Abstract
Burkitt lymphoma (BL) is a malignant lymphoma of children occurring with highest frequency in certain parts of Africa and New Guinea where malaria is hyperendemic. It is found in low frequency throughout the world and in nonmalarious areas.
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References
Collected reports of cases of Burkitt’s lymphoma from countries outside the endemic areas, Int. J. Cancer 2:559–609 (1967).
Adams, A., and Lindahl, T., Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells, Proc. Natl. Acad. Sci. U.S.A. 72:1477–1481 (1975).
Adams, A., Lindahl, T., and Klein, G., Linear association between cellular DNA and EBV DNA in a human lymphoblastoid cell line, Proc. Natl Acad. Sci. U.S.A. 70:2888–2892 (1973).
Armenian, H. K, and Lillienfeld, A. M., The distribution of incubation periods of neoplastic diseases, Am. J. Epidemiol 99:92–100 (1974).
Banatvala, J. E., Best, J. M., and Waller, D. K, Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma, and nasopharyngeal carcinoma, Lancet 1:1205–1208 (1972).
Bar, R. S., Delor, C. J., Clausen, K. P., Hurtubise, P., Henle, W., and Hewetson, J. F., Fatal infectious mononucleosis in a family, N. Engl J. Med. 290:363–367 (1974).
Beard, C. W., O’Conor, G. T., Thomas, L. B., and Torloni, H., Histopathological definition of Burkitt’s tumor, Bull WHO 40:601–607 (1969).
Berry, C. G., Lymphoma syndrome in northern Nigeria, Br. Med. J. 2:668–670 (1964).
Biggar, R. J., Henle, W., Fleisher, G., Procker, J., Lennette, E. T., and Henle, G., Primary Epstein-Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection, Int. J. Cancer, 22:239–243 (1978).
Biggar, R. J., Henle, G., Bocher, J., Lennette, E. T., Fleisher, G., and Henle, W., Primary Epstein-Barr virus infections in African infants. II. Chemical and serological observations during seroconversion, Int. J. Cancer 22:244–250 (1978).
Bornkamm, G. W., Stein, H., Lennart, K, Ruggeberg, F., Bartels, H., and zur Hausen, H., Attempts to demonstrate virus-specific sequences in human tumors. IV. EB viral DNA in European Burkitt lymphoma and in immunoblastic lymphadenopathy with excessive plasmacytosis, Int. J. Cancer 17:177–181 (1976).
Britton, S., Andersson-Anvret, M., Gergely, P., Henle, W., Jondal, M., Klein, G., Sandstedt, B., and Svedmyr, E., Epstein-Barr virus immunity and tissue distribution in a fatal case of infectious mononucleosis, N. Engl J. Med. 298:89–92 (1978).
Burkitt, D. P., A sarcoma involving the jaws in African children, Br. J. Surg. 46:218–223 (1958).
Burkitt, D. P., A children’s cancer dependent on climatic factors, Nature (London) 194:232–234 (1962).
Burkitt, D., Determining the climatic limitations of a children’s cancer common in Africa, Br. Med. J. 2:1019–1023 (1962).
Burkitt, D., Burkitt’s lymphoma outside the known endemic areas of Africa and New Guinea, Int. J. Cancer 2:562–565 (1967).
Burkitt, D., Etiology of Burkitt’s lymphoma—An alternative hypothesis to a vectored virus, J. Natl Cancer Inst. 42:19–28 (1969).
Burkitt, D., and Wright, D. H, Geographical and tribal distribution of the African lymphoma in Uganda, Br. Med. J. 5487:569–573 (1966).
Burkitt, D. P., and Wright, D. H. (eds.), Burkitt’s Lymphoma , Livingstone, Edinburgh, 1970.
Byrne, E. B., Evans, A. S., Fonts, D. W., and Israel, H. L., A seroepidemiological study of Epstein-Barr virus and other antigens in sarcoidosis, Am. J. Epidemiol 97:355–363 (1973).
