Abstract
The function of the alveolar macrophage as an alveolar sentry is well established. As a sentry it has the duty to engage and destroy or capture an intruder such as a bacterium or noxious particle. If the invading force is strong it must call for reinforcements. For this it has a number of secretory products - chemotactic factors, colony stimulating factors, and signals to activate the immune system. The question which this paper will address is whether the macrophage can also serve as a sapper; may it be involved in the restructuring of the lung? Since the pulmonary architecture is determined by its connective tissue, how does the macrophage influence connective tissue?
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aalto, M., and Kulonen, E., 1979, Fractionation of connective- tissue-activating factors from the culture medium of silica-treated macrophages, Acta Path. Microbiol. Scand. Sect. C. 87: 271.
Aalto, M., Potila, M., and Kulonen, E., 1976, The effect of silica-treated macrophages on the synthesis of collagen and other proteins in vitro, Exp. Cell Res. 97: 193.
Aalto, M., Turakainen, H., and Kulonen, E., 1979, Effect of SiO2- liberated macrophage factor on protein synthesis in connective tissue in vitro, Scand. J. Lab. Invest. 39: 205.
Alitalo, K., Hovi, T., and Vaheri, A., 1980, Fibronectin is produced by human macrophages, J. Exp. Med. 151: 602.
Banda, M.J., and Werb, Z., 1981, Mouse macrophage elastase. Purification and characterization as a metalloproteinase, Biochem. J. 193: 589
Campbell, E.J., White, R.R., Senior, R.M., Rodriquez, R.R., and Kuhn, C., 1979, Receptor-mediated binding and internalization of leukocyte elastase by alveolr macrophages In vitro, J. Clin. Invest. 64: 824.
Carp, H., and Janoff, A., 1980, Potential mediator of inflammation Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha proteinase inhibitor in vitro, J. Clin. Invest. 66: 987.
DeCremoux, H., Hornbeck, W., Jaurand, M.C., Bignon, J., and Robert, L., 1978, Partial characterization of an elastase-like enzyme secreted by human and monkey alveolar macrophages, J. Pathol. 125: 171.
Doran, J.E., 1980, Cold insoluble globulin-enhanced phagocytosis of gelatinized targets by macrophage monolayers, J.R.E.S., 27:471.S
Gadek, J.E., Kelman, J.A., Fells, G.A., Weinberger, S.E., Horwitz, A.L., Reynolds, H.Y., Fulmer, J.A. and Crystal, R. G., 1979, Collagenase in the lower respiratory tract of patients with ifiopathic pulmonary fibrosis, New Engl. J. Med. 301: 737.
Galdston, M., Levytska, V., Liener, I.E., and Twumasi, D.Y., 1979, Degradation of tropoelastin and elastin substrates by human neutrophil elastase free and bound to alpha-2-macroglobulin in serum of the M and Z (Pi) phenotypes for alpha-l-antitrypsin, Am. Rev. Respir. Pis. 119: 435.
Ganrot, P.O., Laurell, C.B., and Ohlsson, K., 1970, Concentration of trypsin inhibitors of different molecular size and of albumin and haptoglobin in blood and lymph of various organs in the dog, Acta Physion. Scand, 79: 280.
Green, M.R., Lin, J.s., Berman, L.B., Osman, M.M., Cerreta, J.M., Mandly, I., and Turino, G.M., 1979, Elastolytic activity of alveolar macrophages in normal dogs and human subjects, J. Lab. Clin, Med, 94: 549.
Harrington, J.S., Ritchie, M., King, P.C., and Miller, K., 1973,. The vitro effects of silica-treated hamster macrophages on collagen production by hamster fibroblasts, J. Pathol., 109: 21.
Harris, E.D., and Krane, S.M., 1974, Collagenase, New Engl. J. Med. 291: 557, 605, 652.
Heppleston, A.G., and Styles, J.A., 1967, Activity of a macrophage factor in cllagen formation by silica, Nature 214: 521.
Hinman, L.M., Stevens, C.A., Matthay R.A., and Gee, J.B.L., 1980, Elastase and lysozyme activities in human alveolar macrophages:effects of cigarette smoking, Am. Rev. Respir. Pis. 21: 263.
Horwitz, A.L., and Crystal, R.G., 1976, Collagenase from rabbit pulmonary alveolar macrophages, Biochem. Biophys. Resj. Commun. 69: 296.
Horwitz, A.L., Kelman, J.A., and Crystal, R.G., 1976, Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell, Nature 264: 772.
Johnson, D., and Travis, J., 1979, The oxidative inactivation of human alpha-1-proteinase ihibitor: further evidence for methionine at the reactive centre, J. Biol. Chem. 254: 4022.
Jones, P.A., and Werv, Z., 1980, Degradation of connective tissue matrices by macrophges. II. Influence of matrix composition on proteolysis of glycoproteins elasin and collagen by macrophages in culture, J. Exp. Med. 152: 1527.
Kaplan, J., and Nielsen, M.L., 1979, Analysis of macrophage surface receptors. I. Binding of -macroglobulin-protease complexes to rabbir alveolar macrophages, J. Biol. Chem. 254: 7323.
Kaplan, J., and Nielsen, M.L., 1979, Analysis of macrophage surface receptors. II. Internalization of -macroglobulin-trypsin complexes by rabbit alveolar macrophages, J. Biol. Chem. 254: 7329.
