’ in pulmonary arteries. Thorax, 33, 579.CrossRefGoogle Scholar
  3. Heath, D., and Smith, P. (1979). The pulmonary endothelial cell. Thorax, 34, 200.CrossRefGoogle Scholar
  4. Helliwell, T., Smith, P., and Heath, D. (1981). Endothelial pavement patterns in human arteries. J. Path. In press.Google Scholar
  5. Kibria, G., Heath, D., Smith, P., and Biggar, R. (1980). Pulmonary endothelial pavement patterns. Thorax, 35, 186.CrossRefGoogle Scholar
  6. Kombe, A.H., Smith, P., Heath, D., and Biggar, R. (1980). Endothelial cell pavement pattern in the pulmonary trunk in rats in chronic hypoxia. Br. J. Dis. Chest 74, 362.CrossRefGoogle Scholar
  7. Ryan, J.W. and Ryan, U.S. (1975). Metabolic activities of plasma membrane and caveolae of pulmonary endothelial cells, with a note on pulmonary prostaglandin synthetase. In Lung Metabolism, edited by A.F. Junod and R. de Haller p. 399, Academic Press, New York.Google Scholar
  8. Smith, P., and Heath, D. (1979). Electron microscopy of the plexiform lesion. Thorax, 34, 177.CrossRefGoogle Scholar
  9. Smith, P., and Heath, D. (1980). The ultrastructure of age- associated intimal fibrosis in pulmonary blood vessels. J. Path. 130, 247.CrossRefGoogle Scholar
  10. Smith, U., and Ryan, J.W. (1972). Substructural features of pulmonary endothelial caveolae cellulares. Tissue and Cell, 4, 49.CrossRefGoogle Scholar
  11. Smith, U., and Ryan, J.W. (1973). Electron microscopy of endothelial and epithelial components of the lungs: correlations of structure and function. Fed. Proc. 32, 157.Google Scholar
  12. Smith, U., Ryan, J.W., Michie, D.D., and Smith, D.S. (1971). Endothelial projections as revealed by scanning electron microscopy. Science, 173, 925.ADSCrossRefGoogle Scholar
  13. Stein, A.A., Mauro, J., Thibodeau, L., and Altey, R. (1969). The histogenesis of cardiac myxomas: relation to other proliferative diseases of subendothelial vasoformative reserve cells. In Pathology Annual edited by S.C. Sommers, vol. 4, p. 293. Butterworths, London.Google Scholar
  14. Stovin, P.G.I., Heath, D., and Khaliq, S.U. (1973). Ultrastructure of the cardiac myxoma and the papillary tumour of heart valves. Thorax, 28, 273.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Donald Heath
    • 1
  1. 1.Department of PathologyUniversity of LiverpoolUK

Personalised recommendations