Carbone, P., Bernard, C. W., Bennett, J. M., Zie- gler, J. L., Cohen, M. H, and Gerber, P., National Institutes of Health clinical staff conference: Burkitt’s tumor, Ann. Intern. Med. 70:817–832 (1969).
Carvalho, R. P. S., Evans, A. S., Frost, P., Dalldorf, G., Camargo, M. F., and Jamra, M., EBV infections in Brazil. I. Occurrence in normal persons, in lymphomas and in leukemias, Int. J. Cancer 11:191–201 (1973).
Chang, R. S., Lewis, J. P., and Abildgaard, C. F., Prevalence of oropharyngeal excreters of leukocyte- transforming agents among a human population, N. Engl. J. Med. 289:1325–1329 (1973).
Churchill, A. E., Payne, L. N., and Chubb, R. C., Immunization against Marek’s disease using a live attenuated virus, Nature (London) 221:744–747 (1969).
Cook, A. R., Uganda Memories, Uganda Society, 1945.
Coope, D., Heston, L., Brandsma, J., and Miller, G., Cross neutralization of infectious mononucleosis and Burkitt lymphoma strains of Epstein-Barr virus with hyperimmune rabbit antisera, J. Immunol 123:232–238 (1979).
Dalldorf, G., Lymphomas of African children. J. Am. Med. Assoc. 181:1026–1028 (1962).
Dalldorf, G., Linsell, C. A., Barnhart, F. C, and Martyn, R., An epidemiologic approach to the lymphomas of African children and Burkitt’s sarcoma of the jaws, Perspect. Biol Med. 7:435–449 (1964).
Dambaugh, T., Nkrumah, F. K, Biggar, R. J., and Kieff, E., Epstein-Barr virus RNA in Burkitt tumor tissue, Cell 16:313–322 (1979).
Davies, J. N. P., Elmes, S., Hütt, M. S. R., Mtima- valye, L. A. R., Owor, R., and Shaper, L., Cancer in an African community, 1897–1956: An analysis of the records of Mengo Hospital, Kampala, Uganda: Part 2, Br. Med. J. 1:336–341 (1964).
Dean, A. G., Williams, E. H, Attobua, G., Omeda, J., Gadi, A., Amuti, A., and Atima, S. B., Clinical events suggesting herpes-simplex infection before onset of Burkitt’s lymphoma, Lancet 2:1225–1228 (1973).
Delius, H, and Bornkamm, G. W., Heterogeneity of Epstein-Barr virus. III. Comparison of a transforming and a nontransforming virus by partial denaturation mapping of their DNAs, J. Virol 27:81–89 (1978).
deSchryver, A., Klein, G., Henle, G., Henle, W., Cameron, H. M., Santesson, L., and Clifford, P., EB-virus associated serology in malignant disease: Antibody levels to viral capsid antigens (VCA), membrane antigens (MA) and early antigens (EA) in patients with various neoplastic conditions, Int. J. Cancer 9:353–364 (1972).
de-Thé, G., Geser, A., Day, N. E., Tubei, P. M., Williams, E. H., Beir, D. P., Smith, P. G., Dean, A. G., Bornkamm, G. W., Feorino, P., and Henle, W., Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt’s lymphoma from Ugandan prospective study, Nature (London) 274:756–761 (1978).
Einhorn, N., Henle, G., Henle, W., Klein, G., and Clifford, P., Effect of local radiotherapy on the antibody levels against EBV-induced early and capsid antigens (EA and VCA) in patients with certain malignant tumours, Int. J. Cancer 9:182 (1972).
Epstein, M. A., Achong, B. G., Barr, Y. M., Zajac, B., Henle, G., and Henle, W., Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji), J. Natl. Cancer Inst. 34:547–559 (1966).
Epstein, M. A., and Barr, Y. M., Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma, Lancet 1:252–253 (1964).
Epstein, M. A., Henle, G., Achong, B. G., and Barr, Y. M., Morphological and biological studies on a virus in cultured lymphoblasts from Burkitt’s lymphoma, J. Exp. Med. 121:761–770 (1965).