Kettner, C., Shaw, E., White, R., and Janoff, A., 1981, The specificity of macrophage elastase on the insulin B-chain, Biochem. J. (in press).
Kuhn, C., and Senior, R.M., 1978, The role of elastases in the development of emphysema, Lung 155: 185.
Kuusela, P., 1978, Fibronectin binds to staphylococcus aureus, Nature 276: 718.
Levine, E.H., Senior, R.M., and Butler, J.V., 1976, The elastase activity of alveolar macrophages: measurements using synthetic substrates and elastin, Am. Rev. Respir. Pis. 113: 25.
Leibovich, S.J., 1978, Production of macrophage-dependant fibroblast stimulating activity (M-FSA) by murine macrophages. Effect on BALBC 3T3 fibroblasts, Exp. Cell Res. 113: 47.
Leibovich, S.J., and Ross, R., 1975, The role of the macrophage in wound repair, Am. J. Pathol, 78: 141.
Marom, Z., Weinber, K.S., and Fanburg, B.L., 1980, Effect of bleomycin on collagenolytic activity of the rat alveolar macrophage, Am. Rev. Respir. Dis. 121: 859.
Mosesson, M.W., and Amrani, D.L., 1980, The structure and bilogical activities of plasma fibronectin, Blood 56: 145.
Mosher, D.F., 1980, Fibronectin, Prog. Hemostasis Thromb. 5: 111.
Rodriguez, R.J., White, R.R., Senior, R.M., and Levine, E.A., 1977, Elastase release from human alveolar macrophages: a comparison between smokers and non-smokers, Science 198: 313.
Villiger, B., Kelley, D.G., Engleman, W., Kuhn, C., and McDonald, J.A., 1981, Human alveolar macrophage fibronectin: synthesis, secretion and ultrastructural localization in vitro. (Submitted for publication).
Wahl, L., Wahl, S.M., Mergenhagen, S.E., and Martin, G.E., 1974, Collagenase production by endotoxin activated macrophages, Proc. Nat. Acad. Sci, USA 71: 3598.
Wahl, L.M., Wahl, S.M., Mergenhagen, S.E. and Martin, G.R., 1975, Collagenase production by lymphokine activated macrophages, Science 187: 261.
Weiss, J.B., 1976, Enzymic degradation of collagen, Int. Rev. Connect. Tissue Res. 7: 102.
Werb, Z., Banda, M.J., and Jones, P.A., 1980a, Degradation of connective tissue matrices by macrophages. 1. Proteolysis of elastin, glycoproteins and collagen by proteinases isolated from macrophages, J. Exp. Med. 152: 1340.
Werb, Z., Bainton D.F., and Jones, P.A., 1980b, Degradation of connective tissue matrices by macrophages III. Morphological and biochemical studies on extracellular, pericellular and intracellular events in matrix proteolysis by macrophages in culture, J. Exp. Med 152: 1537.
Werb, Z., and Gordon S., 1975a, Secretion of a specific collagenase by stimulated macrophages, J. Exp. Med. 142: 346.
Werb, Z., and Gordon, S., 1975b, Elastase secretion by stimulated macrophages. Characterization and regulation, J. Exp. Med. 142: 361.
White, R., Habicht, G.S., Godfrey, P. Janoff, A., Barton, E., and Fox, C., 1981a, Secretion of elastase and alpha-2- macroglobulin by cultured peritoneal exudative macrophages: studies on their interction, J. Lab. Clin. Med, (in press).
White, R., Janoff, A., and Godfrey, H.P., 1980a, Secretion of alpha-2-macroglobulin by human alveolar macrophages, Lung, 158: 9.
White, R., and Kuhn, C., 1980b Effects of phagocytosis of mineral dusts on elastase secretion by alveolar and peritoneal exudative macrophages, Arch. Environ. Health 35: 106.
White, R., Lee, D., Habicht, G.S., and Janoff, A., 1981b, Secretion of alpha-1-proteinase inhibitor by cultured rat alveolar macrophages, Am. Rev. Respir. Pis, (in press).
White, R., Leon, I, and Kuhn, C., 1981c, Effect of colchicine, vinblastine, D2O and cytochalasin B on elastase secretion, protein synthesis and fine structure of mouse alveolar macrophages, J. Reticuloendoth. Soc. (in press).
White, R., Lin, H.S., and Kuhn, C., 1977, Elastase secretion by peritoneal exudative and alveolar macrophages, J. Exp. Med., 146: 802.
White, R.R., Norby, D., Janoff, A., and Dearing, R., 1980c, Partial purification and characterization of mouse peritoneal exudative macrophage elastase, Biochim. Biophys. Acta, 612: 233.
White, R., White, J., and Janoff, A., 1979, Effects of cigarette smoke on elastase secretion by murine macrophages, J. Lab. Clin. Med. 94: 489.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Kuhn, C. (1982). Macrophages and the Turnover of Connective Tissue in the Lung. In: Cumming, G., Bonsignore, G. (eds) Cellular Biology of the Lung. Ettore Majorana International Science Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3403-3_15
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3403-3_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3405-7
Online ISBN: 978-1-4613-3403-3
eBook Packages: Springer Book Archive