Isoenzymes pp 58-88 | Cite as

The Chemical Nature of Isoenzymes

  • J. Henry Wilkinson


Several different structural concepts have been proposed to explain the occurrence of enzyme heterogeneity. Most of the chemical variations observed in various non-catalytic proteins have been reported to occur in enzymes. Thus the multiple forms of lactate dehydrogenase, creatine kinase and certain other enzymes have been attributed to the combination of different types of sub-unit. The various alkaline phosphatases appear to contain different amounts of neuraminic (sialic) acid, and hence differ in their electric charges and electrophoretic mobilities. The polymorphism of certain cholinesterases seems to be due to polymerization, while conformational differences and association with different carrier proteins have been suggested to account for other groups of isoenzymes.


Creatine Kinase Lactate Dehydrogenase Sialic Acid Electrophoretic Mobility Chemical Nature 
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© J. Henry Wilkinson 1970

Authors and Affiliations

  • J. Henry Wilkinson
    • 1
  1. 1.Charing Cross Hospital Medical SchoolUniversity of LondonUK

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