Epstein, M. A., Achong, B. G., and Barr, Y. M., Virus particles in cultured lymphoblasts from Burkitt’s lymphoma, Lancet 1:702–703 (1964).
Epstein, M. A., Hunt, R. D., and Rabin, H., Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). I. Reticuloproliferative disease in an inoculated animal, Int. J. Cancer 12:309–318 (1973).
Falk, L., Wolfe, L., Deinhardt, F., Paciga, J., Dom-bos, L., Klein, G., Henle, W., and Henle, G., Epstein-Barr virus: Transformation of non-human primate lymphocytes in vitro, Int. J. Cancer 13:353–376 (1974).
Fass, L., Herberman, R. B., and Ziegler, J., Delayed cutaneous hypersensitivity reactions to autologous extracts of Burkitt-lymphoma cells, N. Engl. J. Med. 282:776–780 (1970).
Fialkow, P. J., Klein, E., Klein, G., Clifford, P., and Singh, S., Immunoglobulin and glucose-6-phosphate dehydrogenase as markers of cellular origin in Burkitt lymphoma, J. Exp. Med. 138:89–101 (1973).
Fleckenstein, B., Daniel, M. D., and Hunt, R. D., Tumor induction with DNA of oncogenic primate herpesviruses, Nature (London) 274:57–59 (1978).
Fleisher, G., Henle, W., Henle, G., Lennette, E. T., and Biggar, R. J., Primary infection with Epstein—Barr virus in infants in the the United States: Clinical and serologic observations, J. Infect. Dis. 139:553–558 (1979).
Gerber, P., Activation of Epstein-Barr virus by 5-bro-modeoxyuridine in virus free human cells, Proc. Natl. Acad. Sci. U.S.A. 69:83–85 (1972).
Gerber, P., and Hoyer, B. H., Induction of cellular DNA synthesis in human leucocytes by Epstein-Barr virus, Nature (London) 231:46–47 (1971).
Gerber, P., Nkrumah, F. K., Pritchett, R., and Kieff, E., Comparative studies of Epstein-Barr virus strains from Ghana and the United States, Int. J. Cancer 17:71–81 (1976).
Given, D., and Kieff, E., DNA of Epstein-Barr virus. IV. Linkage map of restriction enzyme fragments of the B95–8 and W91 strains of Epstein-Barr virus, J. Virol. 28:524–542 (1978).
Glaser, R., and Rapp, F., Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lympho- blastoid cells, J. Virol. 10:288–296 (1972).
Griffin, E. R., Wright, D. H., Bell, T. M., and Ross, M. G. R., Demonstration of virus particles in biopsy material from cases of Burkitt’s tumour, Eur. J. Cancer 2:353–358 (1966).
Gunven, P., Klein, G., Clifford, P., and Singh, S., Epstein-Barr virus-associated membrane-reactive antibodies during long term survival after Burkitt’s lymphoma, Proc. Natl. Acad. Sci. U.S.A. 71:1422–1426 (1974).
Hampar, B., Derge, J. G., Martos, L. M., Tagamets, M. A., Change, S. Y., and Chakrabarty, M., Identification of a critical period during the S phase for activation of the Epstein-Barr virus by 5-iododeoxy-uridine, Nature (London) New Biol. 244:214–217 (1973).
Hampar, B., Derge, J. G., Martos, L. M., and Walker, J. L., Synthesis of Epstein-Barr virus after activation of the viral genome in a virus negative human lymphoblastoid cell (Raji) made resistant to five bromodeoxyuridine, Proc. Natl. Acad. Sci. U.S.A. 69:78–82 (1972).
Henderson, E., Robinson, J., Frank, A., and Miller, G., Epstein-Barr virus: Transformation of lymphocytes separated by size or exposed to bromodeoxyuridine and light, Virology 82:196–205 (1977).
Henle, G., and Henle, W., Immunofluorescence in cells derived from Burkitt’s lymphoma, J. Bacteriol. 91:1248–1256 (1966).
Henle, G., Henle, W., Clifford, P., Diehl, V., Ka- fuko, G. W., Kirya, B. G., Klein, G., Morrow, R. H., Munube, G. M. R., Pike, M. C., Tukei, P. M., and Ziegler, J. L., Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups, J. Natl. Cancer Inst. 43:1147–1157 (1969).
Henle, W., Diehl, V., Kohn, G., zur Hausen, H., and Henle, G., Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells, Science 157:1064–1065 (1967).
Henle, W., Henle, G., Gunven, P., Klein, G., Clifford, P., and Singh, S., Patterns of antibodies to Epstein-Barr virus-induced early antigens in Burkitt’s lymphoma: Comparison of dying patients with long term survivors, J. Natl. Cancer Inst. 50:1163–1173 (1973).
Henle, W., Henle, G., Zajac, B. A., Pearson, G., Waubke, R., and Scriba, M., Differential reactivity of human serums with early antigens induced by Epstein-Barr virus, Science 169:188–190 (1970).
Hilgers, J., Dean, A. G., andde-The, G. B., Elevated immunofluorescence titers to several herpes viruses in Burkitt’s lymphoma patients: Are high titers unique? J. Natl. Cancer Inst. 54:49–51 (1975).
Hinuma, Y., Konn, M., Yamaguchi, J., Wudarski, D. J., Blakeslee, J. R., and Grace, J. T., Jr., Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line, J. Virol. 1:1045–1051 (1967).
Hirshaut, Y., Cohen, M. H., and Stevens, D. A., Epstein-Barr virus antibodies in American and African Burkitt’s lymphoma, Lancet 2:114–116 (1973).
Jondal, M., and Klein, G., Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes, J. Exp. Med. 138:1365–1378 (1973).
Jondal, M., Svedmyr, E., and Klein, E., Killer T cells in a Burkitt’s lymphoma biopsy, Nature (London) 255:405–407 (1975).
Judson, S. C., Henle, W., and Henle, G., A cluster of Epstein-Barr virus-associated American Burkitt’s lymphoma, N. Engl. J. Med. 297:464–468 (1977).
Kafuko, G. W., and Burkitt, D. P., Burkitt’s lymphoma and malaria, Int. J. Cancer 6:1–9 (1970).
Kafuko, G. W., Henderson, B. E., Kirya, B. G., Mu-nube, G. M. R., Tukei, P. M., Day, N. E., Henle, G., Henle, W., Morrow, R. H., Pike, M. C., Smith, P. G., and Williams, E. H., Epstein-Barr virus antibody levels in children from the West Nile District of Uganda, Lancet 1:706 (1972).
Kaschka-dierich, C., Adams, A., Lindahl, T., Born-kamm, G., Bjursell, G., Klein, G., Giovanella, B., and Singh, S., Intracellular forms of Epstein-Barr virus DNA in human tumor cells in vivo, Nature (London) 260:302–306 (1976).
Kinter, C. R., and Sugden, B., The structure of the termini of the DNA of Epstein-Barr virus, Cell 17:661–672 (1979).
Klein, G., Clifford, P., Klein, E., and Stjernsward, J., Search for tumor specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction, Proc. Natl. Acad. Sci. U.S.A. 55:1628–1635 (1966).
Klein, G., Lindahl, T., Jondal, M., Leibold, W., Menezes, J., Nilsson, K, and Sundstrom, C., Continuous lymphoid cell lines with B-cell characteristics that lack the Epstein-Barr virus genome, derived from three human lymphomas, Proc. Natl. Acad. Sci. U.S.A. 71:3283–3286 (1974).
Kufe, D., Hehlmann, R., and Spiegelman, S., RNA related to that of a murine leukemia virus in Burkitt’s tumors and nasopharyngeal carcinoma, Proc. Natl. Acad. Sci. U.S.A. 70:5–9 (1973).
Levine, P. H., Ablashi, D. V., and Berard, C. W., Elevated antibody titers to Epstein-Barr virus in Hodgkin’s disease, Cancer 27:416–421 (1971).
Levine, P. H., O’Conor, G. T., and Berard, C. W., Antibodies to Epstein-Barr virus (EBV) in American patients with Burkitt’s lymphoma, Cancer 30:610–615 (1972).
Levy, J. A., and Henle, G., Indirect immunofluorescence tests with sera from African children and cultured Burkitt lymphoma cells, J. Bacteriol, 92:275–276 (1966).
Lindahl, T., Klein, G., Reedman, B. M., Johanson, B., and Singh, S., Relationship between Epstein-Barr virus (EBV) DNA and the EBV-determined nuclear antigen (EBNA) in Burkitt lymphoma biopsies and other lymphoproliferative malignancies, Int. J. Cancer 13:764–772 (1974).
Luka, J., Lindahl, T., and Klein, G., Purification of the Epstein-Barr virus-determined nuclear antigen from Epstein-Barr virus-transformed human lymphoid cell lines, J. Virol. 27:604–611 (1978).
Miller, G., Oncogenicity of Epstein-Barr virus, J. Infect. Dis. 130:187–205 (1974).
Miller, G., and Coope, D., Epstein-Barr viral nuclear antigen (EBNA) in tumor cell imprints of experimental lymphoma of marmosets, Trans. Assoc. Am. Physicians 87:205–218 (1974).
Miller, G., and Lipman, M., Comparison of the yield of infectious virus from clones of human and simian lymphoblastoid lines transformed by Epstein-Barr virus, J. Exp. Med. 138:1398–1412 (1973).
Miller, G., Lisco, H., Kohn, H. I., and Stitt, D., Establishment of cell lines from normal adult human blood leukocytes by exposure to Epstein-Barr virus and neutralization by human sera with Epstein-Barr virus antibody, Proc. Soc. Exp. Biol. Med. 137:1459–1465 (1971).
Miller, G., Niederman, J. C., and Andrews, L., Prolonged oropharyngeal excretion of EB virus following infectious mononucleosis, N. Engl. J. Med. 288:229–232 (1973).
Miller, G., Robinson, J., Heston, L., and Lipman, M., Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference, Proc. Natl. Acad. Sci. U.S.A. 71:4006–4010 (1974).
Miller, G., Shope, T., Coope, D., Waters, L., Pa- gano, J., Bornkamm, G. W., and Henle, W., Lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus: Tumor incidence, histologic spectrum, antibody responses, demonstration of viral DNA, and characterization of viruses, J. Exp. Med. 145:948–967 (1977).
Miller, G., Shope, T., Lisco, H., Stitt, D., and Lip- man, M., Epstein-Barr virus: Transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes, Proc. Natl. Acad. Sci. U.S.A. 69:383–387 (1972).
Miller, M. H., Stitt, D., and Miller, G., Epstein-Barr viral antigen in single cell clones of two human leukocytic lines, J. Virol. 6:699–701 (1970).
Morrow, R. H., Pike, M. C., and Smith, P. G. Epidemiology of Burkitt’s lymphoma in the Mengo Districts, Uganda, 1957–1968, Presented at the annual meeting of the American Epidemiological Society, April 5–6, 1974.
Morrow, R. H., Pike, M. C., Smith, P. G., Ziegler, J. L., and Kisuule, A., Burkitt’s lymphoma: A time-space cluster of cases in Bwamba County of Uganda, Br. Med. J. 2:491–492 (1971).
Nadkarni, J. S., Nadkarni, J. J., Klein, G., Henle, W., Henle, G., and Clifford, P., EB viral antigens in Burkitt tumor biopsies and early cultures, Int. J. Cancer 6:10–17 (1970).
Niederman, J., Miller, G., Pearson, H., and Pagano, J., Patterns of excretion of Epstein-Barr virus in saliva and other oropharyngeal sites during infectious mononucleosis, N. Engl. J. Med. 294:1355–1359 (1976).
Nonoyama, M., Huang, C. H., Pagano, J. S., Klein, G., and Singh, S., DNA of Epstein-Barr virus detected in tissue of Burkitt’s lymphoma and nasopharyngeal carcinoma, Proc. Natl. Acad. Sci. U.S.A. 70:3265–3268, (1973).
