Skip to main content
SpringerLink
Log in
Book cover

Mitochondria pp 131–156Cite as

Oxidative Phosphorylation

  • Chapter

  • 318 Accesses

Part of the book series: Cellular Organelles ((BLSC))

Abstract

Oxidative phosphorylation is the single most important function of mitochondria. As the term implies, it is the process whereby the energy released from the oxidation reactions of the electron transfer chain is used for the synthesis of ATP. Because of its central role in aerobic metabolism, biochemists have invested substantial time and effort in studies of the mechanism of oxidative phosphorylation. Although numerous solutions to this problem have been proposed, they usually had to be abandoned in light of later evidence—the regularity with which this has happened has caused the remark to be made that no worse fate could befall anyone working on oxidative phosphorylation than to solve it.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Selected Readings

  • Ball, E. (1944) Energy relationships of the oxidative enzymes, Ann. N.Y. Acad. Sci. 45: 363.

    Article  CAS  Google Scholar 

  • Boyer, P. D. (1967) 180 and related exchanges in enzymic formation and utilization of nucleoside triphosphates in Current Topics in Bioenergetics (R. Sanadi, ed.), Vol. 2, Academic Press, New York, pp. 99 - 149.

    Google Scholar 

  • Boyer, P. D. (1974) Conformational coupling in biological energy transductions, in Dynamics of Energy Transducing Membranes ( L. Ernster, R. W. Estabrook and E. C. Slater, eds.), Elsevier, Amsterdam, pp. 289 - 301.

    Google Scholar 

  • Boyer, P. D., Cross, R. L., and Momsen, W. (1973) A new concept for energy coupling in oxidative phosphorylation based on a molecular explanation of the oxygen exchange reaction, Proc. Natl Acad. Sci. U.S.A. 70: 2837.

    Article  PubMed  CAS  Google Scholar 

  • Brierley, G. P., Murer, E., and Bachmann, E. (1964) Studies on ion transport. III. The accumulation of calcium and inorganic phosphate by heart mitochondria, Arch. Biochem. Biophys. 105: 89.

    Article  PubMed  CAS  Google Scholar 

  • Chance, B., and Hollunger, G. (1960) Energy linked reduction of mitochondrial pyridine nucleotide, Nature 185: 666.

    Article  PubMed  CAS  Google Scholar 

  • Chance, B., and Williams, G. R. (1955) A simple and rapid assay of oxidative phosphorylation, Nature 175: 1120.

    Article  PubMed  CAS  Google Scholar 

  • Chance, B., and Williams, G. R. (1956) The respiratory chain and oxidative phosphorylation, Adv. Enzymol. 17: 65.

    CAS  Google Scholar 

  • Greville, G. D. (1969) A scrutiny of Mitchell’s chemiosmotic hypothesis of respiratory chain and photosynthetic phosphorylation, in Current Topics in Bioenergetics (R. Sanadi, ed.), Vol. 3, Academic Press, New York, pp. 1–78.

    Google Scholar 

  • Hansen, M., and Smith, A. (1964) Studies on the mechanism of oxidative phosphorylation VII. Preparation of a submitochondrial particle (ETPH) which is capable of fully coupled oxidative phosphorylation, Biochim. Biophys. Acta 81: 214.

    CAS  Google Scholar 

  • Hanstein, W. G. (1976) Uncoupling of oxidative phosphorylation, Biochim. Biophys. Acta 456: 129.

    PubMed  CAS  Google Scholar 

  • Jacobs, E. E. (1960) Phosphorylation coupled to electron transport initiated by substituted phen- yldiamines, Biochem. Biophys. Res. Commun. 3: 536.

    Article  PubMed  CAS  Google Scholar 

  • Lardy, H., and Ferguson, S. M. (1969) Oxidative phosphorylation in mitochondria, Annu. Rev. Biochem. 38: 991.

    Article  PubMed  CAS  Google Scholar 

  • Lardy, H. A., Johnson, D., and McMurray, W. C. (1958) Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems, Arch. Biochem. Biophys. 78: 587.

    Article  PubMed  CAS  Google Scholar 

  • Lardy, H., Reed, P., and Lin, C. H. C. (1975) Antibiotic inhibitors of mitochondrial ATP synthesis, Fed. Proc. 34: 1707.

    CAS  Google Scholar 

  • Lee, C. P., and Ernster, L. (1964) Studies of the energy transfer system of submitochondrial particles. I. Competition between oxidative phosphorylation and the energy linked nicotinamide adenine dinucleotide transhydrogenase reaction, Eur. J. Biochem. 3: 385.

