Abstract
The specialized role of mitochondria in intermediary metabolism requires that only certain substrates, cofactors, and metals be accessible to their interior compartments. Of the substrates that must be capable of entering the matrix space, the most important are O2, H2O, ADP, phosphate, pyruvate, and fatty acids. At the same time, products of mitochondrial oxidations and phosphorylation must have a means of exiting from the organelle. These include CO2 and ATP. Virtually all mitochondria, irrespective of their source, have been shown to be either freely permeable or to have specific transport systems that accommodate an efficient passage of these essential metabolites across the permeability barriers separating the matrix space from the surrounding cytoplasm.
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Amoore, R. E., and Bartley, W. (1958) The permeability of isolated rat liver mitochondria to sucrose, sodium chloride and potassium chloride at 0°, Biochem. J. 69: 223.
Brierley, G. P. (1974) Passive permeability and energy-linked ion movements in isolated heart mitochondria, Ann. N.Y. Acad. Sei. 227: 398.
Brierley, G. P. (1976) Monovalent cation transport by mitochondria, in Mitochondria: Bioenergetics, Biogenesis and Membrane Structure ( L. Packer and A. Gomez-Puyou, eds.), Academic Press, New York, pp. 3–20.
Brunnengraber, H., and Lowenstein,J. M. (1973) Effect of hydroxycitrate on ethanol metabolism, FEBS Lett. 36: 130.
Chance, B. (1965) The energy-linked reaction of calcium with mitochondria, J. Biol. Chem. 240: 2729.
Chance, B., and Montai, M. (1971) Ion translocation in energy-conserving membrane systems, in Current Topics in Membranes and Transport (F. Bronner and A. Kleinzeller, eds.), Vol. 2, Academic Press, New York, pp. 99–156.
Chappell, J. B. (1968) Systems for the transport of substrates into mitochondria, Br. Med. Bull. 24: 150.
Chappell, J. B., and Crofts, A. R. (1966) Ion transport and reversible volume changes of isolated mitochondria, in Regulation of Metabolic Processes in Mitochondria ( J. M. Tager, S. Papa, E. Quagliarello and E. C. Slater, eds.) Elsevier, Amsterdam, pp. 293–316.
Chappell, J. B., McGivan, J. D., and Crompton, M. (1972) The anion transporting systems of mitochondria and their biological significance, in The Molecular Basis of Biological Transport ( J. F. Woessner, Jr. and F. Huijing, eds.), Academic Press, New York, pp. 55–81.
Fonyo, A. (1968) Phosphate carrier of rat liver mitochondria. Its role in phosphate outflow, Biochem. Biophys. Res. Commun. 32: 624.
Gamble, J. G., and Lehninger, A. L. (1973) Transport of ornithine and citrulline across the mitochondrial membrane, J. Biol. Chem. 248: 610.
Grunnet, N. (1970) Oxidation of extramitochondrial NADH by rat liver mitochondria. Possible role of acetyl-SCoA elongation enzymes, Biochem. Biophys. Res. Commun. 41: 909.
Heidt, H. W., Klingenberg, M., and Milovancev, M. (1972) Differences between the ATP/ADP ratios in the mitochondrial matrix and extramitochondrial space, Eur. J. Biochem. 30: 434.
Klingenberg, M. (1970) Metabolite transport in mitochondria. An example for intracellular membrane function, in Essays in Biochemistry (P. N. Campbell and F. Dickens, eds.), Vol. 6, Academic Press, New York, pp. 117–159.
Klingenberg, M. (1976) The adenine nucleotide transport of mitochondria, in Mitochondria: Bioenergetics, Biogenesis and Membrane Structure ( L. Packer and A. Gomez-Puyou, eds.), Academic Press, New York, pp. 127–150.
Lardy, H. A., Graven, S. N., and Estrada-O, S. (1967) Specific induction and inhibition of cation and anion transport in mitochondria, Fed. Proc. 26: 1355.
Lehninger, A. L. (1971) The transport systems of mitochondria membranes, in Biomembranes (L. A. Manson, ed.), Vol. 2., Academic Press, New York, pp. 147–164.
Lehninger, A. L., Carafoli, E., and Rossi, C. S. (1967) Energy-linked ion movements in mitochondria, Adv. Enzymol. 29: 259.
Lehninger, A. L., Brand, M. D., and Reynafarje, B. (1975) Pathways and stoichiometry of H+ and Ca++ transport coupled to mitochondrial electron transport, in Electron Transfer Chains and Oxidative Phosphorylation ( E. Quagliariello, S. Papa, F. Palmieri, E. C. Slater and N. Siliprandi, eds.) North-Holland, Amsterdam, pp. 329–334.
Meijer, A. J., and Van Dam, K. (1974) The metabolic significance of transport in mitochondria, Biochim. Biophys. Acta 346: 213.
Mitchell, P. (1970) Reversible coupling between transport and chemical reactions, in Membranes and Ion Transport (E. E. Bittar, ed.), Vol. 1, Wiley-Interscience, New York, pp. 192–256.
Palmieri, F., Quagliariello, E., and Klingenberg, M. (1970) Quantitative correlation between the distribution of anions and the pH difference across the mitochondrial membrane, Eur. J. Biochem. 17: 230.
Pressman, B. C. (1970) Energy-linked transport in mitochondria, in Membranes of Mitochondria and Chloropiasts ( E. Racker, ed.), Von Nostrand Reinhold, New York, pp. 213–250.
Stein, W. D. (1967) The Movement of Molecules Across Cell Membranes, Academic Press, New York.
Williamson, J. R. (1976) Mitochondrial metabolism and cell regulation, in Mitochondria: Bioener- getics, Biogenesis and Membrane Structure ( L. Packer and A. Gomez-Puyou, eds.), Academic Press, New York, pp. 79–108.
Williamson, J. R., Anderson, J., and Browning, E. T. (1970) Inhibition of gluconeogenesis by butyl-malonate in perfused rat liver, J. Biol. Chem. 245: 1717.
Zebe, E., Delbrück, A., and Bücher, T. (1959) Uber den Glycerin-l-P Cyclus im Flugmuskel von Locusta migratoria, Biochem. Z. 331: 254.
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© 1982 Plenum Press, New York
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Tzagoloff, A. (1982). Mitochondrial Transport Systems. In: Mitochondria. Cellular Organelles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3294-7_9
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DOI: https://doi.org/10.1007/978-1-4613-3294-7_9
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