Nonoyama, M., and Pagano, J. S., Separation of Epstein-Barr virus DNA from large chromosomal DNA in non-virus producing cells, Nature (London) New Biol. 238:169 (1972).
O’Conor, G. T., Malignant lymphoma in African children. II. A pathological entity, Cancer 14:270–283 (1961).
O’Conor, G. T., Persistent immunologic stimulation as a factor in oncogenesis, with special reference to Burkitt’s tumor, Am. J. Med. 48:279–285 (1970).
Old, L. J., Boyse, E. A., Oettgen, H. F., deHarven, E., Geering, G., Williamson, B., and Clifford, P., Precipitating antibody in human serum to an antigen present in cultured Burkitt’s lymphoma cells, Proc. Natl. Acad. Sci. U.S.A. 56:1669–1704 (1966).
Pearson, G. R., and Qualtiere, L. T., Papain solubilization of the Epstein-Barr virus-induced membrane antigen, J. Virol. 28:344–351 (1978).
Pike, M. C., Morrow, R. H., Kisuule, A., and Ma- figiri, J., Burkitt’s lymphoma and sickle cell trait, Br. J. Prev. Soc. Med. 24:39–41 (1970).
Pike, M. C., Williams, E. H., and Wright, B., Burkitt’s tumour in the West Nile District of Uganda 1961–5, Br. Med. J. 2:395–399 (1967).
Pope, J. H., Horne, M. K, and Scott, W., Identification of the filtrable leukocyte-transforming factor of QIMR-WIL cells as herpes-like virus, Int. J. Cancer 4:255–260 (1969).
Powell, A. L. T., King, W., and, Kieff, E., Epstein-Barr virus-specific RNA. III. Mapping of DNA encoding viral RNA in restringent infection, J. Virol. 29:261–274 (1979).
Pulvertaft, R. J. V., Cytology of Burkitt’s tumor (African lymphoma), Lancet 1:238–240 (1964).
Purtilo, D. T., De Florio, D., Hutt, L. M., Bhawan, J., Yang, J. P. S., Otto, R., and Edwards, W., Variable phenotypic expression of an X-linked recessive lymphoproliferative syndrome, N. Engl. J. Med. 297:1077–1081 (1977).
Reedman, B. M., and Klein, G., Cellular localization of an Epstein-Barr virus (EBV)-associated comple- ment-fixing antigen in producer and non-producer lymphoblastoid cell lines, Int. J. Cancer 11:499–520 (1973).
Reedman, B. M., Klein, G., Pope, J. H., Walters, M. L., Hilgers, J., Singh, S., and Johansson, B., Epstein-Barr virus-associated complement-fixing and nuclear antigens in Burkitt lymphoma biopsies, Int. J. Cancer 13:755–763 (1974).
Robinson, J., and Miller, G., Assay for Epstein-Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood, J. Virol. 15:1065–1072 (1975).
Rymo, L., and Forsblom, S., Cleavage of Epstein-Barr virus DNA by restriction endonucleases EcoRI, Hind III, and Bam I, Nucleic Acids Res. 5:1387–1402 (1978).
Schmitz, H., and Scherer, M., IgM antibodies to Epstein-Barr virus in infectious mononucleosis, Arch. Gesamte Virusforsch. 37:332–339 (1972).
Schulte-Holthausen, H., and zur Hausen, H., Partial purification of the Epstein-Barr virus and some properties of its DNA, Virology 40:776–779 (1970).
Shope, T., Dechairo, D., and Miller, G., Malignant lymphoma in cotton-top marmosets following inoculation of Epstein-Barr virus, Proc. Natl. Acad. Sci. U.S.A. 70:2487–2491 (1973).
Stjernsward, J., Clifford, P., and Svedmyr, E., General and tumor destructive cellular immunological reactivity, in: Burkitt’s Lymphoma (D. P. Burkitt and D. H. Wright, eds.), pp. 164–171, Livingstone, Edinburgh, 1970.
Strauch, B., Siegel, N., Andrews, L., and Miller, G., Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressive drugs, Lancet 1:234–237 (1974).
Sugden, B., Comparison of Epstein-Barr viral DNA’s in Burkitt lymphoma biopsy cells and in cells clonally transformed in vitro, Proc. Natl. Acad. Sci. U.S.A. 74:4651–4655 (1977).
Sugden, B., and Mark, W., Clonal transformation of adult human leukocytes by Epstein-Barr virus, J. Virol 23:503–508 (1978).
Svedmyr, E., and Jondal, M., Cytotoxic effector cells specific for B cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis, Proc. Natl Acad. Sci. U.S.A. 72:1622–1626 (1975).
Vanier, T. M., and Pike, M. C., Leukemia incidence in tropical Africa, Lancet 1:512–513 (1967).
Walters, M. K., and Pope, J. H., Studies of the EB virus-related antigens of human leukocyte cell lines, Int. J. Cancer 8:32–40 (1971).
Werner, J., Henle, G., Pinto, C. A., Haff, R. F., and Henle, W., Establishment of continuous lymphoblast cultures from leukocytes of gibbons (Hylobates lar), Int. J. Cancer 10:557–567 (1972).
Williams, E. H., Day, N. E., and Geser, A. G., Seasonal variation in onset of Burkitt’s lymphoma in the West Nile District of Uganda, Lancet 2:19–22 (1974).
Witkey, I. S., Malignant lymphoma in Papua, New Guinea: Epidemiologic aspects, J. Natl Cancer Inst. 50:1703–1711 (1973).
Wolf, H., Werner, J., and zur Hausen, H., EBV DNA in nonlymphoid cells of nasopharyngeal carcinomas and in a malignant lymphoma obtained after inoculation of EBV into cottontop marmosets, Cold Spring Harbor Symp. Quant. Biol 39:791–796
Wolf, H, zur Hausen, H, and Becker, V., EB viral genomes in epithelial nasopharyngeal carcinoma cells, Nature (London) New Biol 244:245–247 (1973).
Yamamoto, N., and Hinuma, Y., Clonal transformation of human leukocytes by Epstein-Barr virus in soft agar, Int. J. Cancer 17:191–196 (1976).
Zech, L., Haglund, A., Nilsson, K., and Klein, G., Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas, Int. J. Cancer 17:47–56 (1976).
Ziegler, J. L., Andersson, M., Klein, G., and Henle, W., Detection of Epstein-Barr virus DNA in American Burkitt’s lymphoma, Int. J. Cancer 17:701–706 (1976).
Ziegler, J. L., Morrow, R. H, Jr., Templeton, A. C., Templeton, C., Bluming, A. Z., Fass, L., and Kyalwazi, S. K, Clinical features and treatment of childhood malignant lymphoma in Uganda, Int. J. Cancer 5:415–425 (1970).
zur Hausen, H, and Schulte-Holthausen, H, Presence of EB virus nucleic acid homology in a “virus- free” line of Burkitt tumor cells, Nature (London) 227:245–248 (1970).
zur Hausen, H, Schulte-Holthausen, H, Klein, G., Henle, W., Henle, G., Clifford, P., and Santesson, L., EB-virus DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx, Nature (London) 228:1056–1057 (1970).
Suggested Reading
Epstein, M. A., and Achong, B., (eds), The Epstein-Barr Virus, Springer-Verlag Berlin, Heidelberg, New York, (1979)
Miller, G., Biology of EB virus, in: Viral Oncology (G. Klein, ed.), pp. 713–738, Raven Press, New York, (1979).
De-Thé, G., The epidemiology of Burkitt lymphoma, Epidemiol Rev. 1:32–54, (1979).
Henle, W., Henle, G., and Lennette, E. T., The Epstein-Barr virus. Sci. Am. 241:48–59 (1979)
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Miller, G. (1982). Burkitt Lymphoma. In: Evans, A.S. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3237-4_24
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