    Article  Google Scholar 

  • Lee, C. P., Azzone, G. F., and Ernster, L. (1964) Evidence for energy coupling in non-phosphoryl- ating electron transport particles from beef-heart mitochondria, Nature 201: 152.

    Article  PubMed  CAS  Google Scholar 

  • Lehninger, A. L. (1964) The Mitochondrion, W. A. Benjamin Co., New York.

    Google Scholar 

  • Lehninger, A. L., Carafoli, E., and Rossi, C. S. (1967) Energy-linked ion movements in mitochondrial systems, Adv. Enzymol. 29: 259.

    PubMed  CAS  Google Scholar 

  • Löw, H., and Vallin, I. (1963) Reduction of added DPN from the cytochrome c level in submitochondrial particles, Biochem. Biophys. Res. Commun. 9: 307.

    Article  Google Scholar 

  • Mitchell, P. (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism, Nature 191: 105.

    Article  Google Scholar 

  • Mitchell, P. (1966) Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation, Glynn Research Ltd., Bodmin.

    Google Scholar 

  • Mitchell, P. (1974) A chemiosmotic molecular mechanism for proton-translocating adenosine triphosphatases, FEBS Lett. 43: 189.

    CAS  Google Scholar 

  • Mitchell, P., and Moyle, J. (1967) Respiration-driven proton translocation in rat liver mitochondria, Biochem. J. 105: 1147.

    PubMed  CAS  Google Scholar 

  • Mitchell, P., and Moyle, J. (1969) Estimation of membrane potential and pH differences across the cristae membrane of rat liver mitochondria, Eur. J. Biochem. 7: 471.

    Article  PubMed  CAS  Google Scholar 

  • Nielsen, S. O., and Lehninger, A. L. (1955) Phosphorylation coupled to the oxidation of ferrocytochrome c, J. Biol. Chem. 215: 555.

    PubMed  CAS  Google Scholar 

  • Pullman, M. E., and Schatz, G. (1967) Mitochondrial oxidations and energy coupling, Annu. Rev. Biochem. 36: 539.

    Article  PubMed  CAS  Google Scholar 

  • Racker, E. (1976) A New Look at Mechanisms in Bioenergetics, Academic Press, New York.

    Google Scholar 

  • Reynafarje, B., and Lehninger, A. L. (1978) The KVsite and HVsite stoichiometry of mitochondrial electron transport, J. Biol. Chem. 253: 6331.

    PubMed  CAS  Google Scholar 

  • Rossi, C., and Lehninger, A. L. (1964) Stoichiometry of respiratory stimulated accumulation of Ca++ and phosphate, and oxidative phosphorylation in rat liver mitochondria, J. Biol. Chem. 239: 3971.

    PubMed  CAS  Google Scholar 

  • Schatz, G., and Racker, E. (1966) Partial resolution of the enzymes catalyzing oxidative phosphorylation. VII. Oxidative phosphorylation in the diphosphopyridine-cytochrome b segment of the respiratory chain: Assay and properties in submitochondrial particles, J. Biol. Chem. 241: 1429.

    PubMed  CAS  Google Scholar 

  • Slater, E. C. (1953) Mechanism of phosphorylation in the respiratory chain, Nature 172: 59.

    Article  Google Scholar 

  • Slater, E. C. (1955) Phosphorylation coupled with the oxidation of a-ketoglutarate by heart muscle sarcosomes. 3. Experiments with ferricytochrome c as hydrogen acceptor, Biochem. J. 59: 392.

    PubMed  CAS  Google Scholar 

  • Slater, E. C. (1966) Oxidative phosphorylation, in Comprehensive Biochemistry (M. Florkin and E. M. Stotz, eds.), Vol. 14, Elsevier, Amsterdam, pp. 327–387.

    Google Scholar 

  • Slater, E. C. (1971) The coupling between energy-yielding and energy-utilizing reactions in mitochondria, Q. Rev. Biophys. 4: 35.

    Article  PubMed  CAS  Google Scholar 

  • Wadkins, C. L., and Lehninger, A. L. (1963) Role of ATP-ADP exchange reaction in oxidative phosphorylation, Fed. Proc. 22: 1092.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Columbia University, New York, New York, USA

    Alexander Tzagoloff

Authors
  1. Alexander Tzagoloff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Tzagoloff, A. (1982). Oxidative Phosphorylation. In: Mitochondria. Cellular Organelles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3294-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3294-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3296-1

  • Online ISBN: 978-1-4613-3294-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation